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  You have access

  Open access

December, 2015; 4 (12)

EDITORIAL

  • Open Access
    Biology Open: evaluating impact
    Rachel Hackett, O. Claire Moulton, Jordan W. Raff
    Biology Open 2015 4: 1609-1613; doi: 10.1242/bio.016147

RESEARCH ARTICLES

  • Open Access
    Fine-tuning the onset of myogenesis by homeobox proteins that interact with the Myf5 limb enhancer
    Philippe Daubas, Nathalie Duval, Lola Bajard, Francina Langa Vives, Benoît Robert, Baljinder S. Mankoo, Margaret Buckingham
    Biology Open 2015 4: 1614-1624; doi: 10.1242/bio.014068

    Summary: Homeodomain factors Msx1 and Meox2, acting in addition to Pax3 and Six1/4, fine-tune the entry of progenitor cells into myogenesis at early stages of forelimb development via modulation of limb enhancer gene Myf5.

  • Open Access
    Epithelial topography for repetitive tooth formation
    Marcia Gaete, Juan Manuel Fons, Elena Mădălina Popa, Lemonia Chatzeli, Abigail S. Tucker
    Biology Open 2015 4: 1625-1634; doi: 10.1242/bio.013672

    Summary: This study proposes a model for repetitive tooth formation in which the epithelium can grow by the movement of epithelial cells followed by infolding and stratification of Sox2/Sox9 positive cells.

  • Open Access
    Muscle activation during maximal effort tasks: evidence of the selective forces that shaped the musculoskeletal system of humans
    David R. Carrier, Nadja Schilling, Christoph Anders
    Biology Open 2015 4: 1635-1642; doi: 10.1242/bio.014381

    Summary: In this study, we identified behaviors that produce maximum activation of muscles to test hypotheses of the specific behaviors that influenced the evolution of the human musculoskeletal system.

  • Open Access
    Tarantulas (Araneae: Theraphosidae) use different adhesive pads complementarily during climbing on smooth surfaces: experimental approach in eight arboreal and burrower species
    Fernando Pérez-Miles, Carlos Perafán, Laura Santamaría
    Biology Open 2015 4: 1643-1648; doi: 10.1242/bio.013144

    Summary: We test friction as a proxy of adhesion, comparing arboreal and burrower tarantulas climbing on different surfaces and at different angles.

  • Open Access
    The nature of alarm communication in Constrictotermes cyphergaster (Blattodea: Termitoidea: Termitidae): the integration of chemical and vibroacoustic signals
    Paulo F. Cristaldo, Vojtĕch Jandák, Kateřina Kutalová, Vinícius B. Rodrigues, Marek Brothánek, Ondřej Jiříček, Og DeSouza, Jan Šobotník
    Biology Open 2015 4: 1649-1659; doi: 10.1242/bio.014084

    Summary: We inspected the functional significance of both vibroacoustic and chemical communication channels in Constrictotermes cyphergaster (Termitidae: Nasutitermitinae), confirming the hypothesis that these are not exclusive but rather complementary processes.

  • Open Access
    N-docosahexaenoylethanolamine regulates Hedgehog signaling and promotes growth of cortical axons
    Giorgi Kharebava, Mohammad A. Rashid, Ji-Won Lee, Sarmila Sarkar, Karl Kevala, Hee-Yong Kim
    Biology Open 2015 4: 1660-1670; doi: 10.1242/bio.013425

    Summary: Synaptamide, an omega-3 fatty acid metabolite, promotes axon growth while Shh antagonizes synaptamide-mediated axon growth by a SMO-independent, non-canonical pathway.

