- Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis
Summary: Induction of pulmonary microthrombosis by three distinct methods enhances HIF-a expression and tumour formation; increases in tumorigenesis that are induced by these thrombotic insults occur in a time- and mode-dependent manner.
- The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma
Summary: This paper demonstrates a functional link between a cancer-associated alteration to the tRNA repertoire and the invasive behaviour of cancer cells by demonstrating that increased tRNAimet can drive invasion and metastasis in melanoma cells.
- Changes in cell shape are correlated with metastatic potential in murine and human osteosarcomas
Summary: Human and murine invasive osteosarcoma cancer cell lines, developed by selection in vivo from a less invasive parental line, show distinguishable differences in shape from the parental line that fall into two categories: more mesenchymal or more amoeboid.