- Smad4 regulates growth plate matrix production and chondrocyte polarity
Summary: Smad4 is a key regulator of extracellular matrix production and chondrocyte proliferation, shape and orientation in the growth plate. Smad4 dysregulation results in skeletal dysplasias, such as Myhre syndrome.
- Hox11 genes regulate postnatal longitudinal bone growth and growth plate proliferation
Summary: Hox genes are required for postnatal skeletal growth. Hox11 genes function in the zeugopod skeletal elements and regulate longitudinal growth through controlling chondrocyte maturation within the growth plate.