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Biology Open

Nox4, DNA methylation

RESEARCH ARTICLE

Gene silencing of Nox4 by CpG island methylation during hepatocarcinogenesis in rats
Guadalupe S. López-Álvarez, Tomasz K. Wojdacz, Claudia M. García-Cuellar, Hugo C. Monroy-Ramírez, Miguel A. Rodríguez-Segura, Ruth A. Pacheco-Rivera, Carlos A. Valencia-Antúnez, Nancy Cervantes-Anaya, Ernesto Soto-Reyes, Verónica R. Vásquez-Garzón, Yesennia Sánchez-Pérez, Saúl Villa-Treviño

Biology Open 2017 6: 59-70; doi: 10.1242/bio.020370

Summary: Many genes downregulated by DNA methylation are tumor suppressor genes. In the present study, DNA methylation of Nox4 is observed, with implications for Nox4 as a potential therapeutic target for liver or other cancers.