Cover article – A Gata4 nuclear GFP transcriptional reporter to study endoderm and cardiac development in the mouse

The GATA zinc-finger transcription factor GATA4 is important for endoderm and cardiac development. Anna-Katerina Hadjantonakis and colleagues have generated a novel nuclear localized fluorescent reporter that labels nuclei of Gata4 expressing cells and is suitable for time-lapse imaging and single cell analyses in the mouse.

Featured article  – Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5

PEPCK1 is ubiquitinated by E3 ubiquitin ligase UBR5, which was thought to be facilitated by the acetylation of Lys70, Lys71 and Lys594 in PEPCK1. By assaying UBR5 HECT domain truncation variants Zongchao Jia and team showed this is not the case, the N-terminal lobe of the UBR5 HECT domain is largely responsible for interacting with PEPCK1. They then identified PEPCK1 ubiquitination sites.

First person interviews

 
Have you seen our interviews with the early-career first authors of our papers? Recently, we caught up with first authors De-Li Xu, Claire Simon and Andrea Cappa.

Why should you publish your next paper in BiO?

Biology Open has strong credentials and publishing with us is easy and fast. BiO aims to provide rapid publication for scientifically sound observations and valid conclusions in developmental, cell, experimental and translational biology. Submit your paper here; you’ll be in good company.

Recent experimental biology highlights in BiO – Mark I. McCormick and colleagues show that fish exhibit water flow-induced changes in their fast-start escape performance, likely due to an in situ training effect and/or selection for faster performance phenotypes in areas with high flow speed.

Transfer to Biology Open

If your submission to one of our other journals, Development, Journal of Cell Science, Journal of Experimental Biology or Disease Models & Mechanism, is unsuccessful, did you know you can transfer your paper and any reviews directly to Biology Open? The majority of papers transferred with reviews are accepted for publication. Find out how here.

preLights - Disrupting transcriptional feedback yields an escape-resistant antiviral

Pavithran Ravindran discusses the preprint from Leor Weinberger and colleagues, who created a new anti-viral drug modality that uses a 28 base pair piece of DNA to have a virus reduce its own progression without any sign of resistance.