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  You have access

  Open access

July, 2017; 6 (7)

Editorial

  • Open Access
    Happy 5th Birthday Biology Open
    Jordan W. Raff, Rachel Hackett
    Biology Open 2017 6: 929-930; doi: 10.1242/bio.027508

RESEARCH ARTICLES

  • Open Access
    Intra-generational protein malnutrition impairs temporal astrogenesis in rat brain
    Aijaz Ahmad Naik, Nisha Patro, Pankaj Seth, Ishan K. Patro
    Biology Open 2017 6: 931-942; doi: 10.1242/bio.023432

    Summary: Maternal protein deprivation results in low progenitor pooling, and delayed and compromised astrogenesis, suggesting astrocyte impairment as a driver of neurological diseases owing to their imperative roles in normal and pathological situations.

  • Open Access
    Proteomic responses to elevated ocean temperature in ovaries of the ascidian Ciona intestinalis
    Chelsea E. Lopez, Hannah C. Sheehan, David A. Vierra, Paul A. Azzinaro, Thomas H. Meedel, Niall G. Howlett, Steven Q. Irvine
    Biology Open 2017 6: 943-955; doi: 10.1242/bio.024786

    Summary: Shotgun proteomics study of the effect of chronic elevated water temperature identifying 62 differentially expressed ovarian proteins and a model for the proteomic response mediated by PTPN11 and CrkL.

  • Open Access
    WNK1 and p38-MAPK distribution in ionocytes and accessory cells of euryhaline teleost fish implies ionoregulatory function
    W. S. Marshall, R. R. F. Cozzi, M. Spieker
    Biology Open 2017 6: 956-966; doi: 10.1242/bio.024232

    Summary: Fish opercular epithelium ionocytes and accessory cells have WNK family kinases that may regulate paracellular and transcellular ion transport.

  • Open Access
    The Drosophila LIN54 homolog Mip120 controls two aspects of oogenesis
    Mei-Hsin Cheng, Laura Andrejka, Paul J. Vorster, Albert Hinman, Joseph S. Lipsick
    Biology Open 2017 6: 967-978; doi: 10.1242/bio.025825

    Summary: Drosophila Mip120/LIN54, regulates ovarian nurse cell chromosome disassembly and germline-specific gene expression. These functions of Mip120 require its less conserved N-terminus in addition to its CXC DNA-binding and HCH protein-interaction domains.

  • Open Access
    BMP-induced reprogramming of the neural retina into retinal pigment epithelium requires Wnt signalling
    Jörg Steinfeld, Ichie Steinfeld, Alexander Bausch, Nicola Coronato, Meggi-Lee Hampel, Heike Depner, Paul G. Layer, Astrid Vogel-Höpker
    Biology Open 2017 6: 979-992; doi: 10.1242/bio.018739

    Summary: The bone morphogenetic proteins (BMPs) are key regulators in cell reprogramming during regeneration of the neural retina and retinal pigment epithelium in the embryonic chick.

  • Open Access
    Intrinsic frequency response patterns in mechano-sensory neurons of the leech
    Linda Fischer, Frank Scherbarth, Boris Chagnaud, Felix Felmy
    Biology Open 2017 6: 993-999; doi: 10.1242/bio.023960

    Summary: Mechano-sensitive neurons of leech are intrinsically tuned to generate somatic input-output functions with distinct filter properties.

  • Open Access
    Effects of altered sagittal trunk orientation on kinetic pattern in able-bodied walking on uneven ground
    Soran Aminiaghdam, Christian Rode
    Biology Open 2017 6: 1000-1007; doi: 10.1242/bio.025239

    Summary: In able-bodied trunk-flexed gaits, adjustment of trunk kinematic may facilitate negotiation of changes in ground level (10-cm drop and pre/post steps), as reflected in more consistent ground reaction force parameters.

  • Open Access
    Postmating sexual selection and the enigmatic jawed genitalia of Callosobruchus subinnotatus
    Merel M. Van Haren, Johanna Liljestrand Rönn, Menno Schilthuizen, Göran Arnqvist
    Biology Open 2017 6: 1008-1012; doi: 10.1242/bio.025684

    Summary: A toothed jaw-like structure on the male genitalia of the seed beetle Callosobruchus subinnotatus increases female egg production after mating.

  • Open Access
    Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau
    Josefin Fernius, Annika Starkenberg, Malgorzata Pokrzywa, Stefan Thor
    Biology Open 2017 6: 1013-1023; doi: 10.1242/bio.022749

    Summary: Tau hyper-phosphorylation has been linked to toxicity, but the Tau isoforms, kinases and residues remain unclear. Using the Drosophila model, we find evidence for involvement of TTBK and MARK kinases.

  • Open Access
    Characterisation of phospholipid: diacylglycerol acyltransferases (PDATs) from Camelina sativa and their roles in stress responses
    Lixia Yuan, Xue Mao, Kui Zhao, Xiajie Ji, Chunli Ji, Jinai Xue, Runzhi Li
    Biology Open 2017 6: 1024-1034; doi: 10.1242/bio.026534

    Summary: Five CsPDAT family members were identified from Camelina sativa and they contribute to TAG synthesis in different tissues and various stress responses, offering new targets for lipid metabolic engineering.

