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  Open access

Table of Contents

February 15, 2017; 6 (2)

RESEARCH ARTICLES

  • Open Access
    Innovative approaches to establish and characterize primary cultures: an ex vivo 3D system and the zebrafish model
    Chiara Liverani, Federico La Manna, Arwin Groenewoud, Laura Mercatali, Gabri Van Der Pluijm, Federica Pieri, Davide Cavaliere, Alessandro De Vita, Chiara Spadazzi, Giacomo Miserocchi, Alberto Bongiovanni, Federica Recine, Nada Riva, Dino Amadori, Ennio Tasciotti, Ewa Snaar-Jagalska, Toni Ibrahim
    Biology Open 2017 6: 133-140; doi: 10.1242/bio.022483

    Summary: Patient-derived primary cells maintain their original phenotype when cultured on 3D scaffolds, and their in vivo behavior can be effectively studied with innovative zebrafish models.

  • Open Access
    Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson's disease
    Susann Lehmann, Samantha H. Y. Loh, L. Miguel Martins
    Biology Open 2017 6: 141-147; doi: 10.1242/bio.022186

    Summary: Dietary supplementation with an NAD+ salvage metabolite or decreasing Parp activity suppress mitochondrial dysfunction and is neuroprotective in a PINK1 model of Parkinson's disease.

  • Open Access
    Meningeal retinoic acid contributes to neocortical lamination and radial migration during mouse brain development
    Carole Haushalter, Brigitte Schuhbaur, Pascal Dollé, Muriel Rhinn
    Biology Open 2017 6: 148-160; doi: 10.1242/bio.021063

    Summary: Involvement of the signalling molecule retinoic acid in neurogenesis of the developing cerebral cortex is shown through targeted deletion of its synthesizing enzyme.

  • Open Access
    Protein kinase C is involved with upstream signaling of methyl farnesoate for photoperiod-dependent sex determination in the water flea Daphnia pulex
    Kenji Toyota, Tomomi Sato, Norihisa Tatarazako, Taisen Iguchi
    Biology Open 2017 6: 161-164; doi: 10.1242/bio.021857

    Summary: This study is the first experimental evidence that PKC is involved in the male sex determination process associated with methyl farnesoate signaling in daphnid species.

  • Open Access
    The Crumbs_C isoform of Drosophila shows tissue- and stage-specific expression and prevents light-dependent retinal degeneration
    Stephanie Spannl, Alexandra Kumichel, Sarita Hebbar, Katja Kapp, Marcos Gonzalez-Gaitan, Sylke Winkler, Rosana Blawid, Gregor Jessberger, Elisabeth Knust
    Biology Open 2017 6: 165-175; doi: 10.1242/bio.020040

    Summary: Loss of Crb_C, one protein isoform encoded by Drosophila crumbs, results in light-dependent retinal degeneration, but does not affect any of the other crumbs-specific functions.

  • Open Access
    A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells
    Taylor E. Miller, Julian Gomez-Cambronero
    Biology Open 2017 6: 176-186; doi: 10.1242/bio.021261

    Summary: Cell signaling enzyme phospholipase D2 (PLD2) and its reaction product, phospholipid phosphatidic acid (PA), are involved in mediating PARN-induced eukaryotic mRNA decay.

  • Open Access
    A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development
    V. Sivakamasundari, Petra Kraus, Wenjie Sun, Xiaoming Hu, Siew Lan Lim, Shyam Prabhakar, Thomas Lufkin
    Biology Open 2017 6: 187-199; doi: 10.1242/bio.023218

    Summary: In this study, we show the essential molecular roles of Pax1/Pax9 in early IVD development and their connection with other chrondrogenic players – Sox trio, BMP and TGF B pathways.

  • Open Access
    A polycystin-type transient receptor potential (Trp) channel that is activated by ATP
    David Traynor, Robert R. Kay
    Biology Open 2017 6: 200-209; doi: 10.1242/bio.020685

    Summary: We show that a Trp channel related to the mammalian polycystin channel, rather than a P2X receptor, is responsible for the purinergic stimulation of cytosolic calcium levels in Dictyostelium cells.

