- miR-20a regulates proliferation, differentiation and apoptosis in P19 cell model of cardiac differentiation by targeting Smoothened
Summary: Our findings may bring a new viewpoint into the mechanisms of cardiac abnormalities and suggest that miR-20a may be a potential new therapeutic target for congenital heart diseases.
- Downregulation of leptin inhibits growth and induces apoptosis of lung cancer cells via the Notch and JAK/STAT3 signaling pathways
Summary: Leptin knockdown could become a new approach for the prevention of lung cancer progression, which we have shown is likely to be mediated by inactivation of the Notch and JAK/STAT3 signaling pathways.
- miR-22 inhibits mouse ovarian granulosa cell apoptosis by targeting SIRT1
Summary: Overexpression of miR-22 inhibits mGC apoptosis by targeting SIRT1, and knockdown of SIRT1 attenuated apoptosis in mGCs. Taken together, these findings provide an improved understanding of the molecular mechanisms of miR-22-mediated follicular development.