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  Open access

February, 2021; 10 (2)

FUTURE LEADER REVIEW

  • Open Access
    Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics
    Manuel Schmid, Christopher N. Toepfer
    Biology Open 2021 10: bio057646 doi: 10.1242/bio.057646 Published 15 February 2021

    Summary: A discussion of the role and regulation of myosin super relaxation in biology, evolution, human disease, and cardiac therapeutics.

RESEARCH ARTICLES

  • Open Access
    Stability of amino acids and related amines in human serum under different preprocessing and pre-storage conditions based on iTRAQ®-LC-MS/MS
    Zhuoling An, Chen Shi, Pengfei Li, Lihong Liu
    Biology Open 2021 10: bio055020 doi: 10.1242/bio.055020 Published 26 February 2021

    Summary: We investigated the stability of amino acids in serum samples that underwent prolonged storage at 4°C and 22°C, and repeated freeze-thaw cycles at −80°C using stable isotope iTRAQ labeling and liquid chromatography tandem mass spectrometry.

  • Open Access
    Segregation of brain and organizer precursors is differentially regulated by Nodal signaling at blastula stage
    Aitana M. Castro Colabianchi, María B. Tavella, Laura E. Boyadjián López, Marcelo Rubinstein, Lucía F. Franchini, Silvia L. López
    Biology Open 2021 10: bio051797 doi: 10.1242/bio.051797 Published 25 February 2021

    Summary: Nodal signaling is involved in the delimitation of the blastula cell populations that give rise to the brain and axial mesoderm in Xenopus.

  • Open Access
    Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways
    Grace X. Li, Shaobing Zhang, Ren Liu, Bani Singh, Sukhmani Singh, David I. Quinn, Gage Crump, Parkash S. Gill
    Biology Open 2021 10: bio050096 doi: 10.1242/bio.050096 Published 25 February 2021

    Summary: Tspan18 is a transmembrane protein with highly restricted expression in endothelial cells and a critical regulator of VEGF and Notch pathways. It regulates artery–vein specification, vessel patterning and vessel stability.

  • Open Access
    Unique histological features of the tail skin of cotton rat (Sigmodon hispidus) related to caudal autotomy
    Marina Hosotani, Teppei Nakamura, Osamu Ichii, Takao Irie, Yuji Sunden, Yaser Hosny Ali Elewa, Takafumi Watanabe, Hiromi Ueda, Takashi Mishima, Yasuhiro Kon
    Biology Open 2021 10: bio058230 doi: 10.1242/bio.058230 Published 19 February 2021

    Summary: The unique histological structures in derimis, subcutis and coccygeal artery of the tail skin are related to the caudal autotomy mechanism in the cotton rat.

  • Open Access
    Sex differences in postprandial blood glucose and body surface temperature are contingent on flight in the fruit bat, Cynopterus sphinx
    Venkatesh Nagarajan-Radha, Paramanantha Swami Doss Devaraj
    Biology Open 2021 10: bio053926 doi: 10.1242/bio.053926 Published 17 February 2021

    Summary: The level of sex differences in metabolic traits is affected by flight in Cynopterus sphinx, a finding that has general implications for sex-specific life-history evolution in fruit bats.

  • Open Access
    Smoking flies: testing the effect of tobacco cigarettes on heart function of Drosophila melanogaster
    Manuela Santalla, Lucía Pagola, Ivana Gómez, Darío Balcazar, Carlos A. Valverde, Paola Ferrero
    Biology Open 2021 10: bio055004 doi: 10.1242/bio.055004 Published 15 February 2021

    Summary: Nicotine, a substance present in tobacco, resembles insecticide compounds such as neonicotinoids, and affects the heart function in Drosophila melanogaster.

  • Open Access
    Single-cell sequencing reveals the potential oncogenic expression atlas of human iPSC-derived cardiomyocytes
    Minglin Ou, Min Zhao, Chunhong Li, Donge Tang, Yong Xu, Weier Dai, Weiguo Sui, Yue Zhang, Zhen Xiang, Chune Mo, Hua Lin, Yong Dai
    Biology Open 2021 10: bio053348 doi: 10.1242/bio.053348 Published 15 February 2021

    Summary: The single-cell expression atlas in the cardiomyocytes generated from human iPSCs provide potential carcinogenic information for the clinical application of human iPSC-derived cells.

  • Open Access
    Quantified growth of the human embryonic heart
    Jaeike W. Faber, Jaco Hagoort, Antoon F. M. Moorman, Vincent M. Christoffels, Bjarke Jensen
    Biology Open 2021 10: bio057059 doi: 10.1242/bio.057059 Published 10 February 2021

    Summary: This paper provides quantitative data on the growth of 58 structures of the human embryonic heart between weeks 4 and 8 of development.

  • Open Access
    Dissecting dynamics and differences of selective pressures in the evolution of human pigmentation
    Xin Huang, Sijia Wang, Li Jin, Yungang He
    Biology Open 2021 10: bio056523 doi: 10.1242/bio.056523 Published 9 February 2021

    Summary: This study developed a novel approach to estimate selection strength over time and applied it on the evolution of human pigmentation.

  • Open Access
    A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and Notch signaling
    Katherine K. Slemmons, Michael D. Deel, Yi-Tzu Lin, Kristianne M. Oristian, Nina Kuprasertkul, Katia C. Genadry, Po-Han Chen, Jen-Tsan Ashley Chi, Corinne M. Linardic
    Biology Open 2021 10: bio050211 doi: 10.1242/bio.050211 Published 9 February 2021

    Summary: Here we report on a method to culture human PAX3-FOXO1 fusion-positive rhabdomyosarcoma cells in three dimensions, and use these rhabdospheres as a novel tool to study their stemness and chemoresistance signaling mechanisms.

