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  You have access

  Open access

April, 2016; 5 (4)

RESEARCH ARTICLES

  • Open Access
    The neurotoxic effects of hydrogen peroxide and copper in Retzius nerve cells of the leech Haemopis sanguisuga
    Zorica D. Jovanovic, Marija B. Stanojevic, Vladimir B. Nedeljkov
    Biology Open 2016 5: 381-388; doi: 10.1242/bio.014936

    Summary: This characterization of the early changes in physiological membrane properties of Retzius neurons provides evidence for the oxidative modification of outward potassium channels.

  • Open Access
    Preparation, anti-biofouling and drag-reduction properties of a biomimetic shark skin surface
    Xia Pu, Guangji Li, Hanlu Huang
    Biology Open 2016 5: 389-396; doi: 10.1242/bio.016899

    Summary: Specific microstructures of the shark skin surface have certain effects on surface wettability, and play a key role in reducing drag and anti-biofouling properties.

  • Open Access
    Planar cell polarity: the Dachsous/Fat system contributes differently to the embryonic and larval stages of Drosophila
    Pedro Saavedra, Amy Brittle, Isabel M. Palacios, David Strutt, José Casal, Peter A. Lawrence
    Biology Open 2016 5: 397-408; doi: 10.1242/bio.017152

    Summary: Drosophila utilises the Ds/Ft system differently as it develops. Localised expression of four-jointed in the tendon cells may help polarise all rows of denticles in late larval stages.

  • Open Access
    Cross-species functional analyses reveal shared and separate roles for Sox11 in frog primary neurogenesis and mouse cortical neuronal differentiation
    Chao Chen, Jing Jin, Garrett A. Lee, Elena Silva, Maria Donoghue
    Biology Open 2016 5: 409-417; doi: 10.1242/bio.015404

    Summary: Sox11 acts to designate neurons in both mouse and frog brains, but orthologs are not functionally redundant. These data show evolutionary conservation of Sox11 function with molecular divergence.

  • Open Access
    Establishment and evaluation of a transgenic mouse model of arthritis induced by overexpressing human tumor necrosis factor alpha
    Ge Li, Yu'e Wu, Huanhuan Jia, Lu Tang, Ren Huang, Yucai Peng, Yu Zhang
    Biology Open 2016 5: 418-423; doi: 10.1242/bio.016279

    Summary: We describe the establishment of a human TNFα transgenic arthritis mouse model with applications for understanding the role of TNFα in disease progression and developing therapeutic strategies.

  • Open Access
    The carboxyl terminal mutational hotspot of the ciliary disease protein RPGRORF15 (retinitis pigmentosa GTPase regulator) is glutamylated in vivo
    Kollu N. Rao, Manisha Anand, Hemant Khanna
    Biology Open 2016 5: 424-428; doi: 10.1242/bio.016816

    Summary: This study shows that the mutational hotspot of ciliary protein RPGRORF15, commonly associated with severe blindness, is posttranslationally glutamylated at its C-terminus and is a target of GT335.

  • Open Access
    Sortilin is associated with the chlamydial inclusion and is modulated during infection
    Wei Xuan Teo, Markus Charles Kerr, Wilhelmina May Huston, Rohan David Teasdale
    Biology Open 2016 5: 429-435; doi: 10.1242/bio.016485

    Summary: The acid sphingomyelinase trafficking protein sortilin is modulated by chlamydial infection. RNAi-mediated depletion of sortilin does not, however, perturb chlamydial infection.

  • Open Access
    Estimating energetics in cetaceans from respiratory frequency: why we need to understand physiology
    A. Fahlman, J. van der Hoop, M. J. Moore, G. Levine, J. Rocho-Levine, M. Brodsky
    Biology Open 2016 5: 436-442; doi: 10.1242/bio.017251

    Summary: Accounting for changes in tidal volume and gas exchange improves the ability to estimate field metabolic rate from respiratory frequency in cetaceans.

  • Open Access
    Post-hatching development of mitochondrial function, organ mass and metabolic rate in two ectotherms, the American alligator (Alligator mississippiensis) and the common snapping turtle (Chelydra serpentina)
    Sarah K. G. Sirsat, Tushar S. Sirsat, Edwin R. Price, Edward M. Dzialowski
    Biology Open 2016 5: 443-451; doi: 10.1242/bio.017160

    Summary: Unlike endothermic species, there is little change in skeletal and cardiac muscle mitochondrial function from the embryonic stage through the first year of life in ectothermic alligators and snapping turtles.

  • Open Access
    Dlc1 interaction with non-muscle myosin heavy chain II-A (Myh9) and Rac1 activation
    Mohammad G. Sabbir, Rachelle Dillon, Michael R. A. Mowat
    Biology Open 2016 5: 452-460; doi: 10.1242/bio.015859

    Summary: Dlc1 interacts with several actin filament-associated proteins including Myh9, spectrin and plectin. Transient overexpression of Dlc1 induces an elongated phenotype with elevated Rac1 activation.