  • Open Access
    1H NMR metabolic profiling of cod (Gadus morhua) larvae: potential effects of temperature and diet composition during early developmental stages
    Matilde Skogen Chauton, Trina Falck Galloway, Elin Kjørsvik, Trond Røvik Størseth, Velmurugu Puvanendran, Terje van der Meeren, Ørjan Karlsen, Ivar Rønnestad, Kristin Hamre
    Biology Open 2015 4: 1671-1678; doi: 10.1242/bio.014431

    Summary: Metabolomic ‘snapshots’ from developing cod larvae reflect the temperature and diet experienced from hatching to juvenile and provide insight into how important processes such as osmoregulation and muscle development might be affected.

  • Open Access
    Novel myristoylation of the sperm-specific hexokinase 1 isoform regulates its atypical localization
    Sujeet Kumar, Sreejit Parameswaran, Rajendra K. Sharma
    Biology Open 2015 4: 1679-1687; doi: 10.1242/bio.012831

    Summary: Dual acylation (i.e. myristoylation and palmitoylation) regulates the atypical localization of sperm-specific hexokinase 1 isoform and thus is essential for ‘rewiring’ of glycolytic network.

  • Open Access
    Functional brain regeneration in the acoel worm Symsagittifera roscoffensis
    Simon G. Sprecher, F. Javier Bernardo-Garcia, Lena van Giesen, Volker Hartenstein, Heinrich Reichert, Ricardo Neves, Xavier Bailly, Pedro Martinez, Michael Brauchle
    Biology Open 2015 4: 1688-1695; doi: 10.1242/bio.014266

    Summary: Brain and head regeneration in the acoel Symsagittifera roscoffensis is coordinated with restoration of directed navigation behavior, suggesting that the regenerative capacity of different sensory modalities follows distinct paths. 

  • Open Access
    Dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways
    Anna Melkov, Yasmin Simchoni, Yehonatan Alcalay, Uri Abdu
    Biology Open 2015 4: 1696-1706; doi: 10.1242/bio.015206

    Summary: Highly polarized Drosophila bristle cells reveal that dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways, and a novel mode of coordination between Khc and Dhc in mitochondrial transport.

  • Open Access
    The expression of the T-box selector gene midline in the leg imaginal disc is controlled by both transcriptional regulation and cell lineage
    Pia C. Svendsen, Jae-Ryeon Ryu, William J. Brook
    Biology Open 2015 4: 1707-1714; doi: 10.1242/bio.013565

    Summary: Leg expression of the selector gene midline in Drosophila is controlled both by transcriptional regulation and by the lack of mixing between dorsal and ventral cells in the distal leg.

  • Open Access
    The invisible fish: hydrodynamic constraints for predator-prey interaction in fossil fish Saurichthys compared to recent actinopterygians
    Ilja Kogan, Steffen Pacholak, Martin Licht, Jörg W. Schneider, Christoph Brücker, Sebastian Brandt
    Biology Open 2015 4: 1715-1726; doi: 10.1242/bio.014720

    Summary: For the first time, the hydrodynamic properties of a fossil fish, Saurichthys, have been investigated using computational fluid dynamics. Low drag coefficient and small area of flow disturbance prove fast-start predatory adaptation.

  • Open Access
    Different ossification patterns of intermuscular bones in fish with different swimming modes
    Wenjie Yao, Yaoping Lv, Xiaoling Gong, Jiaming Wu, Baolong Bao
    Biology Open 2015 4: 1727-1732; doi: 10.1242/bio.012856

    Summary: The ossification of intermuscular bones in teleost fish appears to be induced by mechanical force loadings produced by swimming.

  • Open Access
    The primary cilium is a self-adaptable, integrating nexus for mechanical stimuli and cellular signaling
    An M. Nguyen, Y.-N. Young, Christopher R. Jacobs
    Biology Open 2015 4: 1733-1738; doi: 10.1242/bio.014787

    Summary: Primary cilia stiffness can be modulated, affecting the cellular responsiveness to mechanical signals. We identify a potential mechanism that regulates cellular mechanosensitivity.

