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  You have access

  Open access

August, 2016; 5 (8)

RESEARCH ARTICLES

  • Open Access
    B-type nuclear lamin and the nuclear pore complex Nup107-160 influences maintenance of the spindle envelope required for cytokinesis in Drosophila male meiosis
    Daisuke Hayashi, Karin Tanabe, Hiroka Katsube, Yoshihiro H. Inoue
    Biology Open 2016 5: 1011-1021; doi: 10.1242/bio.017566

    Summary: B-type lamin, positioned by nuclear pore component Nup107, strengthens the membranous intracellular structure supporting the microtubule bundles essential for cytokinesis in Drosophila male meiosis.

  • Open Access
    Plasmodium AdoMetDC/ODC bifunctional enzyme is essential for male sexual stage development and mosquito transmission
    Robert J. Hart, Atif Ghaffar, Shaymaa Abdalal, Benjamin Perrin, Ahmed S. I. Aly
    Biology Open 2016 5: 1022-1029; doi: 10.1242/bio.016352

    Summary: We provide the first genetic evidence for the crucial roles of de novo polyamine biosynthesis in the development of Plasmodium male sexual stages and in the transmission of malaria parasite to mosquito.

  • Open Access
    AβPP processing results in greater toxicity per amount of Aβ1-42 than individually expressed and secreted Aβ1-42 in Drosophila melanogaster
    Liza Bergkvist, Linnea Sandin, Katarina Kågedal, Ann-Christin Brorsson
    Biology Open 2016 5: 1030-1039; doi: 10.1242/bio.017194

    Summary: In Drosophila, the proteotoxic effect of Aβ1-42 is highly dependent on how and where the peptide is generated, rather than on the peptide level in the flies, with implications for Alzheimer's disease research.

  • Open Access
    Loss of function of the Drosophila Ninein-related centrosomal protein Bsg25D causes mitotic defects and impairs embryonic development
    Michelle Kowanda, Julie Bergalet, Michal Wieczorek, Gary Brouhard, Éric Lécuyer, Paul Lasko
    Biology Open 2016 5: 1040-1051; doi: 10.1242/bio.019638

    Summary: In humans, mutations in Ninein or Ninein-like protein result in microcephaly and other severe diseases. We show that while flies lacking the Ninein orthologue can survive, many die as embryos with defects in mitosis.

  • Open Access
    Outperforming hummingbirds’ load-lifting capability with a lightweight hummingbird-like flapping-wing mechanism
    Frederik Leys, Dominiek Reynaerts, Dirk Vandepitte
    Biology Open 2016 5: 1052-1060; doi: 10.1242/bio.014357

    Summary: The stroke-cam flapping mechanism closely mimics the wing motion of a hummingbird. It is the only lightweight hummingbird-sized flapping mechanism which generates a harmonic wing stroke with both a high flapping frequency and a large stroke amplitude.

  • Open Access
    Two types of dominant male cichlid fish: behavioral and hormonal characteristics
    Rosa M. Alcazar, Lisa Becker, Austin T. Hilliard, Kai R. Kent, Russell D. Fernald
    Biology Open 2016 5: 1061-1071; doi: 10.1242/bio.017640

    Summary: We discover a subclass of dominant male in A. burtoni with escalating aggression that displays distinct behavioral and endocrine profiles, which may serve as a model to investigate maladaptive aggressive behavior.

  • Open Access
    Quasi-steady state aerodynamics of the cheetah tail
    Amir Patel, Edward Boje, Callen Fisher, Leeann Louis, Emily Lane
    Biology Open 2016 5: 1072-1076; doi: 10.1242/bio.018457

    Summary: The aerodynamics of the cheetah tail are non-trivial. This paper is the first to quantify the effect of aerodynamic forces from a cheetah's tail during rapid manoeuvres.

  • Open Access
    Gait in ducks (Anas platyrhynchos) and chickens (Gallus gallus) – similarities in adaptation to high growth rate
    B. M. Duggan, P. M. Hocking, D. N. Clements
    Biology Open 2016 5: 1077-1085; doi: 10.1242/bio.018614

    Summary: Different bird species bred for meat production have adapted their gait in similar ways to handle the extra loads imposed on their legs by larger muscle masses.

  • Open Access
    Probing extracellular Sonic hedgehog in neurons
    Erez Eitan, Ronald S. Petralia, Ya-Xian Wang, Fred E. Indig, Mark P. Mattson, Pamela J. Yao
    Biology Open 2016 5: 1086-1092; doi: 10.1242/bio.019422

    Summary: In the developing brain, Sonic hedgehog molecules localize in neuronal filopodia and preferentially position at cell-to-cell contacts. In cultured neurons, Sonic hedgehog is also found in extracellular vesicles.

  • Open Access
    Hypersalinity drives physiological and morphological changes in Limia perugiae (Poeciliidae)
    Pablo F. Weaver, Oscar Tello, Jonathan Krieger, Arlen Marmolejo, Kathleen F. Weaver, Jerome V. Garcia, Alexander Cruz
    Biology Open 2016 5: 1093-1101; doi: 10.1242/bio.017277

    Summary: A population of Limia perugiae living in hypersalinity shows modifications to osmoregulatory mechanisms, correlated with changes to body size, morphology of the head, and secondary sex features.