  • Open Access
    A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex
    Johanna Andrae, Leonor Gouveia, Radiosa Gallini, Liqun He, Linda Fredriksson, Ingrid Nilsson, Bengt R. Johansson, Ulf Eriksson, Christer Betsholtz
    Biology Open 2016 5: 461-474; doi: 10.1242/bio.017368

    Summary: Developmental expression of Pdgfc and Pdgfra is necessary for the development of meninges and the glia limitans basement membrane. Failure of these processes leads to neuronal over-migration.

  • Open Access
    Impact of bronchopulmonary dysplasia on brain and retina
    Annie Wing Hoi Poon, Emilie Xiao Hang Ma, Arul Vadivel, Suna Jung, Zehra Khoja, Laurel Stephens, Bernard Thébaud, Pia Wintermark
    Biology Open 2016 5: 475-483; doi: 10.1242/bio.017665

    Summary: Our results suggest that the same animal model of chronic neonatal hyperoxia can be used to simultaneously study lung, brain and retinal injuries related to hyperoxia.

  • Open Access
    Exosomes from high glucose-treated glomerular endothelial cells activate mesangial cells to promote renal fibrosis
    Xiao-ming Wu, Yan-bin Gao, Fang-qiang Cui, Na Zhang
    Biology Open 2016 5: 484-491; doi: 10.1242/bio.015990

    Summary: In this study, we demonstrate that TGF-β1-containing exosomes from high glucose-treated glomerular endothelial cells can activate glomerular mesangial cells to promote renal fibrosis.

  • Open Access
    Knockdown of TC-1 enhances radiosensitivity of non-small cell lung cancer via the Wnt/β-catenin pathway
    Dapeng Wu, Lei Li, Wei Yan
    Biology Open 2016 5: 492-498; doi: 10.1242/bio.017608

    Summary: TC-1 silencing inhibited cell proliferation and induced apoptosis in non-small cell lung cancer (NSCLC) both in vitro and in vivo through the Wnt/β-catenin signaling pathway, thereby increasing the susceptibility of NSCLC to radiotherapy.

  • Open Access
    Association between tensin 1 and p130Cas at focal adhesions links actin inward flux to cell migration
    Zhihai Zhao, Song Hui Tan, Hiroaki Machiyama, Keiko Kawauchi, Keigo Araki, Hiroaki Hirata, Yasuhiro Sawada
    Biology Open 2016 5: 499-506; doi: 10.1242/bio.016428

    Summary: Tensin 1 links phosphorylated Cas to actin inward flux, facilitating the force transmission from the motile system (i.e. actomyosin contraction) to the stationary parts (i.e. adhesion complexes) in migrating cells.

  • Open Access
    Response of garlic (Allium sativum L.) bolting and bulbing to temperature and photoperiod treatments
    Cuinan Wu, Mengyi Wang, Zhihui Cheng, Huanwen Meng
    Biology Open 2016 5: 507-518; doi: 10.1242/bio.016444

    Summary: We show that a higher temperature and longer photoperiod are essential for garlic bolting and bulbing. Varied endogenous phytohormone and MeJA levels might lead to the different responses of the studied cultivars to treatments.

  • Open Access
    Biosafety of biotechnologically important microalgae: intrinsic suicide switch implementation in cyanobacterium Synechocystis sp. PCC 6803
    Helena Čelešnik, Anja Tanšek, Aneja Tahirović, Angelika Vižintin, Jernej Mustar, Vita Vidmar, Marko Dolinar
    Biology Open 2016 5: 519-528; doi: 10.1242/bio.017129

    Summary: Biosafety of biotechnologically important microalgae was addressed by suicide switch implementation in cyanobacterium Synechocystis sp. PCC 6803. This is the first report of biocontainment safeguards in cyanobacteria.

METHODS & TECHNIQUES

  • Open Access
    NGT-3D: a simple nematode cultivation system to study Caenorhabditis elegans biology in 3D
    Tong Young Lee, Kyoung-hye Yoon, Jin Il Lee
    Biology Open 2016 5: 529-534; doi: 10.1242/bio.015743

    Summary: We have designed a three dimensional nematode habitat for use in the lab, called NGT-3D, where growth, fertility and lifespan are comparable with the traditional two dimensional lab environment.

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  • Open Access

    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
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  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
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  • Open Access

    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
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    Conditional targeting of phosphatidylserine decarboxylase to lipid droplets

    Santosh Kumar, Chandramohan Chitraju, Robert Farese, Tobias Walther, Christopher G. Burd
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    The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)

    Kun Guo, Jun Zhong, Lin Zhu, Fan Xie, Yu Du, Xiang Ji
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