  • Open Access
    S phase block following MEC1ATR inactivation occurs without severe dNTP depletion
    Caroline Earp, Samuel Rowbotham, Gábor Merényi, Andrei Chabes, Rita S. Cha
    Biology Open 2015 4: 1739-1743; doi: 10.1242/bio.015347

    Summary: This study, using a temperature sensitive mec1 mutant, reveals that inactivation of Mec1 leads to S phase arrest, and that genome duplication in the absence of Mec1/ATR is exquisitely sensitive to small changes in dNTP levels.

  • Open Access
    Urine-derived induced pluripotent stem cells as a modeling tool for paroxysmal kinesigenic dyskinesia
    Shu-Zhen Zhang, Hong-Fu Li, Li-Xiang Ma, Wen-Jing Qian, Zhong-Feng Wang, Zhi-Ying Wu
    Biology Open 2015 4: 1744-1752; doi: 10.1242/bio.013078

    Summary: This is the first report of urinary cell-induced pluripotent stem cells being used as resources for investigation of the pathological mechanisms of paroxysmal kinesigenic dyskinesia.

  • Open Access
    Differentiated muscles are mandatory for gas-filling of the Drosophila airway system
    Yiwen Wang, Tina Cruz, Uwe Irion, Bernard Moussian
    Biology Open 2015 4: 1753-1761; doi: 10.1242/bio.013086

    Summary: During embryogenesis in Drosophila melanogaster, without involving the nervous system, somatic muscles control terminal differentiation of the airway system by stimulating gas-filling before hatching.

  • Open Access
    Introducing Pitt-Hopkins syndrome-associated mutations of TCF4 to Drosophila daughterless
    Laura Tamberg, Mari Sepp, Tõnis Timmusk, Mari Palgi
    Biology Open 2015 4: 1762-1771; doi: 10.1242/bio.014696

    Summary: Introducing mutations of the TCF4 gene found in human patients into its fly orthologue daughterless allows the generation of Drosophila models for research into Pitt-Hopkins syndrome.

  • Open Access
    Analysis of neural progenitors from embryogenesis to juvenile adult in Xenopus laevis reveals biphasic neurogenesis and continuous lengthening of the cell cycle
    Raphaël Thuret, Hélène Auger, Nancy Papalopulu
    Biology Open 2015 4: 1772-1781; doi: 10.1242/bio.013391

    Summary: Our work represents the first continuous analysis of neural progenitor behaviour in X. laevis from early embryogenesis to juvenile stage and identifies two phases of neurogenesis interrupted by a phase of slow increase of the progenitor pool.

  • Open Access
    Apical constriction and epithelial invagination are regulated by BMP activity
    Vijay K. Jidigam, Raghuraman C. Srinivasan, Cedric Patthey, Lena Gunhaga
    Biology Open 2015 4: 1782-1791; doi: 10.1242/bio.015263

    Summary: We describe a novel role for BMP activity in promoting a direct and cell type-independent mechanism for apical constriction, cell elongation and epithelial invagination, separate from acquisition of placode-specific identities.

  • Open Access
    The LINC complex component Sun4 plays a crucial role in sperm head formation and fertility
    Elisabeth Pasch, Jana Link, Carolin Beck, Stefanie Scheuerle, Manfred Alsheimer
    Biology Open 2015 4: 1792-1802; doi: 10.1242/bio.015768

    Summary: SUN-domain protein Sun4 is essential for sperm head formation. Sun4 deficiency interferes with the organization of the microtubule manchette and leads to a globozoospermia-like phenotype and infertility.

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    Integrated Analysis of Cell Shape and Movement in Moving Frame

    Yusri Dwi Heryanto, Chin-Yi Cheng, Yutaka Uchida, Kazushi Mimura, Masaru Ishii, Ryo Yamada
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  • Open Access

    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
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  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
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    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
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    The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)

    Kun Guo, Jun Zhong, Lin Zhu, Fan Xie, Yu Du, Xiang Ji
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