Embryonic stem cells
- Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal
Summary: Depletion of Lef1 and Tcf3 shows that ESCs could be shielded from differentiative cues to maintain the ESC ground state.
- Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors
Summary: The findings here demonstrate that the signaling molecule retinoic acid (RA) plays an early role in determining how embryonic progenitor cells decide to differentiate into either mesodermal or neural tissues.