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Research Article
Single site-specific integration targeting coupled with embryonic stem cell differentiation provides a high-throughput alternative to in vivo enhancer analyses
Adam C. Wilkinson, Debbie K. Goode, Yi-Han Cheng, Diane E. Dickel, Sam Foster, Tim Sendall, Marloes R. Tijssen, Maria-Jose Sanchez, Len A. Pennacchio, Aileen M. Kirkpatrick, Berthold Göttgens
Biology Open 2013 2: 1229-1238; doi: 10.1242/bio.20136296
Adam C. Wilkinson
1Cambridge Institute for Medical Research and Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
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Debbie K. Goode
1Cambridge Institute for Medical Research and Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
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Yi-Han Cheng
1Cambridge Institute for Medical Research and Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
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Diane E. Dickel
2Genomics Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS84-171, Berkeley, CA 94720, USA
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Sam Foster
1Cambridge Institute for Medical Research and Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
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Tim Sendall
1Cambridge Institute for Medical Research and Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
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Marloes R. Tijssen
1Cambridge Institute for Medical Research and Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
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Maria-Jose Sanchez
3Centro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide, Seville 41013, Spain
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Len A. Pennacchio
2Genomics Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS84-171, Berkeley, CA 94720, USA
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Aileen M. Kirkpatrick
1Cambridge Institute for Medical Research and Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
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  • For correspondence: amkirkpatrick73@gmail.com bg200@cam.ac.uk
Berthold Göttgens
1Cambridge Institute for Medical Research and Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
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  • For correspondence: amkirkpatrick73@gmail.com bg200@cam.ac.uk
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Article Information

vol. 2 no. 11, 1229-1238

DOI 
https://doi.org/10.1242/bio.20136296
PubMed 
24244860

Published By 
The Company of Biologists Ltd
Online ISSN 
2046-6390
History 
  • Received July 30, 2013
  • Accepted September 9, 2013
  • Published online November 15, 2013.
Posted online 
October 18, 2013
Copyright & Usage 
© 2013. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Article Versions

  • Previous version (October 18, 2013 - 04:26).
  • You are viewing the most recent version of this article.

Author Information

  1. Adam C. Wilkinson1,*,
  2. Debbie K. Goode1,*,
  3. Yi-Han Cheng1,*,
  4. Diane E. Dickel2,
  5. Sam Foster1,
  6. Tim Sendall1,
  7. Marloes R. Tijssen1,
  8. Maria-Jose Sanchez3,
  9. Len A. Pennacchio2,
  10. Aileen M. Kirkpatrick1,‡ and
  11. Berthold Göttgens1,‡
  1. 1Cambridge Institute for Medical Research and Wellcome Trust–MRC Cambridge Stem Cell Institute, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
  2. 2Genomics Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS84-171, Berkeley, CA 94720, USA
  3. 3Centro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide, Seville 41013, Spain
  1. ↵‡Authors for correspondence (amkirkpatrick73{at}gmail.com; bg200{at}cam.ac.uk)
  1. ↵* These authors contributed equally to this work

Article usage

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Keywords

  • ES cells
  • Enhancer
  • Haematopoiesis
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Research Article
Single site-specific integration targeting coupled with embryonic stem cell differentiation provides a high-throughput alternative to in vivo enhancer analyses
Adam C. Wilkinson, Debbie K. Goode, Yi-Han Cheng, Diane E. Dickel, Sam Foster, Tim Sendall, Marloes R. Tijssen, Maria-Jose Sanchez, Len A. Pennacchio, Aileen M. Kirkpatrick, Berthold Göttgens
Biology Open 2013 2: 1229-1238; doi: 10.1242/bio.20136296
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Research Article
Single site-specific integration targeting coupled with embryonic stem cell differentiation provides a high-throughput alternative to in vivo enhancer analyses
Adam C. Wilkinson, Debbie K. Goode, Yi-Han Cheng, Diane E. Dickel, Sam Foster, Tim Sendall, Marloes R. Tijssen, Maria-Jose Sanchez, Len A. Pennacchio, Aileen M. Kirkpatrick, Berthold Göttgens
Biology Open 2013 2: 1229-1238; doi: 10.1242/bio.20136296

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