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  You have access

  Open access

October, 2017; 6 (10)

PUBLISHER'S NOTE

  • Open Access
    Patricia Keely (1963-2017)
    Jordan W. Raff
    Biology Open 2017 6: 1403 doi: 10.1242/bio.030098

RESEARCH ARTICLES

  • Open Access
    Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function
    Gina A. Smith, Gareth W. Fearnley, Izma Abdul-Zani, Stephen B. Wheatcroft, Darren C. Tomlinson, Michael A. Harrison, Sreenivasan Ponnambalam
    Biology Open 2017 6: 1404-1415; doi: 10.1242/bio.027896

    Summary: Ubiquitin-mediated modulation of membrane trafficking and turnover of an endothelial receptor tyrosine kinase (VEGFR2) thus regulates proteolysis, receptor activation, signal transduction and downstream cellular responses. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.

  • Open Access
    Blocking autophagy enhances the pro-apoptotic effect of bufalin on human gastric cancer cells through endoplasmic reticulum stress
    Hongyan Zhao, Qinghua Li, Jie Pang, Huilin Jin, Hongwei Li, Xiaoying Yang
    Biology Open 2017 6: 1416-1422; doi: 10.1242/bio.026344

    Summary: Bufalin suppressed human gastric cancer cells and induced apoptosis. The mechanism was related to ER stress formation via the IRE1-JNK pathway. Blocking autophagy exacerbated bufalin-induced apoptosis.

  • Open Access
    An immunofluorescence assay for extracellular matrix components highlights the role of epithelial cells in producing a stable, fibrillar extracellular matrix
    Omar S. Qureshi, Hélène Bon, Breda Twomey, Gill Holdsworth, Kirsty Ford, Marianne Bergin, Linghong Huang, Mariusz Muzylak, Louise J. Healy, Vanessa Hurdowar, Timothy S. Johnson
    Biology Open 2017 6: 1423-1433; doi: 10.1242/bio.025866

    Summary: Using an immunofluorescence extracellular matrix, we show that epithelial cells can deposit extracellular matrix components in a comparable manner to fibroblasts highlighting their role as potential targets in fibrotic disease.

  • Open Access
    An AMPK-dependent regulatory pathway in tau-mediated toxicity
    Alessia Galasso, Charles S. Cameron, Bruno G. Frenguelli, Kevin G. Moffat
    Biology Open 2017 6: 1434-1444; doi: 10.1242/bio.022863

    Summary: Dissection of the impact of AMPK and autophagy on tau-mediated toxicity by using an in vivo Drosophila tool as readout to perform preliminary drug screening supported by quantitative analyses.

  • Open Access
    HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner
    Vaibhav P. Pai, Valerie Willocq, Emily J. Pitcairn, Joan M. Lemire, Jean-François Paré, Nian-Qing Shi, Kelly A. McLaughlin, Michael Levin
    Biology Open 2017 6: 1445-1457; doi: 10.1242/bio.025957

    Summary: We identify a novel, developmental role for HCN4 channels and reveal a new Nodal-Lefty-Pitx2-independent, non-canonical mechanism upstream of organ positioning during embryonic left-right patterning. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.

  • Open Access
    SERCA directs cell migration and branching across species and germ layers
    Danielle V. Bower, Nick Lansdale, Sonia Navarro, Thai V. Truong, Dan J. Bower, Neil C. Featherstone, Marilyn G. Connell, Denise Al Alam, Mark R. Frey, Le A. Trinh, G. Esteban Fernandez, David Warburton, Scott E. Fraser, Daimark Bennett, Edwin C. Jesudason
    Biology Open 2017 6: 1458-1471; doi: 10.1242/bio.026039

    Summary: Dynamic imaging of living embryos demonstrates that SERCA is a conserved regulator that controls cell migration and branching across species and germ layers, and PKC activation can rescue SERCA inhibition. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.

  • Open Access
    Tbx1 and Jag1 act in concert to modulate the fate of neurosensory cells of the mouse otic vesicle
    Stephania Macchiarulo, Bernice E. Morrow
    Biology Open 2017 6: 1472-1482; doi: 10.1242/bio.027359

    Summary: Normal dosages of Tbx1 and Jag1 are required to maintain a proper balance of cell types within the neurosensory domain of the otic vesicle to form the inner ear.

  • Open Access
    Molecular regulation of high muscle mass in developing Blonde d'Aquitaine cattle foetuses
    Isabelle Cassar-Malek, Céline Boby, Brigitte Picard, Antonio Reverter, Nicholas J. Hudson
    Biology Open 2017 6: 1483-1492; doi: 10.1242/bio.024950

    Summary: We explored the molecular basis of high muscle mass in Blonde d’Aquitaine cattle, and found that mRNA encoding slow fibres and mitochondrial proteins were downregulated in this breed.

