- Xenopus laevis Kif18A is a highly processive kinesin required for meiotic spindle integrity
Summary: The highly processive kinesin Kif18A, which is expressed during oocyte maturation in Xenopus laevis, is required for correct spindle formation in meiotic egg extracts and can functionally complement human Kif18A in tissue culture cells.
- DRH1, a p68-related RNA helicase gene, is required for chromosome breakage in Tetrahymena
Summary: The p68-related Drh1protein is essential for both growth and development of the ciliate Tetrahymena thermophila. It localizes to meiotic nuclei and is required for chromosome breakage of developing somatic chromosomes.
- On the development of extragonadal and gonadal human germ cells
Summary: The presence and developmental trajectory of ectopic human germ cells in the adrenals and gonads during the first and second trimesters is investigated by comparing the expression dynamics of early, late and meiotic germ cell markers.
- Unique geometry of sister kinetochores in human oocytes during meiosis I may explain maternal age-associated increases in chromosomal abnormalities
Summary: Sister kinetochores in meiosis I human oocytes are not physically fused, with the degree of separation increasing with maternal age. This may have implications for the high incidence of aneuploidy in human oocytes.