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  You have access

  Open access

January, 2017; 6 (1)

RESEARCH ARTICLES

  • Open Access
    REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6
    Rohit Chavan, Nadia Preitner, Takashi Okabe, Laureen Mansencal Strittmatter, Cheng Xu, Jürgen A. Ripperger, Nelly Pitteloud, Urs Albrecht
    Biology Open 2017 6: 1-7; doi: 10.1242/bio.021519

    Summary: The hepatokine Fgf21 is transcriptionally regulated by the nuclear receptor REV-ERBα with the hepatocyte-specific factor HNF6 to regulate metabolism and fertility.

  • Open Access
    Involvement of BDNF/TrkB and ERK/CREB axes in nitroglycerin-induced rat migraine and effects of estrogen on these signals in the migraine
    Jiu-Qing Guo, Hui-Hui Deng, Xiao Bo, Xiao-Su Yang
    Biology Open 2017 6: 8-16; doi: 10.1242/bio.021022

    Summary: This study unveiled a positive correlation of BDNF/TrkB and CREB/ERK axes in NTG-induced migraine and the promoting effects of estrogen on their signals in the migraine.

  • Open Access
    Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos
    Jeffrey C. Medley, Megan M. Kabara, Michael D. Stubenvoll, Lauren E. DeMeyer, Mi Hye Song
    Biology Open 2017 6: 17-28; doi: 10.1242/bio.022418

    Summary: The conserved protein kinase CK2 negatively regulates centrosome assembly and is required for proper cell cycle progression and cytokinesis in early C. elegans embryos.

  • Open Access
    Knockdown of histidine-rich calcium-binding protein (HRC) suppresses liver fibrosis by inhibiting the activation of hepatic stellate cells
    Jingmei Liu, Mengke Li, Jin Gong, Ping Han, Yunwu Wang, Dongxiao Li, Dean Tian, Jiazhi Liao
    Biology Open 2017 6: 29-34; doi: 10.1242/bio.019828

    Summary: We provide the first evidence to confirm that HRC is a factor in liver fibrosis, and we clarify the molecular mechanism of HRC in hepatic stellate cell activation and liver fibrosis.

  • Open Access
    Ole1, fatty acid desaturase, is required for Atg9 delivery and isolation membrane expansion during autophagy in Saccharomyces cerevisiae
    Yuta Ogasawara, Shintaro Kira, Yukio Mukai, Takeshi Noda, Akitsugu Yamamoto
    Biology Open 2017 6: 35-40; doi: 10.1242/bio.022053

    Summary: Isolation membrane expansion in yeast autophagy requires mono-unsaturated fatty acids generated by Ole1, fatty acid desaturase during delivery of Atg9 to the PAS/autophagosome from its cellular reservoir.

  • Open Access
    Social signals and aversive learning in honey bee drones and workers
    Arian Avalos, Eddie Pérez, Lianna Vallejo, María E. Pérez, Charles I. Abramson, Tugrul Giray
    Biology Open 2017 6: 41-49; doi: 10.1242/bio.021543

    Summary: Alarms serve to focus attention and prioritize individual concerns. In honey bees, social alarm impairs appetitive learning. Here, we show that the effect on aversive learning depends on social role and signal intensity.

  • Open Access
    Chicken muscle mitochondrial content appears co-ordinately regulated and is associated with performance phenotypes
    Antonio Reverter, Ron Okimoto, Robyn Sapp, Walter G. Bottje, Rachel Hawken, Nicholas J. Hudson
    Biology Open 2017 6: 50-58; doi: 10.1242/bio.022772

    Summary: We have detected variation in muscle mitochondrial content across chickens. This variation relates to phenotypes and also indicates coordinate regulation of mitochondrial biogenesis across the musculature.

  • Open Access
    Gene silencing of Nox4 by CpG island methylation during hepatocarcinogenesis in rats
    Guadalupe S. López-Álvarez, Tomasz K. Wojdacz, Claudia M. García-Cuellar, Hugo C. Monroy-Ramírez, Miguel A. Rodríguez-Segura, Ruth A. Pacheco-Rivera, Carlos A. Valencia-Antúnez, Nancy Cervantes-Anaya, Ernesto Soto-Reyes, Verónica R. Vásquez-Garzón, Yesennia Sánchez-Pérez, Saúl Villa-Treviño
    Biology Open 2017 6: 59-70; doi: 10.1242/bio.020370

    Summary: Many genes downregulated by DNA methylation are tumor suppressor genes. In the present study, DNA methylation of Nox4 is observed, with implications for Nox4 as a potential therapeutic target for liver or other cancers.

  • Open Access
    Evidence toads may modulate landing preparation without predicting impact time
    S. M. Cox, Gary Gillis
    Biology Open 2017 6: 71-76; doi: 10.1242/bio.022707

    Summary: Coordination of landing in humans involves using sensory feedback to anticipate impact time. In contrast, when and how toads position forelimbs suggests that they may coordinate landing without predicting impact.

