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  You have access

  Open access

June, 2017; 6 (6)

RESEARCH ARTICLES

  • Open Access
    Endogenous AJAP1 associates with the cytoskeleton and attenuates angiogenesis in endothelial cells
    Katharina Hötte, Isabell Smyrek, Anna Starzinski-Powitz, Ernst H. K. Stelzer
    Biology Open 2017 6: 723-731; doi: 10.1242/bio.022335

    Summary: Depletion of AJAP1 in endothelial cells can increase angiogenic-like sprouting and cell migration. In addition, AJAP1 associates with microtubules in these cells.

  • Open Access
    Surviving murine experimental sepsis affects the function and morphology of the inner ear
    Natalie Fischer, Nina Maria Mathonia, Georges Hollerich, Julian Veser, Leyla Pinggera, Daniel Dejaco, Rudolf Glueckert, Anneliese Schrott-Fischer, Peter Lackner, Herbert Riechelmann, Joachim Schmutzhard
    Biology Open 2017 6: 732-740; doi: 10.1242/bio.024588

    Summary: This study shows that a mild sepsis leads to a significant hearing impairment due to apoptosis of different inner ear structures.

  • Open Access
    Evidence that differentiation-inducing factor-1 controls chemotaxis and cell differentiation, at least in part, via mitochondria in D. discoideum
    Yuzuru Kubohara, Haruhisa Kikuchi, Van Hai Nguyen, Hidekazu Kuwayama, Yoshiteru Oshima
    Biology Open 2017 6: 741-751; doi: 10.1242/bio.021345

    Summary: DIF-1 regulates Dictyostelium chemotaxis and differentiation. We synthesized DIF-1-BODIPY, a fluorescent DIF-1 derivative. DIF-1-BODIPY localized to mitochondria, suggesting that DIF-1 functions, at least in part, via mitochondria.

  • Open Access
    Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a
    Lisette Lange, Matthias Marks, Jinhua Liu, Lars Wittler, Hermann Bauer, Sandra Piehl, Gabriele Bläß, Bernd Timmermann, Bernhard G. Herrmann
    Biology Open 2017 6: 752-764; doi: 10.1242/bio.023200

    Summary: The tw18 lethal, a ‘classical’ mutation, affects gastrulation and embryo patterning. This article shows that phosphatase PP2A is dysfunctional in tw18 and essential for Nodal and WNT signaling in the epiblast.

  • Open Access
    Centrin diversity and basal body patterning across evolution: new insights from Paramecium
    Anne Aubusson-Fleury, Guillaume Balavoine, Michel Lemullois, Khaled Bouhouche, Janine Beisson, France Koll
    Biology Open 2017 6: 765-776; doi: 10.1242/bio.024273

    Summary: Functional and phylogenetic analyses reveal the existence of five centrin families and show that basal body patterning in Paramecium requires a third centrin present in many eukaryote lineages.

  • Open Access
    Low extracellular potassium prolongs repolarization and evokes early afterdepolarization in human induced pluripotent stem cell-derived cardiomyocytes
    Jukka Kuusela, Kim Larsson, Disheet Shah, Chandra Prajapati, Katriina Aalto-Setälä
    Biology Open 2017 6: 777-784; doi: 10.1242/bio.024216

    Summary: This is the first study showing the effects of low extracellular potassium on the electrophysiological properties of human induced pluripotent stem cell-derived long QT cardiomyocytes at single and multicellular level.

  • Open Access
    The coordinating role of IQGAP1 in the regulation of local, endosome-specific actin networks
    Edward B. Samson, David S. Tsao, Jan Zimak, R. Tyler McLaughlin, Nicholaus J. Trenton, Emily M. Mace, Jordan S. Orange, Volker Schweikhard, Michael R. Diehl
    Biology Open 2017 6: 785-799; doi: 10.1242/bio.022624

    Summary: Super-resolution imaging and multiplexed live-cell analyses indicate the multi-domain scaffold IQGAP1 contributes to a complex regulatory network that coordinates the actin encapsulation and membrane processing of a novel endosomal compartment.

