Jordan is the César Milstein Chair of Molecular Cancer Biology in the Sir William Dunn School of Pathology at the University of Oxford. He did his PhD with David Glover at Imperial College, London and was then a Lucille Markey visiting post-doctoral fellow with Bruce Alberts in the Department of Biochemistry and Biophysics at UCSF. He moved back to the UK in 1994 to start up his own group as a Wellcome Senior Research Fellow at what is now known as the Gurdon Institute in Cambridge. He and his group moved to Oxford in 2010. His group is interested in centrosomes and the cell cycle, primarily using Drosophila as a model system, but also venturing into human cells when they need to. They are currently focusing on trying to understand the basic mechanisms of centrosome duplication and on how centrosome amplification is linked to cancer. He is currently President of the British Society for Cell Biology.
Areas of expertise: Centrosomes, microtubules, cytoskeleton, cell cycle, cancer, Drosophila.
Kat Hadjantonakis is a Member of the Sloan Kettering Institute of the Memorial Sloan Kettering Cancer Centre, New York and Professor at Cornell University, New York. She obtained her PhD from Imperial College, London. She undertook postdoctoral training first at the Samuel Lunenfeld Research Institute, Toronto, and subsequently at Columbia University, New York. She started her group at the Sloan Kettering Institute in 2004. Her research interests center on the coordination of cell fate decisions and morphogenetic mechanisms that make the early embryo. Kat’s lab primarily uses the mouse as a model system, but also exploits ex vivo stem cell paradigms where appropriate.
Areas of expertise: Mammalian embryogenesis, stem cells, mouse genetics, cell lineage, optical imaging, quantitative single-cell analyses.
John Speakman is Professor at the University of Aberdeen in Scotland, UK and also a Professor under the '1000 talents' program at the Institute of Genetics and Developmental Biology at the Chinese Academy of Sciences in Beijing, China. His main research interests revolve around the acquisition and utilisation of energy, and how a balance is struck between these processes. The key implications of this work include obesity and ageing. In addition, his research has also included considerable effort on ecophysiological aspects of small mammals, leading to the heat dissipation limit theory - a general theory governing limitations on maximal endotherm performance. He is a world authority on the use of stable isotope methods (notably the doubly labelled water method) to measure energy demands of free-living animals (and humans), and has active collaborations with more than 25 groups worldwide to apply this method. His recent work has included studies of the plateau pika on the high Tibetan plateau. He is a Fellow of the Royal Society of Edinburgh, the UK Academy of Medical Sciences and the Royal Society of the Arts.
Areas of expertise: Energetics, obesity, ageing.
Fanni is currently a Royal Society University Research Fellow at the Cancer Research UK Cambridge Research Institute, University of Cambridge. She completed her PhD with Jordan Raff at the Gurdon Institute in 2000. She then joined Colin Taylor's laboratory at Department of Pharmacology at the University of Cambridge as a postdoctoral fellow before returning to another stint to Jordan Raff's laboratory. She started her own group in 2006. She is interested in centrosome biology, in particular how centrosomes guide mitotic spindle assembly and what consequences deregulation of centrosomal proteins has on human diseases such as neurodevelopmental abnormalities and cancer.
Areas of expertise: Centrosomes, mitosis, microtubules, motors, cytoskeleton, cancer.
Jack is a Professor of Biology at the University of Nevada, Reno, where he has also served as Chair of the Biology Department and Associate Dean for Research. He completed his PhD at the University of California, Riverside, and postdocs at the University of Wisconsin, Madison, and the University of Aberdeen. Besides academia, Jack has worked in private industry and for the US National Science Foundation. His research is focused on the ecological and evolutionary physiology of vertebrates, especially mammals. His work often incorporates a genetic component and quantitative models, as well as both field and laboratory studies. Two of his major research foci have been (i) the ecology and evolution of aerobic metabolism and (ii) responses of mammals to hypoxia and high altitude. Recently, Jack has become interested in how physiology and evolutionary genetics may help inform biogeography and the effects of climate change. He hopes that, among other things, Biology Open can help provide open access to diverse data-rich papers documenting the effects of temperature on organismal biology, population biology and biogeography.
Areas of expertise: Allometry, aerobic metabolism, body condition, ecological and evolutionary physiology, endothermy, maximal metabolic rate.
Cathy Jackson is currently a Centre National de la Recherche Scientifique (CNRS) research director at the Institut Jacques Monod, Paris, France. She carried out doctoral studies in genetics at the University of Washington in Seattle, USA, with Leland H. Hartwell, and postdoctoral studies in the department of André Sentenac at the CEA, Saclay, France, in collaboration with the laboratory of Marc Chabre, IPMC, Nice, France.
