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  You have access

  Open access

October, 2016; 5 (10)

RESEARCH ARTICLES

  • Open Access
    Refilins are short-lived Actin-bundling proteins that regulate lamellipodium protrusion dynamics
    Olivia Gay, Benoît Gilquin, Nicole Assard, Pascal Stuelsatz, Christian Delphin, Joël Lachuer, Xavier Gidrol, Jacques Baudier
    Biology Open 2016 5: 1351-1361; doi: 10.1242/bio.019588

    Summary: The newly identified Refilin protein family are unique short-lived proteins that complex with Filamin to regulate plasma membrane dynamics though the promotion of Actin filament bundling.

  • Open Access
    Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability
    Emma L. Wilkinson, James E. Sidaway, Michael J. Cross
    Biology Open 2016 5: 1362-1370; doi: 10.1242/bio.020362

    Summary: The anti-cancer drugs doxorubicin and Herceptin can disrupt tight junction formation in cardiac microvascular endothelial cells resulting in increased permeability which could potentially contribute to drug-induced cardiotoxicity.

  • Open Access
    The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma
    Joanna Birch, Cassie J. Clarke, Andrew D. Campbell, Kirsteen Campbell, Louise Mitchell, Dritan Liko, Gabriela Kalna, Douglas Strathdee, Owen J. Sansom, Matthew Neilson, Karen Blyth, Jim C. Norman
    Biology Open 2016 5: 1371-1379; doi: 10.1242/bio.019075

    Summary: This paper demonstrates a functional link between a cancer-associated alteration to the tRNA repertoire and the invasive behaviour of cancer cells by demonstrating that increased tRNAimet can drive invasion and metastasis in melanoma cells.

  • Open Access
    Matriptase and prostasin are expressed in human skin in an inverse trend over the course of differentiation and are targeted to different regions of the plasma membrane
    Chih-Hsin Lai, Shun-Cheng Chang, Yen-Ju Chen, Yi-Jie J. Wang, Ying-Jun J. Lai, Hsiang-Hua D. Chang, Eric B. Berens, Michael D. Johnson, Jehng-Kang Wang, Chen-Yong Lin
    Biology Open 2016 5: 1380-1387; doi: 10.1242/bio.019745

    Summary: The inverse expression pattern between matriptase and prostasin during differentiation in human skin demonstrated here provides a stark contrast to their close functional link suggested from mouse models.

  • Open Access
    The decapping activator Edc3 and the Q/N-rich domain of Lsm4 function together to enhance mRNA stability and alter mRNA decay pathway dependence in Saccharomyces cerevisiae
    Susanne Huch, Maren Müller, Mridula Muppavarapu, Jessie Gommlich, Vidya Balagopal, Tracy Nissan
    Biology Open 2016 5: 1388-1399; doi: 10.1242/bio.020487

    Summary: A strain mutated in two decapping activators, previously implicated in P body assembly, has reduced mRNA stability and increased dependence on decapping and Ccr4-dependent deadenylation for mRNA degradation.

  • Open Access
    Changes in fatty acid composition in the giant clam Tridacna maxima in response to thermal stress
    Vaimiti Dubousquet, Emmanuelle Gros, Véronique Berteaux-Lecellier, Bruno Viguier, Phila Raharivelomanana, Cédric Bertrand, Gaël J. Lecellier
    Biology Open 2016 5: 1400-1407; doi: 10.1242/bio.017921

    Summary: Lipid remodelling according to the gene expression of Tridacna maxima and the fate of its symbiont Symbiodinium may contribute to its resistance during thermal stress.

  • Open Access
    Walking economy at simulated high altitude in human healthy young male lowlanders
    Masahiro Horiuchi, Yoko Handa, Daijiro Abe, Yoshiyuki Fukuoka
    Biology Open 2016 5: 1408-1414; doi: 10.1242/bio.019810

    Summary: Acute severe hypoxia slowed the economical speed (ES) which can minimize energy cost of walking. Muscle O2 extraction may be one of the determining factors of an individual's ES.

