Table of Contents
- Parecoxib inhibits glioblastoma cell proliferation, migration and invasion by upregulating miRNA-29c
Summary: The study indicated that parecoxib may be a potential therapeutic approach to treat GBM by up-regulating miRNA-29c and subsequently inhibiting proliferation, migration and invasion of GBM.
- Constitutively active Notch1 converts cranial neural crest-derived frontonasal mesenchyme to perivascular cells in vivo
Summary: Sustained Notch1 activation is sufficient to drive cranial neural crest-derived frontonasal mesenchyme to adopt a perivascular (mural) cell fate in developing chick embryos.
- Enhanced store-operated Ca2+ influx and ORAI1 expression in ventricular fibroblasts from human failing heart
Summary: The excessive collagen secretory phenotype found in failing human hearts is associated with ventricular fibroblast remodeling, caused by an elevated influx of intracellular calcium via SOC channels.
- The correlation between the length of repetitive domain and mechanical properties of the recombinant flagelliform spidroin
Summary: A study of the relationship between the structure and property of synthetic spider silk-like fibers, which aims to aid with the designing of functional artificial fibers.
- Behavioral evidence for a magnetic sense in the oriental armyworm, Mythimna separata
Summary: Responses to changes in the intensity and direction of magnetic fields in the armyworm moth (Mythimna separata) indicate a reliance on a magnetic compass for flight orientation.
- Disruption of pdgfra alters endocardial and myocardial fusion during zebrafish cardiac assembly
Summary: The molecular mechanisms regulating cardiac fusion are not well understood. Here, we show that platelet-derived growth factor receptor alpha is essential for normal endocardial and myocardial fusion during zebrafish development.
- Smad4 regulates growth plate matrix production and chondrocyte polarity
Summary: Smad4 is a key regulator of extracellular matrix production and chondrocyte proliferation, shape and orientation in the growth plate. Smad4 dysregulation results in skeletal dysplasias, such as Myhre syndrome.
- Preference for and learning of amino acids in larval Drosophila
Summary: Drosophila larvae show positive preference but for a few individual amino acids. The preference partially changes depending on larval stage and deprivation. In learning experiments, all 20 tested amino acids were equally rewarding.
- Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells
Summary: A mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells, with implications for the maintenance of vascular integrity and vascular disease research.
- A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies
Summary: PLK4 and STIL/Ana2 proteins interact to promote centriole duplication. We show that these proteins may homo-multimerise in multiple ways, and that their interaction is likely complex and may differ between species.
METHODS & TECHNIQUES
- Quantitative microscopy uncovers ploidy changes during mitosis in live Drosophila embryos and their effect on nuclear size
Summary: A new 3D time-lapse microscopy image analysis pipeline consisting of nuclear segmentation, tracking, annotation and quantification revealed karyotype changes in Drosophila embryos.
- Simplified 3D protocol capable of generating early cortical neuroepithelium
Summary: We present a simplified method to generate early neuroepithelium of the cerebellar cortex in a 3D culture using defined medium and minimal addition of growth factors.