- Smad4 regulates growth plate matrix production and chondrocyte polarity
Summary: Smad4 is a key regulator of extracellular matrix production and chondrocyte proliferation, shape and orientation in the growth plate. Smad4 dysregulation results in skeletal dysplasias, such as Myhre syndrome.
- Automated image analysis reveals the dynamic 3-dimensional organization of multi-ciliary arrays
Summary: We develop an automated computational image analysis routine to quantify basal body organization, which detects subtle spatial phenotypes resulting from environmental and genetic perturbations.