- Enhanced store-operated Ca2+ influx and ORAI1 expression in ventricular fibroblasts from human failing heart
Summary: The excessive collagen secretory phenotype found in failing human hearts is associated with ventricular fibroblast remodeling, caused by an elevated influx of intracellular calcium via SOC channels.
- Calcium homeostasis alterations in a mouse model of the Dynamin 2-related centronuclear myopathy
Summary: Dynamin 2 mutations cause centronuclear myopathy via unclear mechanisms. We show in a mouse model that changes in cytosolic calcium via incorrect membrane permeability correlate with muscle weakness.
- Expression and preliminary characterization of human MICU2
Summary: Ca2+ induces a monomer-dimer switch of MICU2, with the associated conformational change governed by its first EF-hand, but not influenced by the C-helix domain. A disulfide bond and salt bridge each contribute to MICU1-MICU2 heterodimer formation.