  • Open Access
    Diet quality determines lipase gene expression and lipase/esterase activity in Daphnia pulex
    Apostolos-Manuel Koussoroplis, Anke Schwarzenberger, Alexander Wacker
    Biology Open 2017 6: 210-216; doi: 10.1242/bio.022046

    Summary: We show for the first time that the waterflea Daphnia pulex has the ability to finely tune its lipolytic machinery to changes in the nutritional quality of its diet.

  • Open Access
    Lipid droplet dynamics during Schizosaccharomyces pombe sporulation and their role in spore survival
    Hui-Ju Yang, Hiroko Osakada, Tomoko Kojidani, Tokuko Haraguchi, Yasushi Hiraoka
    Biology Open 2017 6: 217-222; doi: 10.1242/bio.022384

    Summary: Lipid droplets of yeast mother cells are shown to redistribute to their nascent spores by live-cell imaging analysis, suggesting that the lipid droplets are important for yeast spore survival.

  • Open Access
    Analysis of the Fgfr2C342Y mouse model shows condensation defects due to misregulation of Sox9 expression in prechondrocytic mesenchyme
    Emma Peskett, Samin Kumar, William Baird, Janhvi Jaiswal, Ming Li, Priyanca Patel, Jonathan A. Britto, Erwin Pauws
    Biology Open 2017 6: 223-231; doi: 10.1242/bio.022178

    Summary: Mutation of FGFR2 causes a misregulation of Sox9, leading to disrupted mesenchymal condensation, and thus skeletal and craniofacial birth defects in mice, with implications for human Crouzon syndrome.

  • Open Access
    Dynamic analysis of the mesenchymal-epithelial transition of blood-brain barrier forming glia in Drosophila
    Tina Schwabe, Xiaoling Li, Ulrike Gaul
    Biology Open 2017 6: 232-243; doi: 10.1242/bio.020669

    Summary: This study examines the major steps and underlying mechanisms of mesenchymal-epithelial transition of the blood-brain-barrier forming glia in Drosophila, including the role of basal lamina, septate junctions and of trimeric G protein signaling.

  • Open Access
    Establishment and maintenance of sexual preferences that cause a reproductive isolation between medaka strains in close association
    Mayuka Ikawa, Emi Ohya, Hiroka Shimada, Makiko Kamijo, Shoji Fukamachi
    Biology Open 2017 6: 244-251; doi: 10.1242/bio.022285

    Summary: Two laboratory strains of medaka assortatively mate in complete sympatry, and their sexual preferences are gradually developed during growth and firmly maintained after sexual maturation.

  • Open Access
    MiR-142 modulates human pancreatic cancer proliferation and invasion by targeting hypoxia-inducible factor 1 (HIF-1α) in the tumor microenvironments
    Yebin Lu, Niandong Ji, Wei Wei, Weijia Sun, Xuejun Gong, Xitao Wang
    Biology Open 2017 6: 252-259; doi: 10.1242/bio.021774

    Summary: Our findings provide insights to the functional mechanism of miR-142, suggesting that the miR-142/HIF-1α axis may interfere with the proliferative and invasive property of pancreatic cancer cells.

  • Open Access
    Trehalose 6-phosphate signal is closely related to sorbitol in apple (Malus domestica Borkh. cv. Gala)
    Wen Zhang, John E. Lunn, Regina Feil, Yufei Wang, Jingjing Zhao, Hongxia Tao, Yanping Guo, Zhengyang Zhao
    Biology Open 2017 6: 260-268; doi: 10.1242/bio.022301

    Summary: Metabolite analysis of the Tre6P pathway in apple fruit, Malus domestica, reveals that Tre6P levels were highly and positively correlated with sorbitol content, but not with sucrose content.

  • Open Access
    The effect of foot posture on capacity to apply free moments to the ground: implications for fighting performance in great apes
    David R. Carrier, Christopher Cunningham
    Biology Open 2017 6: 269-277; doi: 10.1242/bio.022640

    Summary: We tested the capacity of the heel-down foot posture of great apes to apply free moments to the ground because this could influence performance when fighting from a bipedal stance.

