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  You have access

  Open access

May, 2016; 5 (5)

CORRESPONDENCE

  • Open Access
    Sun proteins and Dpy19l2 forming LINC-like links are critical for spermiogenesis
    Pierre F. Ray, Charles Coutton, Christophe Arnoult
    Biology Open 2016 5: 535-536; doi: 10.1242/bio.016626

    Summary: In this response to Pasch et al.’s (2015) discovery that Sun4 is essential for sperm head formation, the authors highlight that like Sun4, Dpy19l2 has a likely LINK-like function and that it also plays a crucial role in spermiogenesis and male infertility.

RESEARCH ARTICLES

  • Open Access
    C. elegans flavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress
    Nisha Hirani, Marcel Westenberg, Paul T. Seed, Mark I. R. Petalcorin, Colin T. Dolphin
    Biology Open 2016 5: 537-549; doi: 10.1242/bio.017400

    Summary: C. elegans lacking fmo-4 fail to clear body water following hypotonic exposure resulting in rapid swelling and rupture, indicating that FMO-4 is required in the hypoosmotic stress response.

  • Open Access
    Feliform carnivores have a distinguished constitutive innate immune response
    Sonja K. Heinrich, Bettina Wachter, Ortwin H. K. Aschenborn, Susanne Thalwitzer, Jörg Melzheimer, Heribert Hofer, Gábor Á. Czirják
    Biology Open 2016 5: 550-555; doi: 10.1242/bio.014902

    Summary: The innate immunocompetence of six free-ranging carnivores is independent of their foraging behaviour, body mass or social organisation but reflects their phylogenetic relatedness.

  • Open Access
    Training differentially regulates elastin level and proteolysis in skeletal and heart muscles and aorta in healthy rats
    Anna Gilbert, Aleksandra Wyczalkowska-Tomasik, Malgorzata Zendzian-Piotrowska, Bozena Czarkowska-Paczek
    Biology Open 2016 5: 556-562; doi: 10.1242/bio.017459

    Summary: Endurance training increases elastin content in muscles but not in the aorta. The activities of enzymes responsible for ECM remodeling increase only in skeletal muscle. These changes seem to be adaptive.

  • Open Access
    MicroRNA-204 modulates colorectal cancer cell sensitivity in response to 5-fluorouracil-based treatment by targeting high mobility group protein A2
    Haijun Wu, Yu Liang, Lin Shen, Liangfang Shen
    Biology Open 2016 5: 563-570; doi: 10.1242/bio.015008

    Summary: miR-204 upregulates 5-Fu chemosensitivity via the downregulation of HMGA2 in colorectal cancer and provides significant insight into the mechanism of 5-Fu resistance in colorectal cancer patients.

  • Open Access
    VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis
    Gareth W. Fearnley, Gina A. Smith, Izma Abdul-Zani, Nadira Yuldasheva, Nadeem A. Mughal, Shervanthi Homer-Vanniasinkam, Mark T. Kearney, Ian C. Zachary, Darren C. Tomlinson, Michael A. Harrison, Stephen B. Wheatcroft, Sreenivasan Ponnambalam
    Biology Open 2016 5: 571-583; doi: 10.1242/bio.017434

    Summary: We show that vascular endothelial growth factor (VEGF-A) isoforms program differential tyrosine phosphorylation, ubiquitylation, endocytosis and proteolysis of the receptor tyrosine kinase, VEGFR2.

  • Open Access
    Trim37-deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism
    Kaisa M. Kettunen, Riitta Karikoski, Riikka H. Hämäläinen, Teija T. Toivonen, Vasily D. Antonenkov, Natalia Kulesskaya, Vootele Voikar, Maarit Hölttä-Vuori, Elina Ikonen, Kirsi Sainio, Anu Jalanko, Susann Karlberg, Niklas Karlberg, Marita Lipsanen-Nyman, Jorma Toppari, Matti Jauhiainen, J. Kalervo Hiltunen, Hannu Jalanko, Anna-Elina Lehesjoki
    Biology Open 2016 5: 584-595; doi: 10.1242/bio.016246

    Summary: A congenic Trim37-deficient mouse model recapitulates several features of the human disorder Mulibrey nanism, and thus provides a good model to study disease pathogenesis related to TRIM37 deficiency.