  • Open Access
    Auxin confers protection against ER stress in Caenorhabditis elegans
    Anupam Bhoi, Francesca Palladino, Paola Fabrizio
    Biology Open 2021 10: bio057992 doi: 10.1242/bio.057992 Published 3 February 2021

    Summary: Auxin, commonly used to induce conditional protein degradation, promotes ER stress resistance in C. elegans through the unfolded protein response (UPR).

  • Open Access
    A modifier screen identifies regulators of cytoskeletal architecture as mediators of Shroom-dependent changes in tissue morphology
    Jeffrey D. Hildebrand, Adam D. Leventry, Omoregie P. Aideyman, John C. Majewski, James A. Haddad, Dawn C. Bisi, Nancy Kaufmann
    Biology Open 2021 10: bio055640 doi: 10.1242/bio.055640 Published 3 February 2021

    Summary: Using Drosophila as a model system, we identify F-actin and microtubules as important determinants of how cells and tissues respond to Shroom induced contractility.

METHODS & TECHNIQUES

  • Open Access
    Three-dimensional model of glioblastoma by co-culturing tumor stem cells with human brain organoids
    Roberta Azzarelli, Michela Ori, Anna Philpott, Benjamin D. Simons
    Biology Open 2021 10: bio056416 doi: 10.1242/bio.056416 Published 22 February 2021

    Summary: We describe a method to co-culture glioblastoma stem cells with human cerebral organoids in order to model tumor complexity and recapitulate cellular heterogeneity in vitro.

  • Open Access
    Monitoring Schizosaccharomyces pombe genome stress by visualizing end-binding protein Ku
    Chance E. Jones, Susan L. Forsburg
    Biology Open 2021 10: bio054346 doi: 10.1242/bio.054346 Published 15 February 2021

    Summary: The authors describe a fluorescently tagged Ku70 protein to monitor replication stress in live S. pombe cells.

  • Open Access
    Design of a 3D printed, motorized, uniaxial cell stretcher for microscopic and biochemical analysis of mechanotransduction
    Noor A. Al-Maslamani, Abdulghani A. Khilan, Henning F. Horn
    Biology Open 2021 10: bio057778 doi: 10.1242/bio.057778 Published 10 February 2021

    Summary: Description and testing of a 3D printed uniaxial stretcher designed for the microscopic and biochemical analysis of mammalian cells subjected to mechanical stretch.

FIRST PERSON

  • Open Access
    First person – Aitana Manuela Castro Colabianchi
    Biology Open 2021 10: bio058656 doi: 10.1242/bio.058656 Published 2 March 2021
  • Open Access
    First person – Roberta Azzarelli
    Biology Open 2021 10: bio058609 doi: 10.1242/bio.058609 Published 22 February 2021
  • Open Access
    First person – Jaeike Faber
    Biology Open 2021 10: bio058592 doi: 10.1242/bio.058592 Published 15 February 2021
  • Open Access
    First person – Manuela Santalla
    Biology Open 2021 10: bio058569 doi: 10.1242/bio.058569 Published 15 February 2021
  • Open Access
    Future Leaders to Watch – Christopher Toepfer and Manuel Schmid
    Biology Open 2021 10: bio058568 doi: 10.1242/bio.058568 Published 15 February 2021
  • Open Access
    First person – Xin Huang
    Biology Open 2021 10: bio058547 doi: 10.1242/bio.058547 Published 9 February 2021
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  • Open Access

    A Caenorhabditis elegans Behavioral Assay Distinguishes Early Stage Prostate Cancer Patient Urine from Controls

    Morgan Thompson, Noemi Sarabia Feria, Ally Yoshioka, Eugene Tu, Fehmi Civitci, Suzanne Estes, Josiah T. Wagner
    PDF
  • Open Access

    Integrated Analysis of Cell Shape and Movement in Moving Frame

    Yusri Dwi Heryanto, Chin-Yi Cheng, Yutaka Uchida, Kazushi Mimura, Masaru Ishii, Ryo Yamada
    PDF
  • Open Access

    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
    PDF
  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
    PDF
  • Open Access

    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
    PDF
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Biology Open and COVID-19

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Future Leader Review - Cardiac myosin super relaxation

A new Future Leader Review by Manuel Schmid and Christopher Toepfer discusses the rapidly-expanding field of myosin super relaxation in the context of cardiovascular disease. Read the full Review and their accompanying interview.

Find out more about our Future Leader Reviews – they are an exclusive opportunity for early-career researchers who want to establish themselves in their field.


An interview with Roberta Azzarelli

In an interview, first author Roberta Azzarelli discusses her 3D model of glioblastoma and shares her thoughts on how to improve the professional lives of early-career researchers: formal mentorship programmes, a clearly structured career path and taking part in initiatives such as the Node Network.


News from our sister journals

Development continues to run a successful new webinar series, Development presents…, while Journal of Cell Science has recently welcomed Esperanza Agullo-Pascual as FocalPlane’s new Community Manager. Journal of Experimental Biology’s new special issue highlights the role of comparative biology in tackling climate change and Liz Patton, the new Editor-in-Chief of Disease Models & Mechanisms, sets out her visions and priorities.

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