Her laboratory is interested in the molecular mechanisms regulating vesicular and lipid trafficking in yeast and mammalian cells, a fundamental aspect of eukaryotic cellular organization.
Areas of expertise: Membrane dynamics, vesicular trafficking, lipid trafficking, lipid droplets, membrane contact sites.
Jin is a Professor in the Division of Biological Sciences and School of Medicine at the University of California, San Diego. She did her PhD with Kathryn Anderson at the University of California, Berkeley and was then a Jane Coffin Childs post-doctoral fellow with H. Robert Horvitz in the Department of Biology at Massachusetts Institute of Technology. She then moved back to California in 1996 to start up her own group at the UC Santa Cruz campus. She became an investigator of the Howard Hughes Medical Institute in 2001. Her lab moved to UC San Diego campus in 2007. She is interested in the development of the nervous systems, particularly using C. elegans genetics to investigate how synapses are formed and function. Recently, she has ventured into the genetic basis of adult neuronal regenerative ability. She was a recipient of the Presidential Early Career Award for Science and Engineering, and a fellow of the American Association for the Advancement of Sciences.
Areas of expertise: Genetics, neuronal development, synapses, axon regeneration, signal transduction, C. elegans.
Patricia Keely received her PhD in Cell and Developmental Biology from the University of Minnesota. She completed postdoctoral training at Washington University in St. Louis and The University of North Carolina-Chapel Hill. She is currently a Professor in the Department of Cellular and Regenerative Biology at the University of Wisconsin, Madison. Her laboratory investigates the interaction of tumor cells with the extracellular matrix. In particular, she seeks to understand the changes in collagen structure and organization that accompany, and may contribute to, tumor progression, and how cells respond to those changes, including cell invasion and migration through 3D matrices and in vivo, and integrin and Rho signaling pathways linked to mechanical signalling.
Areas of expertise: Cancer, extracellular matrix, signalling.
Steve is a Research Fellow in the Department of Plant Sciences at the University of Oxford. He did his PhD with Keith Gull and was then a post-doctoral fellow at the Oxford Centre for Integrative Systems Biology, before establishing his own group as a Leverhulme Early Career Fellow at the Department of Plant Sciences in Oxford. His group is interested in evolution and gene expression. They are primarily focused on plants as model systems, but branch out into humans and pathogens. They develop novel bioinformatic and computational methods, and combine these with experimental approaches to understand how gene expression is regulated and how this regulation has evolved. Their main focus is the evolution and regulation of C4 photosynthesis.
Areas of expertise: Evolution, bioinformatics, genomics, transcriptomics, gene expression regulation, computational biology, plant biology.
Jenny began her research career in early mammalian development with Richard Gardner at the University of Oxford. She then joined Austin Smith for a long and fruitful collaboration to develop strategies for efficient derivation of embryonic stem cells from murine embryos. She became a group leader at the Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute in 2006. Her group is interested in early mammalian development, in particular, how lineage decisions are made and how the embryo accommodates fluctuations in environment, signals and cell number to produce a foetus. The establishment of a population of cells that must protect itself from inappropriate differentiation, whilst retaining the capacity to respond to instructive cues in a timely manner is the main focus. To this end, the group studies genes associated with early embryonic lethality, mainly using genetic deletion and expression analysis. The group is also interested in early primate development and pluripotency.
Areas of expertise: Early mammalian development, stem cell derivation, embryonic cell potency, pluripotency networks.
Luca Scorrano (MD, PhD, University of Padua, Italy) is Director of the Venetian Institute of Molecular Medicine and Professor of Biochemistry, Department of Biology, University of Padua (Italy). Luca became interested in mitochondrial shape during his post-doc with the late Stan Korsmeyer (Harvard Medical School), when they discovered that mitochondrial cristae remodeling was involved in cytochrome c release and apoptosis. Since 2003, his lab, first in Italy, then in Geneva (Switzerland), where he was Professor at the Department of Cell Physiology and Metabolism for seven years, and from 2013 in Italy again, has investigated the molecular mechanisms and pathophysiological consequences of mitochondrial dynamics and tethering to the endoplasmic reticulum. He has received several prizes and awards (including the Eppendorf European Young Investigator, the Award Chiara D’Onofrio and the ESCI Award), is an EMBO Member and sits on several committees, Advisory and Editorial Boards.
Areas of expertise: Mitochondria, fusion-fission, apoptosis, autophagy, neurodegeneration, mouse models.