The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in regulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level REV-ERBα modulates the expression of FGF21 via the liver specific hepatic nuclear factor 6 (HNF6). We conclude, that REV-ERBα regulates metabolism and reproduction at least in part via regulation of Fgf21.
- Received August 29, 2016.
- Accepted November 7, 2016.
- © 2016. Published by The Company of Biologists Ltd
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