  • Open Access
    Survival of glucose phosphate isomerase null somatic cells and germ cells in adult mouse chimaeras
    Margaret A. Keighren, Jean H. Flockhart, John D. West
    Biology Open 2016 5: 596-610; doi: 10.1242/bio.017111

    Summary: Some Gpi1−/− somatic cells, lacking the glycolytic enzyme GPI, survived in mouse chimaeras. Breeding experiments showed that some GPI-null oocytes and spermatozoa were viable and functional.

  • Open Access
    Olfactory organ of Octopus vulgaris: morphology, plasticity, turnover and sensory characterization
    Gianluca Polese, Carla Bertapelle, Anna Di Cosmo
    Biology Open 2016 5: 611-619; doi: 10.1242/bio.017764

    Summary: A 3D reconstruction of the Octopus vulgaris olfactory organ, as well as the localization of PCNA and (for the first time) OMP-like proteins in cephalopod mature olfactory chemosensory neurons are described.

  • Open Access
    CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis
    Kanin Salao, Lele Jiang, Hui Li, Vicky W.-W. Tsai, Yasmin Husaini, Paul M. G. Curmi, Louise J. Brown, David A. Brown, Samuel N. Breit
    Biology Open 2016 5: 620-630; doi: 10.1242/bio.018119

    Summary: DC phagosomes from CLIC1−/− mice display impaired acidification and in vivo and in vitro antigen processing and presentation, revealing CLIC1−/− as a potential therapeutic target in reducing the adaptive immune response in autoimmune diseases.

  • Open Access
    Garlic exerts allelopathic effects on pepper physiology in a hydroponic co-culture system
    Haiyan Ding, Zhihui Cheng, Menglong Liu, Sikandar Hayat, Han Feng
    Biology Open 2016 5: 631-637; doi: 10.1242/bio.016451

    Summary: Garlic exerts allelopathic effects on pepper physiology in a hydroponic co-culture system, with low concentrations of garlic root promoting pepper growth, but high concentrations having deleterious effects.

  • Open Access
    Simultaneous optimisation of earwig hindwings for flight and folding
    Julia Deiters, Wojciech Kowalczyk, Tobias Seidl
    Biology Open 2016 5: 638-644; doi: 10.1242/bio.016527

    Summary: Adjustments of the wing structure in earwig hindwings enable passive wing control during flapping flight. With an expansion of the claval flexion line, the highly foldable wing can withstand deformations during flapping flight and stay unfolded.

  • Open Access
    PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL
    Brandi L. Carofino, Bernard Ayanga, Lauren J. Tracey, Travis Brooke-Bisschop, Monica J. Justice
    Biology Open 2016 5: 645-653; doi: 10.1242/bio.017699

    Summary: PRDM14 promotes an epigenetic state that facilitates RAG-dependent Notch1 driver mutations, coupling progenitor cell expansion with genomic instability to produce T-ALL with shorter latency than other NOTCH1-driven mouse models.

  • Open Access
    Time-resolved functional analysis of acute impairment of frataxin expression in an inducible cell model of Friedreich ataxia
    Dörte Poburski, Josefine Barbara Boerner, Michel Koenig, Michael Ristow, René Thierbach
    Biology Open 2016 5: 654-661; doi: 10.1242/bio.017004

    Summary: The use of a new mammalian cell model with inducible homozygous and heterozygous frataxin knockout allows new insights into the chronology and causes of the disease Friedreich ataxia.

METHODS & TECHNIQUES

  • Open Access
    Functional characterisation of human synaptic genes expressed in the Drosophila brain
    Lysimachos Zografos, Joanne Tang, Franziska Hesse, Erich E. Wanker, Ka Wan Li, August B. Smit, R. Wayne Davies, J. Douglas Armstrong
    Biology Open 2016 5: 662-667; doi: 10.1242/bio.016261

    Summary: This report describes a resource collection of Drosophila melanogaster strains expressing human synaptic genes and methods that can be applied in order to investigate the genes' function.

CORRECTION

  • Open Access
    C. elegans flavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress
    Nisha Hirani, Marcel Westenberg, Paul T. Seed, Mark I. R. Petalcorin, Colin T. Dolphin
    Biology Open 2016 5: 668 doi: 10.1242/bio.019166
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    Integrated Analysis of Cell Shape and Movement in Moving Frame

    Yusri Dwi Heryanto, Chin-Yi Cheng, Yutaka Uchida, Kazushi Mimura, Masaru Ishii, Ryo Yamada
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  • Open Access

    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
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  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
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    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
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    The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)

    Kun Guo, Jun Zhong, Lin Zhu, Fan Xie, Yu Du, Xiang Ji
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