  • Open Access
    Identification of SSR markers closely linked to the yellow seed coat color gene in heading Chinese cabbage (Brassica rapa L. ssp. pekinensis)
    Yanjing Ren, Junqing Wu, Jing Zhao, Lingyu Hao, Lugang Zhang
    Biology Open 2017 6: 278-282; doi: 10.1242/bio.021592

    Summary: Genetic mapping of the yellow seed coat gene Brsc-ye to a 40.2 kb region of the Chinese cabbage (Brassica rapa ssp. pekinensis) genome will allow marker-assisted selection and breeding of yellow-seeded lines.

  • Open Access
    Vasotocin receptor blockade disrupts maternal care of offspring in a viviparous snake, Sistrurus miliarius
    Craig M. Lind, Nikolette K. Birky, Anita M. Porth, Terence M. Farrell
    Biology Open 2017 6: 283-289; doi: 10.1242/bio.022616

    Summary: In a squamate reptile, post-birth maternal effort is related to maternal energetic status, and vasotocin receptors may play a role in mediating maternal care.

  • Open Access
    Oocyte shuttle, a recombinant protein transporting donor DNA into the Xenopus oocyte in situ
    Duri Rungger, Lisbeth Muster, Oleg Georgiev, Elisabeth Rungger-Brändle
    Biology Open 2017 6: 290-295; doi: 10.1242/bio.022376

    Summary: A newly developed oocyte shuttle protein, binding donor DNA and carrying it from the bloodstream to the oocyte nucleus within the ovary, should greatly facilitate production of transgenic Xenopus embryos.

METHODS & TECHNIQUES

  • Open Access
    A genetically encoded biosensor for visualising hypoxia responses in vivo
    Tvisha Misra, Martin Baccino-Calace, Felix Meyenhofer, David Rodriguez-Crespo, Hatice Akarsu, Ricardo Armenta-Calderón, Thomas A. Gorr, Christian Frei, Rafael Cantera, Boris Egger, Stefan Luschnig
    Biology Open 2017 6: 296-304; doi: 10.1242/bio.018226

    Summary: This study describes a biosensor for visualising the hypoxic state of cells in vivo. They demonstrate that the Drosophila larval brain contains distinct hypoxic microenvironments that correlate with local airway supply.

CORRESPONDENCE

  • Open Access
    On the importance of understanding physiology when estimating energetics in cetaceans
    Lars P. Folkow, Arnoldus Schytte Blix
    Biology Open 2017 6: 306 doi: 10.1242/bio.023929

    Summary: Fahlman and associates (2016) have emphasized the importance of proper physiological insight when modelling energy expenditure in large cetaceans. Here we argue that they have themselves failed in this endeavour.

  • Open Access
    Response to ‘On the importance of understanding physiology when estimating energetics in cetaceans’
    A. Fahlman, J. van der Hoop, M. J. Moore, G. Levine, J. Rocho-Levine, M. Brodsky
    Biology Open 2017 6: 307-308; doi: 10.1242/bio.023143

    Summary: Our paper highlights how temporal changes in tidal volume and the oxygen exchange ratio significantly affect the accuracy of models that use only breathing frequency to estimate metabolic rate.

CORRECTION

  • Open Access
    CORRECTION: Innovative approaches to establish and characterize primary cultures: an ex vivo 3D system and the zebrafish model
    Chiara Liverani, Federico La Manna, Arwin Groenewoud, Laura Mercatali, Gabri Van Der Pluijm, Federica Pieri, Davide Cavaliere, Alessandro De Vita, Chiara Spadazzi, Giacomo Miserocchi, Alberto Bongiovanni, Federica Recine, Nada Riva, Dino Amadori, Ennio Tasciotti, Ewa Snaar-Jagalska, Toni Ibrahim
    Biology Open 2017 6: 309 doi: 10.1242/bio.023911
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