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  You have access

  Open access

May 15, 2017; 6 (5)

RESEARCH ARTICLES

  • Open Access
    A role for planar cell polarity during early endoderm morphogenesis
    Lee B. Miles, Takamasa Mizoguchi, Yutaka Kikuchi, Heather Verkade
    Biology Open 2017 6: 531-539; doi: 10.1242/bio.021899

    Summary: Here we characterise endodermal morphogenesis during somitogenesis stages, and show that PCP signalling plays a mixed role in endoderm development during these stages.

  • Open Access
    A novel proteolytic event controls Hedgehog intracellular sorting and distribution to receptive fields
    Joseph R. Daniele, Tehyen Chu, Sam Kunes
    Biology Open 2017 6: 540-550; doi: 10.1242/bio.024083

    Summary: Hedgehog is a morphogen and oncogene, but what controls its distribution to release sites? We describe a novel, conserved, proteolytic event in Hedgehog processing that controls delivery to target cells.

  • Open Access
    Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin
    Elena Marcassa, Marzia Raimondi, Tahira Anwar, Eeva-Liisa Eskelinen, Michael P. Myers, Gianluca Triolo, Claudio Schneider, Francesca Demarchi
    Biology Open 2017 6: 551-562; doi: 10.1242/bio.022806

    Summary: ER stress triggers calpain-dependent Bif-1 activation and induction of autophagosome maturation by promoting ATG9/Bif-1 vesicle trafficking and fusion with LC3 bodies.

  • Open Access
    mTORC1 signalling mediates PI3K-dependent large lipid droplet accumulation in Drosophila ovarian nurse cells
    Lawrence B. Mensah, Deborah C. I. Goberdhan, Clive Wilson
    Biology Open 2017 6: 563-570; doi: 10.1242/bio.022210

    Summary: Signalling by the nutrient-sensitive mTORC1 pathway mediates the effects of elevated insulin-dependent PI3K on large lipid droplet formation in nutrient-storing nurse cells of the Drosophila ovary.

  • Open Access
    Sulphated glycosaminoglycans support an assortment of planarian rhabdite structures
    Matthew J. Hayes
    Biology Open 2017 6: 571-581; doi: 10.1242/bio.024554

    Summary: We show that the slime secreted by planarian flatworms is supported by a complex meshwork of sulphated polysaccharides. These form an assortment of geodesic structures. Similar structures could be used to provide novel biomimetic drug delivery vehicles.

  • Open Access
    Reduced β-catenin expression affects patterning of bone primordia, but not bone maturation
    Tobias Pflug, Uyen Huynh-Do, Stefan Rudloff
    Biology Open 2017 6: 582-588; doi: 10.1242/bio.023572

    Summary: The correct allocation and patterning of skeletal elements during development requires a higher dosage of β-catenin than the maturation and mineralization of these primordia.

  • Open Access
    Adhesion and friction of the smooth attachment system of the cockroach Gromphadorhina portentosa and the influence of the application of fluid adhesives
    Oliver Betz, Melina Frenzel, Michael Steiner, Martin Vogt, Malte Kleemeier, Andreas Hartwig, Benjamin Sampalla, Frank Rupp, Moritz Boley, Christian Schmitt
    Biology Open 2017 6: 589-601; doi: 10.1242/bio.024620

    Summary: Friction and adhesion of a cockroach are analysed in an experimental approach that focuses on the function of the tarsal adhesion-mediating secretion.

  • Open Access
    Mouse embryonic dorsal root ganglia contain pluripotent stem cells that show features similar to embryonic stem cells and induced pluripotent stem cells
    Ryuhei Ogawa, Kyohei Fujita, Kazuo Ito
    Biology Open 2017 6: 602-618; doi: 10.1242/bio.021758

    Summary: We showed that mouse embryonic dorsal root ganglia contain pluripotent stem cells. We found significant similarities between pluripotent stem cells and neural crest-derived stem cells.

  • Open Access
    Investigation of span-chordwise bending anisotropy of honeybee forewings
    JianGuo Ning, Yun Ma, HuiLan Ren, PengFei Zhang
    Biology Open 2017 6: 619-624; doi: 10.1242/bio.022541

    Summary: The span-chordwise bending anisotropy is due to the distribution of resilin patches, the corrugation along the span and the leading edge vein of the venation.

  • Open Access
    Differences in swimming ability and its response to starvation among male and female Gambusia affinis
    Jiangtao Li, Xiaotao Lin, Zhongneng Xu, Jun Sun
    Biology Open 2017 6: 625-632; doi: 10.1242/bio.022822

    Summary: The study explored the causes of variation in swimming performance with respect to morphological and physiological characteristics, which provides further information about environmental adaptive ability in Gambusia affinis.

  • Open Access
    Alteration of swing leg work and power during human accelerated sprinting
    Ryu Nagahara, Takeo Matsubayashi, Akifumi Matsuo, Koji Zushi
    Biology Open 2017 6: 633-641; doi: 10.1242/bio.024281

    Summary: The roles of respective swing leg joints intricately change with increases in running speed during accelerated sprinting.

  • Open Access
    Does air-breathing meet metabolic demands of the juvenile snakehead, Channa argus, in multiple conditions
    Yongli Li, Xiao Lv, Jing Zhou, Chenchen Shi, Ting Duan, Yiping Luo
    Biology Open 2017 6: 642-647; doi: 10.1242/bio.024448

    Summary: The snakehead could survive out of water by breathing air for varying lengths of time, depending on ambient temperature and metabolic demand.