  • Open Access
    Maximum swimming speeds of sailfish and three other large marine predatory fish species based on muscle contraction time and stride length: a myth revisited
    Morten B. S. Svendsen, Paolo Domenici, Stefano Marras, Jens Krause, Kevin M. Boswell, Ivan Rodriguez-Pinto, Alexander D. M. Wilson, Ralf H. J. M. Kurvers, Paul E. Viblanc, Jean S. Finger, John F. Steffensen
    Biology Open 2016 5: 1415-1419; doi: 10.1242/bio.019919

    Summary: Using muscle contraction measurements, this work provides evidence that sailfish are most likely unable to reach the extremely high speeds claimed by previous research and popular articles.

  • Open Access
    The roles of Syx5 in Golgi morphology and Rhodopsin transport in Drosophila photoreceptors
    Takunori Satoh, Yuri Nakamura, Akiko K. Satoh
    Biology Open 2016 5: 1420-1430; doi: 10.1242/bio.020958

    Summary: Unlike Rab6-deficiency which affects only apical transport pathways, Syx5-deficiency inhibits all of polarized transport pathways, implying that these two genes are working in distinct stages of intra-Golgi transport.

  • Open Access
    Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation
    Oliver Wueseke, David Zwicker, Anne Schwager, Yao Liang Wong, Karen Oegema, Frank Jülicher, Anthony A. Hyman, Jeffrey B. Woodruff
    Biology Open 2016 5: 1431-1440; doi: 10.1242/bio.020990

    Summary: Polo-like kinase phosphorylation determines proper centrosome scaffold size and density, but not function or maintenance, in Caenorhabditis elegans embryos.

  • Open Access
    Synergistic inhibition of the APC/C by the removal of APC15 in HCT116 cells lacking UBE2C
    Dimitriya H. Garvanska, Marie Sofie Yoo Larsen, Jakob Nilsson
    Biology Open 2016 5: 1441-1448; doi: 10.1242/bio.020842

    Summary: The activation of the anaphase-promoting complex drives mitotic exit and here mechanistic aspects of this are explored using CRISPR/Cas9 genetically engineered human null cell lines.

  • Open Access
    Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases
    Fei Lu, Xiaojun Wu, Feng Yin, Christina Chia-Fang Lee, Min Yu, Ivailo S. Mihaylov, Jiekai Yu, Hong Sun, Hui Zhang
    Biology Open 2016 5: 1449-1460; doi: 10.1242/bio.019729

    Summary: DNA replication or re-replication of DNA induced after loss of Geminin or CLR4CDT2 is regulated by the methylation activities of the MLL-WDR5-RBBP5 methyltransferases on histone H3 at lysine 4 (H3K4).

  • Open Access
    αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish
    Mitchell K. L. Han, Esteban Hoijman, Emily Nöel, Laurence Garric, Jeroen Bakkers, Johan de Rooij
    Biology Open 2016 5: 1461-1472; doi: 10.1242/bio.021378

    Summary: Cadherin adhesions transduce tension across the junction-actomyosin axis into proportional biochemical responses via α-catenin. Here we show for the first time how this function of the cadherin complex is important during zebrafish morphogenesis.

  • Open Access
    Zebrafish P54 RNA helicases are cytoplasmic granule residents that are required for development and stress resilience
    Cecilia Zampedri, Maryana Tinoco-Cuellar, Samantha Carrillo-Rosas, Abigail Diaz-Tellez, Jose Luis Ramos-Balderas, Francisco Pelegri, Ernesto Maldonado
    Biology Open 2016 5: 1473-1484; doi: 10.1242/bio.015826

    Summary: Stress granules are formed by mRNAs stalled in translation during stress conditions. P54 RNA helicases from zebrafish reside in cytoplasmic granules and are essential for heat-shock resilience.

  • Open Access
    Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells
    T. Goullet de Rugy, M. Bashkurov, A. Datti, R. Betous, L. Guitton-Sert, C. Cazaux, D. Durocher, J. S. Hoffmann
    Biology Open 2016 5: 1485-1492; doi: 10.1242/bio.018028

    Summary: Our work suggests that Polθ upregulation may be crucial for homologous recombination (HR)-proficient cells to better tolerate DNA replication stress, as part of a global gene deregulation response, including HR genes.