  • Open Access
    How does oestradiol influence the AVT/IT system in female round gobies during different reproductive phases?
    Hanna Kalamarz-Kubiak, Magdalena Gozdowska, Tatiana Guellard, Ewa Kulczykowska
    Biology Open 2017 6: 1493-1501; doi: 10.1242/bio.024844

    Summary: This in vitro gradient perfusion study presents a presumable mechanism of 17β-oestradiol action on the AVT/IT system in the female round goby during different phases of the reproductive cycle.

  • Open Access
    CLASP1 regulates endothelial cell branching morphology and directed migration
    Nicole M. Myer, Kenneth A. Myers
    Biology Open 2017 6: 1502-1515; doi: 10.1242/bio.028571

    Summary: CLASP1 modulates microtubule dynamics with sub-cellular specificity in response to extracellular matrix density and composition. CLASP1 effects on microtubules promote short, branched protrusions that guide persistent and directional EC migration. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.

  • Open Access
    Influence of a GSK3β phosphorylation site within the proximal C-terminus of Neurofilament-H on neurofilament dynamics
    Rishel Brenna Vohnoutka, Edward F. Boumil, Yuguan Liu, Atsuko Uchida, Harish C. Pant, Thomas B. Shea
    Biology Open 2017 6: 1516-1527; doi: 10.1242/bio.028522

    Summary: We demonstrate that phosphorylation of a critical site regulates neurofilament transport, proteolysis and interaction with other axonal cytoskeletal elements, and present evidence that it does so by altering protein conformation. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.

  • Open Access
    Vestigial-like 3 is a novel Ets1 interacting partner and regulates trigeminal nerve formation and cranial neural crest migration
    Emilie Simon, Nadine Thézé, Sandrine Fédou, Pierre Thiébaud, Corinne Faucheux
    Biology Open 2017 6: 1528-1540; doi: 10.1242/bio.026153

    Summary: Here, we provide the first description of Vgll3 function during vertebrate development. Vgll3 is a new partner of Ets1 and regulates trigeminal nerve formation and cranial neural crest cell migration.

  • Open Access
    Forces to pierce cuticle of tarsi and material properties determined by nanoindentation: The Achilles’ heel of bed bugs
    Jorge Bustamante, Jason F. Panzarino, Timothy J. Rupert, Catherine Loudon
    Biology Open 2017 6: 1541-1551; doi: 10.1242/bio.028381

    Summary: Mechanical properties were measured for bed bug cuticle of the tarsi to evaluate physical plant defenses and to inform the development of novel biomimetic physical insecticides.

  • Open Access
    The terminal nerve plays a prominent role in GnRH-1 neuronal migration independent from proper olfactory and vomeronasal connections to the olfactory bulbs
    Ed Zandro M. Taroc, Aparna Prasad, Jennifer M. Lin, Paolo E. Forni
    Biology Open 2017 6: 1552-1568; doi: 10.1242/bio.029074

    Summary: Our work reveals that correct olfactory bulb development is not required for GnRH-1 neuronal migration. This study challenges the idea that GnRH-1 neuronal migration to the hypothalamus relies on correct routing of the olfactory and vomeronasal neurons and supports the existence of the TN in mammals.

  • Open Access
    Grazing limits natural biological controls of woody encroachment in Inner Mongolia Steppe
    Hongyu Guo, Linjing Guan, Yinhua Wang, Lina Xie, Chelse M. Prather, Chunguang Liu, Chengcang Ma
    Biology Open 2017 6: 1569-1574; doi: 10.1242/bio.026443

    Summary: Grazing can negatively affect herbivorous insects and parasitic plants on woody plants, and thus limit the effectiveness of their natural biological control effects on woody encroachment.

METHODS & TECHNIQUES

  • Open Access
    Quantitative analysis of mechanical force required for cell extrusion in zebrafish embryonic epithelia
    Sohei Yamada, Takanori Iino, Yasumasa Bessho, Yoichiroh Hosokawa, Takaaki Matsui
    Biology Open 2017 6: 1575-1580; doi: 10.1242/bio.027847

    Summary: In this study a novel in vivo force quantification system was developed, which succeeded in estimating the magnitude of force required for extrusion of a dying cell from zebrafish embryonic epithelia.

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    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
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    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
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    Bishal Basak, Harini Krishnan, Raghu Padinjat
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