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  You have access

  Open access

March, 2016; 5 (3)

RESEARCH ARTICLES

  • Open Access
    The effects of laboratory housing and spatial enrichment on brain size and metabolic rate in the eastern mosquitofish, Gambusia holbrooki
    Mischa P. Turschwell, Craig R. White
    Biology Open 2016 5: 205-210; doi: 10.1242/bio.015024

    Summary: The discovery of a difference in brain size between adult mosquitofish living in the wild, in spatially enriched tanks and in bare tanks has implications for the effect of environmental enrichment on transferability of data from laboratory animals to their wild counterparts.

  • Open Access
    Protective role of microRNA-29a in denatured dermis and skin fibroblast cells after thermal injury
    Jie Zhou, Xipeng Zhang, Pengfei Liang, Licheng Ren, Jizhang Zeng, Minghua Zhang, Pihong Zhang, Xiaoyuan Huang
    Biology Open 2016 5: 211-219; doi: 10.1242/bio.014910

    Summary: Inhibition of miR-29a can promote the proliferation and migration of skin fibroblast cells after thermal injury, and upregulate the production of COL1A2 and VEGF-A to further enhance the collagen synthesis and angiogenesis in skin and help burn wound healing in the later phase.

  • Open Access
    Thermal biology of the sub-polar–temperate estuarine crab Hemigrapsus crenulatus (Crustacea: Decapoda: Varunidae)
    Juan P. Cumillaf, Johnny Blanc, Kurt Paschke, Paulina Gebauer, Fernando Díaz, Denisse Re, María E. Chimal, Jorge Vásquez, Carlos Rosas
    Biology Open 2016 5: 220-228; doi: 10.1242/bio.013516

    Summary: The preferred temperature of the intertidal temperate crab Hemigrapsus crenulatus was determined to be between 12°C and 25°C. Oceanic warming would trap this species between tropical and polar temperatures, causing increasing population stress with unknown ecological consequences.

  • Open Access
    Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms
    Katherine A. Sharp, Jeffrey D. Axelrod
    Biology Open 2016 5: 229-236; doi: 10.1242/bio.016162

    Summary: Learning how Pk and Sple differentially interpret directional cues allows a broader understanding of the varied signals and mechanisms linking the core module to tissue axes in planar cell polarity.

  • Open Access
    Cdk4 functions in multiple cell types to control Drosophila intestinal stem cell proliferation and differentiation
    Mojca Adlesic, Christian Frei, Ian J. Frew
    Biology Open 2016 5: 237-251; doi: 10.1242/bio.016584

    Summary: We identify that the growth status of absorptive enterocyte cells in the Drosophila intestine controls the proliferation and differentiation of stem and progenitor cells, thereby controlling organ homeostasis.

  • Open Access
    The plant hopper Issus coleoptratus can detoxify phloem sap saponins including the degradation of the terpene core
    Markus Himmelsbach, Agnes Weth, Christine Böhme, Martin Schwarz, Peter Bräunig, Werner Baumgartner
    Biology Open 2016 5: 252-255; doi: 10.1242/bio.016311

    Summary: In contrast to other insects the plant hopper Issus coleoptratus does not accumulate toxic saponins from ivy. I. coleoptratus can degrade the saponines by its salivary glands and its gut as shown by HPLC-MS.

  • Open Access
    Phylogenetic analysis and tissue distribution of elasmobranch glucose transporters and their response to feeding
    Courtney A. Deck, Christophe M. R. LeMoine, Patrick J. Walsh
    Biology Open 2016 5: 256-261; doi: 10.1242/bio.016709

    Summary: Our results indicate the presence of three putative glucose transporters in elasmobranchs (GLUT1, 3, 4) and holocephalans (GLUT1, 2, 3). We determined that GLUT1 and GLUT4 mRNA levels change in various dogfish tissues in response to feeding.

  • Open Access
    Dive characteristics can predict foraging success in Australian fur seals (Arctocephalus pusillus doriferus) as validated by animal-borne video
    Beth L. Volpov, David A. S. Rosen, Andrew J. Hoskins, Holly J. Lourie, Nicole Dorville, Alastair M. M. Baylis, Kathryn E. Wheatley, Greg Marshall, Kyler Abernathy, Jayson Semmens, Mark A. Hindell, John P. Y. Arnould
    Biology Open 2016 5: 262-271; doi: 10.1242/bio.016659

    Summary: We assessed the ability of dive characteristics in Australian fur seals to predict foraging behavior and success that were directly observed on video. TDR data was able to reliably predict presence of prey as well as total successful prey captured per dive.

  • Open Access
    Does migratory distance affect fuelling in a medium-distance passerine migrant?: results from direct and step-wise simulated magnetic displacements
    Mihaela Ilieva, Giuseppe Bianco, Susanne Åkesson
    Biology Open 2016 5: 272-278; doi: 10.1242/bio.014779

    Summary: Fuelling rate in migrating dunnocks, a predominantly diurnal migratory songbird is influenced by a manipulated magnetic field when the birds are magnetically displaced north, but not south, in autumn.

  • Open Access
    Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function
    Willemieke M. Kouwenhoven, Jesse V. Veenvliet, Johannes A. van Hooft, L. P. van der Heide, Marten P. Smidt
    Biology Open 2016 5: 279-288; doi: 10.1242/bio.015032

    Summary: Local molecular coding under the influence of En1 is essential for proper spatiotemporal expression of key factors involved in the maintenance and function of the isthmic organizer.