  • Open Access
    The role of acroblast formation during Drosophila spermatogenesis
    Karolina Fári, Sándor Takács, Dániel Ungár, Rita Sinka
    Biology Open 2016 5: 1102-1110; doi: 10.1242/bio.018275

    Summary: This study demonstrates that retrograde tethering complexes are necessary to form a functional acroblast, which is essential for normal nuclear elongation and acrosome formation during Drosophila spermatogenesis.

  • Open Access
    A locus in Pristionchus pacificus that is responsible for the ability to give rise to fertile offspring at higher temperatures
    Mark Leaver, Simone Kienle, Maria L. Begasse, Ralf J. Sommer, Anthony A. Hyman
    Biology Open 2016 5: 1111-1117; doi: 10.1242/bio.018127

    Summary: Here we describe a phenotype in Pristionchus pacificus responsible for increased fitness at higher temperatures, and present mapping of a locus responsible for this ability in two natural isolates.

  • Open Access
    An in vitro model of granuloma-like cell aggregates substantiates early host immune responses against Mycobacterium massiliense infection
    Sungmo Je, Hailian Quan, Yirang Na, Sang-Nae Cho, Bum-Joon Kim, Seung Hyeok Seok
    Biology Open 2016 5: 1118-1127; doi: 10.1242/bio.019315

    Summary: An in vitro model of granuloma-like cell aggregates infected with Mycobacterium massiliense improves our understanding of the interplay of host immune cells with mycobacteria.

  • Open Access
    Alcohol exposure leads to unrecoverable cardiovascular defects along with edema and motor function changes in developing zebrafish larvae
    Xu Li, Aiai Gao, Yanan Wang, Man Chen, Jun Peng, Huaying Yan, Xin Zhao, Xizeng Feng, Dongyan Chen
    Biology Open 2016 5: 1128-1133; doi: 10.1242/bio.019497

    Summary: Alcohol exposure causes cardiovascular defects along with edema and motor function changes in zebrafish larvae that are unrecoverable in the post-exposure period.

  • Open Access
    Cortisol-treated zebrafish embryos develop into pro-inflammatory adults with aberrant immune gene regulation
    Ellen I. Hartig, Shusen Zhu, Benjamin L. King, James A. Coffman
    Biology Open 2016 5: 1134-1141; doi: 10.1242/bio.020065

    Summary: Chronically elevated glucocorticoid stress signaling during early zebrafish development has long-term consequences that affect immune gene expression and regulation in adulthood.

METHODS & TECHNIQUES

  • Open Access
    Ultra-superovulation for the CRISPR-Cas9-mediated production of gene-knockout, single-amino-acid-substituted, and floxed mice
    Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Noriyuki Yanaka, Toru Takeo, Naomi Nakagata, Takashi Yamamoto
    Biology Open 2016 5: 1142-1148; doi: 10.1242/bio.019349

    Summary: We demonstrate the production of CRISPR-Cas9-mediated knockout and knock-in mice using a recently developed ultra-superovulation technique to obtain greater numbers of oocytes compared with conventional methods.

  • Open Access
    Development of a diet-induced murine model of diabetes featuring cardinal metabolic and pathophysiological abnormalities of type 2 diabetes
    Jodie L. Morris, Tahnee L. Bridson, Md Abdul Alim, Catherine M. Rush, Donna M. Rudd, Brenda L. Govan, Natkunam Ketheesan
    Biology Open 2016 5: 1149-1162; doi: 10.1242/bio.016790

    Summary: We describe a murine model of type 2 diabetes based on chronic consumption of an energy-dense diet. Longitudinal sampling demonstrates metabolic and pathological changes closely simulating progression to overt diabetes.

  • Open Access
    Recovering signals in physiological systems with large datasets
    Hodjat Pendar, John J. Socha, Julianne Chung
    Biology Open 2016 5: 1163-1174; doi: 10.1242/bio.019133

    Summary: We introduce two methods to recover true physiological signals from indirectly measured data. As a demonstration, we show precise recovery of gas-exchange patterns from a grasshopper recorded in a flow-through respirometry system.

CORRECTION

  • Open Access
    The labial gene is required to terminate proliferation of identified neuroblasts in postembryonic development of the Drosophila brain
    Philipp A. Kuert, Bruno C. Bello, Heinrich Reichert
    Biology Open 2016 5: 1175 doi: 10.1242/bio.020230
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  • Open Access

    A modifier screen identifies regulators of cytoskeletal architecture as mediators of Shroom-dependent changes in tissue morphology

    Jeffrey D. Hildebrand, Adam D. Leventry, Omoregie P. Aideyman, John C. Majewski, James A. Haddad, Nancy Kaufmann
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  • Open Access

    Quantified growth of the human embryonic heart

    Jaeike W. Faber, Jaco Hagoort, Antoon F. M. Moorman, Vincent M. Christoffels, Bjarke Jensen
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  • Open Access

    Dissecting dynamics and differences of selective pressures in the evolution of human pigmentation

    Xin Huang, Sijia Wang, Li Jin, Yungang He
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  • Open Access

    Auxin confers protection against ER stress in Caenorhabditis elegans

    A. Bhoi, F. Palladino, P. Fabrizio
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  • Open Access

    Smoking flies: Testing the effect of tobacco cigarettes on heart function of Drosophila melanogaster

    Manuela Santalla, Lucía Pagola, Ivana Gómez, Darío Balcazar, Carlos A. Valverde, Paola Ferrero
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