  • Open Access
    Morphology and cardiac physiology are differentially affected by temperature in developing larvae of the marine fish mahi-mahi (Coryphaena hippurus)
    Prescilla Perrichon, Christina Pasparakis, Edward M. Mager, John D. Stieglitz, Daniel D. Benetti, Martin Grosell, Warren W. Burggren
    Biology Open 2017 6: 800-809; doi: 10.1242/bio.025692

    Summary: Acute and chronic temperature exposures affect differentially heart rate, stroke volume and cardiac output in mahi-mahi (Coryphaena hippurus) during early development.

  • Open Access
    Dancing attraction: followers of honey bee tremble and waggle dances exhibit similar behaviors
    Calvin Lam, Yanlei Li, Tim Landgraf, James Nieh
    Biology Open 2017 6: 810-817; doi: 10.1242/bio.025445

    Summary: We show that tremble dance and waggle dance followers exhibit similar orientation and tracking behaviors, suggesting that signal detection via following is a conserved honey bee behavior.

  • Open Access
    Simultaneous stimulation of glycolysis and gluconeogenesis by feeding in the anterior intestine of the omnivorous GIFT tilapia, Oreochromis niloticus
    Yong-Jun Chen, Ti-Yin Zhang, Hai-Yan Chen, Shi-Mei Lin, Li Luo, De-Shou Wang
    Biology Open 2017 6: 818-824; doi: 10.1242/bio.024836

    Summary: Simultaneous stimulation of glycolysis and gluconeogenesis by feeding in the anterior intestine of the omnivorous GIFT tilapia, Oreochromis niloticus.

  • Open Access
    Prohibitin-induced obesity leads to anovulation and polycystic ovary in mice
    Sudharsana Rao Ande, Khanh Hoa Nguyen, Yang Xin Zi Xu, Suresh Mishra
    Biology Open 2017 6: 825-831; doi: 10.1242/bio.023416

    Summary: Obesity-related overgrowth of periovarian adipose tissue and elevated estradiol levels cause anovulation and ovarian cyst formation in mice, independent of hyperinsulinemia and hyperandrogenism.

  • Open Access
    Arabidopsis DNA topoisomerase I alpha is required for adaptive response to light and flower development
    Evgenia V. Kupriyanova, Evgeniy V. Albert, Aleksandra I. Bliznina, Polina O. Mamoshina, Tatiana A. Ezhova
    Biology Open 2017 6: 832-843; doi: 10.1242/bio.024422

    Summary: This study expands upon the existing knowledge of Arabidopsis DNA topoisomerase gene TOP1α function in plant development and demonstrates its important new role in regulating shade response and flower development.

  • Open Access
    Fission yeast neddylation ligase Dcn1 facilitates cohesin cleavage and chromosome segregation at anaphase
    Lan Lin, Li Chen, Phong T. Tran
    Biology Open 2017 6: 844-849; doi: 10.1242/bio.021238

    Summary: The fission yeast neddylation ligase Dcn1 plays a role in chromosome segregation. dcn1-deletion results in activation of the Mad2-dependent spindle assembly checkpoint, and lagging chromosomes at anaphase.

  • Open Access
    Akt3 is responsible for the survival and proliferation of embryonic stem cells
    Ling Wang, Delun Huang, Zongliang Jiang, Yan Luo, Carol Norris, Ming Zhang, Xiuchun Tian, Young Tang
    Biology Open 2017 6: 850-861; doi: 10.1242/bio.024505

    Summary: We identified that Akt isoform 3, but not Akt1 or Akt2, specifically regulates embryonic stem cell survival and proliferation. Mechanistically, this is achieved partially through controlling the p53 pathway activity.

  • Open Access
    The role of nitric oxide during embryonic epidermis development of Xenopus laevis
    Silvie Tomankova, Pavel Abaffy, Radek Sindelka
    Biology Open 2017 6: 862-871; doi: 10.1242/bio.023739

    Summary: Embryonic epidermis development is influenced by nitric oxide, where it has been linked to the development of ionocytes, multi-ciliated cells and small secretory cells.