  • Open Access
    Changes in cell shape are correlated with metastatic potential in murine and human osteosarcomas
    Samanthe M. Lyons, Elaheh Alizadeh, Joshua Mannheimer, Katherine Schuamberg, Jordan Castle, Bryce Schroder, Philip Turk, Douglas Thamm, Ashok Prasad
    Biology Open 2016 5: 289-299; doi: 10.1242/bio.013409

    Summary: Human and murine invasive osteosarcoma cancer cell lines, developed by selection in vivo from a less invasive parental line, show distinguishable differences in shape from the parental line that fall into two categories: more mesenchymal or more amoeboid.

  • Open Access
    Co-expression networks in generation of induced pluripotent stem cells
    Sharan Paul, Lance Pflieger, Warunee Dansithong, Karla P. Figueroa, Fuying Gao, Giovanni Coppola, Stefan M. Pulst
    Biology Open 2016 5: 300-310; doi: 10.1242/bio.016402

    Summary: We developed a novel adenoviral iPSC reprogramming vector integrating Yamanaka's four factors in a single cassette, allowing for the identification of biologically relevant co-expression networks.

  • Open Access
    Gene array analysis of neural crest cells identifies transcription factors necessary for direct conversion of embryonic fibroblasts into neural crest cells
    Tsutomu Motohashi, Natsuki Watanabe, Masahiro Nishioka, Yuhki Nakatake, Piao Yulan, Hiromi Mochizuki, Yoshifumi Kawamura, Minoru S. H. Ko, Naoki Goshima, Takahiro Kunisada
    Biology Open 2016 5: 311-322; doi: 10.1242/bio.015735

    Summary: In this study, we identified the transcription factors specifically expressed in developing neural crest cells, and showed that SOX10 and SOX9 directly converted fibroblasts into neural crest cells.

  • Open Access
    Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects
    Brian C. Gibbs, Rama Rao Damerla, Eszter K. Vladar, Bishwanath Chatterjee, Yong Wan, Xiaoqin Liu, Cheng Cui, George C. Gabriel, Maliha Zahid, Hisato Yagi, Heather L. Szabo-Rogers, Kaye L. Suyama, Jeffrey D. Axelrod, Cecilia W. Lo
    Biology Open 2016 5: 323-335; doi: 10.1242/bio.015750

    Summary: Outflow tract malalignment and multiple birth defects observed in the Prickle1 mutant may arise from cell polarity perturbation, which may involve disruptions in Wnt signaling and of cilia function.

  • Open Access
    Regulation of differentiation flux by Notch signalling influences the number of dopaminergic neurons in the adult brain
    Niurka Trujillo-Paredes, Concepción Valencia, Gilda Guerrero-Flores, Dulce-María Arzate, José-Manuel Baizabal, Magdalena Guerra-Crespo, Ayari Fuentes-Hernández, Iván Zea-Armenta, Luis Covarrubias
    Biology Open 2016 5: 336-347; doi: 10.1242/bio.013383

    Summary: The early emergence of dopaminergic neurons under reduced Notch signalling results from a change in the differentiation flux that defines the final number of neurons produced.

  • Open Access
    Analysis of coelom development in the sea urchin Holopneustes purpurescens yielding a deuterostome body plan
    Valerie B. Morris
    Biology Open 2016 5: 348-358; doi: 10.1242/bio.015925

    Summary: A common body plan for echinoderms, chordates and hemichordates resolves the apparent morphological disparity between the pentameral and the bilateral body plans of these major deuterostome phyla.

  • Open Access
    Genetic basis of hindlimb loss in a naturally occurring vertebrate model
    Emily K. Don, Tanya A. de Jong-Curtain, Karen Doggett, Thomas E. Hall, Benjamin Heng, Andrew P. Badrock, Claire Winnick, Garth A. Nicholson, Gilles J. Guillemin, Peter D. Currie, Daniel Hesselson, Joan K. Heath, Nicholas J. Cole
    Biology Open 2016 5: 359-366; doi: 10.1242/bio.016295

    Summary: Here we genetically characterise mutations in tbx4 which underlie pelvic finless, a naturally occurring model of hindlimb loss in zebrafish that lacks pelvic fin structures.

  • Open Access
    miR-22 inhibits mouse ovarian granulosa cell apoptosis by targeting SIRT1
    Fang Xiong, Lingqing Hu, Yun Zhang, Xiao Xiao, Juxia Xiao
    Biology Open 2016 5: 367-371; doi: 10.1242/bio.016907

    Summary: Overexpression of miR-22 inhibits mGC apoptosis by targeting SIRT1, and knockdown of SIRT1 attenuated apoptosis in mGCs. Taken together, these findings provide an improved understanding of the molecular mechanisms of miR-22-mediated follicular development.

  • Open Access
    Photobleaching studies reveal that a single amino acid polymorphism is responsible for the differential binding affinities of linker histone subtypes H1.1 and H1.5
    Thomas W. Flanagan, Jacob K. Files, Kelsey Rose Casano, Eric M. George, David T. Brown
    Biology Open 2016 5: 372-380; doi: 10.1242/bio.016733

    Summary: Mouse linker histone subtypes H1.1 and H1.5 bind to chromatin with different affinities due to a single amino acid polymorphism. Overexpression of H1.1 in fibroblasts accelerates cell cycle progression.

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    Integrated Analysis of Cell Shape and Movement in Moving Frame

    Yusri Dwi Heryanto, Chin-Yi Cheng, Yutaka Uchida, Kazushi Mimura, Masaru Ishii, Ryo Yamada
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  • Open Access

    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
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  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
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    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
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    The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)

    Kun Guo, Jun Zhong, Lin Zhu, Fan Xie, Yu Du, Xiang Ji
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