  • Open Access
    Daily feeding and protein metabolism rhythms in Senegalese sole post-larvae
    Carmen Navarro-Guillén, Manuel Yúfera, Sofia Engrola
    Biology Open 2017 6: 77-82; doi: 10.1242/bio.021642

    Summary: This manuscript provides new knowledge regarding Senegalese sole post-larvae daily feeding behavior and protein metabolism, which are essential for the adequate development of feeding strategies for this species.

  • Open Access
    Metabolism and antioxidant defense in the larval chironomid Tanytarsus minutipalpus: adjustments to diel variations in the extreme conditions of Lake Magadi
    Lucas F. Bianchini, Chris M. Wood, Harold L. Bergman, Ora E. Johannsson, Pierre Laurent, Claudine Chevalier, Mosiany L. Kisipan, Geraldine D. Kavembe, Michael B. Papah, Kevin V. Brix, Gudrun De Boeck, John N. Maina, Rodi O. Ojoo, Adalto Bianchini
    Biology Open 2017 6: 83-91; doi: 10.1242/bio.021139

    Summary: Insect larvae display adjustments in metabolism and oxidative status to overcome the diel variations in the extreme and harsh physicochemical conditions of Lake Magadi, a saline and alkaline lake in Kenya.

  • Open Access
    Cardiomyocyte­-specific expression of the nuclear matrix protein, CIZ1, stimulates production of mono-nucleated cells with an extended window of proliferation in the postnatal mouse heart
    Sumia A. Bageghni, Georgia A. Frentzou, Mark J. Drinkhill, William Mansfield, Dawn Coverley, Justin F. X. Ainscough
    Biology Open 2017 6: 92-99; doi: 10.1242/bio.021550

    Summary: An inducible mouse model was developed to show that CIZ1 extends the window of cardiomyocyte proliferation and reduces the impact of injury on cardiac function.

  • Open Access
    Systematic evaluation of markers used for the identification of human induced pluripotent stem cells
    Sumitha Prameela Bharathan, Kannan Vrindavan Manian, Syed Mohammed Musheer Aalam, Dhavapriya Palani, Prashant Ajit Deshpande, Mankuzhy Damodaran Pratheesh, Alok Srivastava, Shaji Ramachandran Velayudhan
    Biology Open 2017 6: 100-108; doi: 10.1242/bio.022111

    Summary: The use of hESC-like morphology, retroviral transgene silencing and temporal expression of pluripotency markers are compared as methods to aid in the identification of hiPSC clones.

  • Open Access
    The anti-bat strategy of ultrasound absorption: the wings of nocturnal moths (Bombycoidea: Saturniidae) absorb more ultrasound than the wings of diurnal moths (Chalcosiinae: Zygaenoidea: Zygaenidae)
    Athanasios Ntelezos, Francesco Guarato, James F. C. Windmill
    Biology Open 2017 6: 109-117; doi: 10.1242/bio.021782

    Summary: Moth wings partly absorb the ultrasonic calls of bats to reduce predation. Different moths fly at night or day, and this work compares their absorption of ultrasound.

  • Open Access
    Movement patterns of cheetahs (Acinonyx jubatus) in farmlands in Botswana
    L. K. Van der Weyde, T. Y. Hubel, J. Horgan, J. Shotton, R. McKenna, A. M. Wilson
    Biology Open 2017 6: 118-124; doi: 10.1242/bio.021055

    Summary: Cheetah movement patterns within farmlands revealed a preference for areas important for social interactions and avoidance of high risk areas. This knowledge can be useful for developing conflict mitigation strategies.

METHODS & TECHNIQUES

  • Open Access
    Utilising polymorphisms to achieve allele-specific genome editing in zebrafish
    Samuel J. Capon, Gregory J. Baillie, Neil I. Bower, Jason A. da Silva, Scott Paterson, Benjamin M. Hogan, Cas Simons, Kelly A. Smith
    Biology Open 2017 6: 125-131; doi: 10.1242/bio.020974

    Summary: Heterozygous single nucleotide polymorphisms in CRISPR/Cas9 target sites bias genome editing in favour of alleles with perfect complementarity to gRNAs, a feature which can be exploited for chromosome-specific editing.

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    A modifier screen identifies regulators of cytoskeletal architecture as mediators of Shroom-dependent changes in tissue morphology

    Jeffrey D. Hildebrand, Adam D. Leventry, Omoregie P. Aideyman, John C. Majewski, James A. Haddad, Nancy Kaufmann
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    Quantified growth of the human embryonic heart

    Jaeike W. Faber, Jaco Hagoort, Antoon F. M. Moorman, Vincent M. Christoffels, Bjarke Jensen
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    Dissecting dynamics and differences of selective pressures in the evolution of human pigmentation

    Xin Huang, Sijia Wang, Li Jin, Yungang He
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  • Open Access

    Auxin confers protection against ER stress in Caenorhabditis elegans

    A. Bhoi, F. Palladino, P. Fabrizio
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    Smoking flies: Testing the effect of tobacco cigarettes on heart function of Drosophila melanogaster

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