  • Open Access
    The geometric framework for nutrition reveals interactions between protein and carbohydrate during larval growth in honey bees
    Bryan R. Helm, Garett P. Slater, Arun Rajamohan, George D. Yocum, Kendra J. Greenlee, Julia H. Bowsher
    Biology Open 2017 6: 872-880; doi: 10.1242/bio.022582

    Summary: Protein to carbohydrate ratio affects the survival and growth rate of larval worker honey bees in vitro. Protein and carbohydrate content of food interact in complex ways to alter growth rate, development time and survival in worker bound honey bee larvae.

  • Open Access
    Pias3 is necessary for dorso-ventral patterning and visual response of retinal cones but is not required for rod photoreceptor differentiation
    Christie K. Campla, Hannah Breit, Lijin Dong, Jessica D. Gumerson, Jerome E. Roger, Anand Swaroop
    Biology Open 2017 6: 881-890; doi: 10.1242/bio.024679

    Summary: Loss of Pias3 in mice results in altered dorso-ventral patterning of retinal cone photoreceptors by modulating the expression of a subset of genes, but does not affect rod development.

  • Open Access
    Senescence gives insights into the morphogenetic evolution of anamniotes
    Éric Villiard, Jean-François Denis, Faranak Sadat Hashemi, Sebastian Igelmann, Gerardo Ferbeyre, Stéphane Roy
    Biology Open 2017 6: 891-896; doi: 10.1242/bio.025809

    Summary: We report the presence of senescent cells in several transient structures in developing amphibian and teleost fish, suggesting novel mechanisms of morphogenesis that appeared early in vertebrate evolution.

  • Open Access
    Dietary supplementation of heat-treated Gracilaria and Ulva seaweeds enhanced acute hypoxia tolerance in gilthead sea bream (Sparus aurata)
    Leonardo J. Magnoni, Juan Antonio Martos-Sitcha, Augusto Queiroz, Josep Alvar Calduch-Giner, José Fernando Magalhães Gonçalves, Cristina M. R. Rocha, Helena T. Abreu, Johan W. Schrama, Rodrigo O. A. Ozorio, Jaume Pérez-Sánchez
    Biology Open 2017 6: 897-908; doi: 10.1242/bio.024299

    Summary: The physiological response and survival rate of gilthead sea bream to hypoxia was highly modulated by dietary supplementation of heat-treated seaweed.

  • Open Access
    Transition zone cells reach G2 phase before initiating elongation in maize root apex
    M. Victoria Alarcón, Julio Salguero
    Biology Open 2017 6: 909-913; doi: 10.1242/bio.025015

    Summary: Meristematic root cells stop cycling in G2 phase before entering the elongation zone. Remarkable changes in the percentage of cells in the cell cycle phases take place in the transition zone, indicating this zone is a boundary between mitotic and elongation cell processes.

  • Open Access
    Epstein-Barr virus-encoded LMP2A stimulates migration of nasopharyngeal carcinoma cells via the EGFR/Ca2+/calpain/ITGβ4 axis
    Jiezhen Liang, Shixing Zheng, Xue Xiao, Jiazhang Wei, Zhe Zhang, Ingemar Ernberg, Liudmila Matskova, Guangwu Huang, Xiaoying Zhou
    Biology Open 2017 6: 914-922; doi: 10.1242/bio.024646

    Summary: LMP2A expression in nasopharyngeal carcinoma cells increases EGFR activation and cytosolic Ca2+, subsequently stimulates calpain-dependent cleavage of ITGβ4 and enhances cell motility.

METHODS & TECHNIQUES

  • Open Access
    Labeling glycans on living cells by a chemoenzymatic glycoengineering approach
    Ruben T. Almaraz, Yanhong Li
    Biology Open 2017 6: 923-927; doi: 10.1242/bio.021600

    Summary: A novel chemoenzymatic glycoengineering method was developed to selectively modify and label surface glycoconjugates in living cells by implementing glycosyltransferases and azido-modified activated sugar analogs.

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Biology Open: 6 (6)
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    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
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  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
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  • Open Access

    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
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  • Open Access

    Conditional targeting of phosphatidylserine decarboxylase to lipid droplets

    Santosh Kumar, Chandramohan Chitraju, Robert Farese, Tobias Walther, Christopher G. Burd
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  • Open Access

    The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)

    Kun Guo, Jun Zhong, Lin Zhu, Fan Xie, Yu Du, Xiang Ji
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