- Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal
Summary: Depletion of Lef1 and Tcf3 shows that ESCs could be shielded from differentiative cues to maintain the ESC ground state.
- miR-20a regulates proliferation, differentiation and apoptosis in P19 cell model of cardiac differentiation by targeting Smoothened
Summary: Our findings may bring a new viewpoint into the mechanisms of cardiac abnormalities and suggest that miR-20a may be a potential new therapeutic target for congenital heart diseases.
- Hindsight/RREB-1 functions in both the specification and differentiation of stem cells in the adult midgut of Drosophila
Summary: Hindsight, the Drosophila homolog of RREB-1, can promote and is required for enterocyte differentiation specifically in the adult midgut. Enterocyte differentiation during the larval/pupal transition does not require Hindsight.
- Differentiated muscles are mandatory for gas-filling of the Drosophila airway system
Summary: During embryogenesis in Drosophila melanogaster, without involving the nervous system, somatic muscles control terminal differentiation of the airway system by stimulating gas-filling before hatching.