  • Open Access
    Do you see what I see? Optical morphology and visual capability of ‘disco’ clams (Ctenoides ales)
    Lindsey F. Dougherty, Richard R. Dubielzig, Charles S. Schobert, Leandro B. Teixeira, Jingchun Li
    Biology Open 2017 6: 648-653; doi: 10.1242/bio.024570

    Summary: ‘Disco’ clams are known for their vivid flashing displays. Their vision was examined to see if their display is visible to other disco clams as a signal.

  • Open Access
    Cross-linking mass spectrometry identifies new interfaces of Augmin required to localise the γ-tubulin ring complex to the mitotic spindle
    Jack W. C. Chen, Zhuo A. Chen, Kacper B. Rogala, Jeremy Metz, Charlotte M. Deane, Juri Rappsilber, James G. Wakefield
    Biology Open 2017 6: 654-663; doi: 10.1242/bio.022905

    Summary: A map of subunit positional restrictions in Drosophila Augmin shows that Dgt3, Dgt5 and Dgt6 are all required to localise gamma-TuRC to mitotic spindles.

  • Open Access
    Trehalose metabolism genes of Aphelenchoides besseyi (Nematoda: Aphelenchoididae) in hypertonic osmotic pressure survival
    Qiaoli Chen, Danlei Li, Feng Wang, Ruizhi Zhang, Yaming Ling
    Biology Open 2017 6: 664-672; doi: 10.1242/bio.023267

    Summary: Trehalose metabolism genes should play a role in osmobiosis regulation and also function within a restricted time frame. Silence of any of these genes will cut down the nematode survival under hypertonic osmotic condition.

METHODS & TECHNIQUES

  • Open Access
    Parallel in vivo monitoring of pH in gill capillaries and muscles of fishes using microencapsulated biomarkers
    Ekaterina Borvinskaya, Anton Gurkov, Ekaterina Shchapova, Boris Baduev, Zhanna Shatilina, Anton Sadovoy, Igor Meglinski, Maxim Timofeyev
    Biology Open 2017 6: 673-677; doi: 10.1242/bio.024380

    Summary: An optical technique for the simultaneous in vivo monitoring of pH in the blood of gill capillaries and interstitial fluid of muscles developed and tested in zebrafish.

  • Open Access
    Visualizing endoderm cell populations and their dynamics in the mouse embryo with a Hex-tdTomato reporter
    Tao Wu, Anna-Katerina Hadjantonakis, Sonja Nowotschin
    Biology Open 2017 6: 678-687; doi: 10.1242/bio.024638

    Summary: A red fluorescent reporter under the regulatory control of the mouse Hex gene permits identification of different endodermal populations and visualization of dynamic cellular behaviors driving endoderm specification and morphogenesis.

  • Open Access
    Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis
    Colin E. Evans, Asis Palazon, Jingwei Sim, Petros A. Tyrakis, Alice Prodger, Xiao Lu, Saria Chan, Pär-Ola Bendahl, Mattias Belting, Love Von Euler, Helene Rundqvist, Randall S. Johnson, Cristina Branco
    Biology Open 2017 6: 688-697; doi: 10.1242/bio.024653

    Summary: Induction of pulmonary microthrombosis by three distinct methods enhances HIF-a expression and tumour formation; increases in tumorigenesis that are induced by these thrombotic insults occur in a time- and mode-dependent manner.

  • Open Access
    WRN conditioned media is sufficient for in vitro propagation of intestinal organoids from large farm and small companion animals
    Robin H. Powell, Michael S. Behnke
    Biology Open 2017 6: 698-705; doi: 10.1242/bio.021717

    Summary: Culturing methods for the propagation of crypt-derived mouse and human enteroids are applicable to large farm and small companion animals, demonstrating conservation of the crypt signaling microenvironment.

  • Open Access
    Culture time of vitrified/warmed zygotes before microinjection affects the production efficiency of CRISPR-Cas9-mediated knock-in mice
    Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Toru Takeo, Naomi Nakagata, Takashi Yamamoto
    Biology Open 2017 6: 706-713; doi: 10.1242/bio.025122

    Summary: We report variable production efficiencies of CRISPR-Cas9-mediated knock-in mice depending on a series of microinjection timings using vitrified, warmed, and cultured zygotes created via ultra-superovulation and in vitro fertilization.

  • Open Access
    Analysis of axonal trafficking via a novel live-imaging technique reveals distinct hedgehog transport kinetics
    Joseph R. Daniele, Rehan M. Baqri, Sam Kunes
    Biology Open 2017 6: 714-721; doi: 10.1242/bio.024075

    Summary: A novel method to directly visualize Hedgehog transport in the photoreceptor neurons of living animals offers unprecedented positional and temporal detail of complex phenotypes in real time.

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    Notch signaling governs the expression of glypican Dally to define the stem cell niche

    Songhua Zhao, Chan Wu, Zhiyang Gao, Xin Li, Guo Zheng, Zhaohui Wang
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  • Open Access

    Visualisation of ribosomes in Drosophila axons using Ribo-BiFC

    Anand K. Singh, Akilu Abdullahi, Matthias Soller, Alexandre David, Saverio Brogna
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  • Open Access

    Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease

    Juan Garrido-Maraver, Samantha H. Y. Loh, L. Miguel Martins
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  • Open Access

    Larval mannitol diets increase mortality, prolong development, and decrease adult body sizes in fruit flies (Drosophila melanogaster)

    Meghan Barrett, Katherine Fiocca, Edward A. Waddell, Cheyenne McNair, Sean O'Donnell, Daniel R. Marenda
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    The interconnection between cytokeratin and cell membrane-bound β-catenin in Sertoli cells derived from juvenile Xenopus tropicalis testes

    Thi Minh Xuan Nguyen, Marketa Vegrichtova, Tereza Tlapakova, Magdalena Krulova, Vladimir Krylov
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