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Accepted Manuscript
Research Article
Ectopic otoconial formation in the lagena of the pigeon inner ear
E. Pascal Malkemper, Matthew J. Mason, Daniel Kagerbauer, Simon Nimpf, David A. Keays
Biology Open 2018 : bio.034462 doi: 10.1242/bio.034462 Published 11 July 2018
E. Pascal Malkemper
Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus Vienna Biocenter 1, Vienna 1030, Austria
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  • For correspondence: keays@imp.ac.aterich.malkemper@imp.ac.at
Matthew J. Mason
University of Cambridge, Department of Physiology, Development & Neuroscience, Downing Street, Cambridge, CB2 3EG, UK
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  • ORCID record for Matthew J. Mason
Daniel Kagerbauer
TU Wien, Atominstitut, Stadionallee 2, 1020 Vienna, Austria
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Simon Nimpf
Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus Vienna Biocenter 1, Vienna 1030, Austria
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David A. Keays
Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Campus Vienna Biocenter 1, Vienna 1030, Austria
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  • ORCID record for David A. Keays
  • For correspondence: keays@imp.ac.aterich.malkemper@imp.ac.at
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Abstract

The vertebrate inner ear contains vestibular receptors that contain dense crystals of calcium carbonate, the otoconia. The production and maintenance of otoconia is a delicate process, the perturbation of which can lead to severe vestibular dysfunction in humans. The details of these processes are not well understood. Here, we report the discovery of a new otoconial mass in the lagena of adult pigeons that was present in more than 70% of birds. Based on histological, tomographic and elemental analyses, we conclude that the structure likely represents an ectopically-formed otoconial assembly. Given its frequent natural occurrence, we suggest that the pigeon lagena is a valuable model system for investigating misregulated otoconial formation.

  • Received March 26, 2018.
  • Accepted June 20, 2018.
  • © 2018. Published by The Company of Biologists Ltd
http://creativecommons.org/licenses/by/3.0

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Keywords

  • Inner ear
  • Otolith
  • Vestibular organs
  • Avian lagena
  • Tegmentum vasculosum
  • Dark cells
  • Magnetoreception

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Accepted Manuscript
Research Article
Ectopic otoconial formation in the lagena of the pigeon inner ear
E. Pascal Malkemper, Matthew J. Mason, Daniel Kagerbauer, Simon Nimpf, David A. Keays
Biology Open 2018 : bio.034462 doi: 10.1242/bio.034462 Published 11 July 2018
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Accepted Manuscript
Research Article
Ectopic otoconial formation in the lagena of the pigeon inner ear
E. Pascal Malkemper, Matthew J. Mason, Daniel Kagerbauer, Simon Nimpf, David A. Keays
Biology Open 2018 : bio.034462 doi: 10.1242/bio.034462 Published 11 July 2018

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