  • Open Access
    Mytilus galloprovincialis as a smart micro-pump
    Fazil E. Uslu, Kerem Pekkan
    Biology Open 2016 5: 1493-1499; doi: 10.1242/bio.021048

    Summary: The common Mediterranean mussel, Mytilus galloprovincialis, efficiently generates low Reynolds number inhalant suction flow and unique time-dependent exhalant jet structures.

  • Open Access
    Dining dichotomy: aquatic and terrestrial prey capture behavior in the Himalayan newt Tylototriton verrucosus
    Egon Heiss, Marie De Vylder
    Biology Open 2016 5: 1500-1507; doi: 10.1242/bio.020925

    Summary: Tylototriton verrucosus uses lingual prehension for terrestrial prey capture and switches to suction feeding for aquatic strikes. This flexible prey capture behavior enables efficient food acquisition in two very different habitats.

  • Open Access
    The leptin system and its expression at different nutritional and pregnant stages in lined seahorse (Hippocampus erectus)
    Huixian Zhang, Geng Qin, Yanhong Zhang, Shuisheng Li, Qiang Lin
    Biology Open 2016 5: 1508-1515; doi: 10.1242/bio.020750

    Summary: This study provided insights into the function of the leptin system in energy metabolism regulation and male pregnancy in lined seahorse (Hippocampus erectus).

  • Open Access
    LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes
    Virginie Hubert, Andrea Peschel, Brigitte Langer, Marion Gröger, Andrew Rees, Renate Kain
    Biology Open 2016 5: 1516-1529; doi: 10.1242/bio.018648

    Summary: LAMP-2 is required for autophagosome-lysosome fusion. Its absence does not affect the lysosomal SNARE VAMP8 while its interacting partner STX17 is absent from the autophagosomes providing a molecular explanation for this fusion failure.

  • Open Access
    Amontillado is required for Drosophila Slit processing and for tendon-mediated muscle patterning
    Elly Ordan, Talila Volk
    Biology Open 2016 5: 1530-1534; doi: 10.1242/bio.020636

    Summary: The Drosophila homolog of pheromone convertase 2 (PC2), amontillado (Amon), is shown to contribute to Slit processing and further cleavage into an N-Slit, essential for Slit activity in directing muscle patterning.

  • Open Access
    Strategies used by two apterous strains of the pea aphid Acyrthosiphon pisum for passive dispersal
    Yi Zhang, Xing-Xing Wang, Jing-Yun Zhu, Zhan-Feng Zhang, Hong-Gang Tian, Tong-Xian Liu
    Biology Open 2016 5: 1535-1544; doi: 10.1242/bio.018903

    Summary: Two strains of pea aphid (Acyrthosiphon pisum) show different dispersal strategies, glycogen level and probing behaviors. One strain [Yangling strain (YL)] moves longer and disperses wider than another strain [Lanzhou (LZ)] based on higher glycogen. LZ strain probed more frequently, and identified plant more accurately than YL strain.

  • Open Access
    Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease
    Linqiang Zhang, Xiaoyun Wu, Shasha Liao, Yunhai Li, Zhiguo Zhang, Qing Chang, Ruyue Xiao, Bin Liang
    Biology Open 2016 5: 1545-1552; doi: 10.1242/bio.020875

    Summary: This study suggests that the tree shrew (Tupaia belangeri chinensis) may be useful as a novel animal model for the research of human non-obese non-alcoholic fatty liver disease (NAFLD).

CORRECTION

  • Open Access
    A novel method to study contact inhibition of locomotion using micropatterned substrates
    Elena Scarpa, Alice Roycroft, Eric Theveneau, Emmanuel Terriac, Matthieu Piel, Roberto Mayor
    Biology Open 2016 5: 1553 doi: 10.1242/bio.020917
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    Integrated Analysis of Cell Shape and Movement in Moving Frame

    Yusri Dwi Heryanto, Chin-Yi Cheng, Yutaka Uchida, Kazushi Mimura, Masaru Ishii, Ryo Yamada
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  • Open Access

    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
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  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
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    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
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    The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)

    Kun Guo, Jun Zhong, Lin Zhu, Fan Xie, Yu Du, Xiang Ji
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