  • Open Access
    The effects of moderate intensity training in a hypoxic environment on transcriptional responses in Thoroughbred horses
    Allan J. Davie, Li Wen, Andrew R. E. Cust, Rosalind Beavers, Tom Fyfe, Shi Zhou
    Biology Open 2017 6: 1035-1040; doi: 10.1242/bio.020388

    Summary: This was one of the first studies that examined transcriptional and physiological responses of Thoroughbred racehorses to six weeks moderate intensity treadmill training in a hypoxia chamber with 15% oxygen.

  • Open Access
    Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning
    Kanako Kumamoto, Tokuichi Iguchi, Ryuichi Ishida, Takuya Uemura, Makoto Sato, Shinji Hirotsune
    Biology Open 2017 6: 1041-1055; doi: 10.1242/bio.025999

    Summary: Developmental downregulation of LIS1 coordinates the balance between axonal elongation and pruning, which is essential for proper neuronal circuit formation but limits nerve regeneration.

  • Open Access
    Establishment of a retinal hypoxia organ culture model
    S. Schnichels, M. Blak, J. Hurst, T. Dorfi, K. U. Bartz-Schmidt, F. Ziemssen, M. S. Spitzer, M. Schultheiss
    Biology Open 2017 6: 1056-1064; doi: 10.1242/bio.025429

    Summary: An easy-to-use ex vivo retinal hypoxia model is introduced that reliably induced retinal damage on a morphological (retinal thickness), and molecular (protein expression and apoptotic markers) level.

  • Open Access
    Cell lineage of timed cohorts of Tbx6-expressing cells in wild-type and Tbx6 mutant embryos
    Daniel Concepcion, Andrew J. Washkowitz, Akiko DeSantis, Phillip Ogea, Jason I. Yang, Nataki C. Douglas, Virginia E. Papaioannou
    Biology Open 2017 6: 1065-1073; doi: 10.1242/bio.026203

    Summary: Embryonic cells that transiently express the transcription factor, Tbx6, during the process of gastrulation have been tracked in later development in wild-type and Tbx6 homozygous mutant embryos, where they give rise to the ectopic neural tubes characteristic of the mutant phenotype.

  • Open Access
    Dietary saccharides and sweet tastants have differential effects on colonization of Drosophila oocytes by Wolbachia endosymbionts
    Moises Camacho, Mailin Oliva, Laura R. Serbus
    Biology Open 2017 6: 1074-1083; doi: 10.1242/bio.023895

    Summary: The density of Wolbachia infection in Drosophila oocytes is significantly increased by dietary sugars, but not sugar alcohols or artificial sweeteners.

  • Open Access
    GATA6 is essential for endoderm formation from human pluripotent stem cells
    J. B. Fisher, K. Pulakanti, S. Rao, S. A. Duncan
    Biology Open 2017 6: 1084-1095; doi: 10.1242/bio.026120

    Summary: Using the differentiation of huESCs as a model for endoderm formation, we reveal that the transcription factor GATA6 regulates the onset of endoderm gene expression and is required for its viability.

  • Open Access
    Effects of starvation on the carbohydrate metabolism in Harmonia axyridis (Pallas)
    Zuo-Kun Shi, Su Wang, Shi-Gui Wang, Lu Zhang, Yan-Xia Xu, Xiao-Jun Guo, Fan Zhang, Bin Tang
    Biology Open 2017 6: 1096-1103; doi: 10.1242/bio.025189

    Summary: Effects of starvation on the molecular and biochemical mechanisms of carbohydrate metabolism were regulated by trehalose and glycogen metabolism genes' expression changed in Harmonia axyridis (Pallas).

  • Open Access
    Symmetrical retrograde actin flow in the actin fusion structure is involved in osteoclast fusion
    Jiro Takito, Hirotada Otsuka, Satoshi Inoue, Tsubasa Kawashima, Masanori Nakamura
    Biology Open 2017 6: 1104-1114; doi: 10.1242/bio.025460

    Summary: Multinucleated osteoclasts form a podosome-derived fusion structure during cell fusion. Juxtaposition of fusion partner cells is probably maintained via force generated by symmetrical retrograde actin flow in the fusion structure.

  • Open Access
    Hagfish slime exudate stabilization and its effect on slime formation and functionality
    L. J. Böni, R. Zurflüh, M. Widmer, P. Fischer, E. J. Windhab, P. A. Rühs, S. Kuster
    Biology Open 2017 6: 1115-1122; doi: 10.1242/bio.025528

    Summary: Loss of functionality of hagfish slime exudate during storage is driven by mucin vesicle rupture when stabilized in oil and by gradually inhibited skein unraveling when stabilized in buffer.

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    Quantified growth of the human embryonic heart

    Jaeike W. Faber, Jaco Hagoort, Antoon F. M. Moorman, Vincent M. Christoffels, Bjarke Jensen
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  • Open Access

    Dissecting dynamics and differences of selective pressures in the evolution of human pigmentation

    Xin Huang, Sijia Wang, Li Jin, Yungang He
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    Auxin confers protection against ER stress in Caenorhabditis elegans

    A. Bhoi, F. Palladino, P. Fabrizio
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    Smoking flies: Testing the effect of tobacco cigarettes on heart function of Drosophila melanogaster

    Manuela Santalla, Lucía Pagola, Ivana Gómez, Darío Balcazar, Carlos A. Valverde, Paola Ferrero
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    A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and notch signaling

    Katherine K. Slemmons, Michael D. Deel, Yi-Tzu Lin, Kristianne M. Oristian, Nina Kuprasertkul, Katia C. Genadry, Po-Han Chen, Jen-Tsan Ashley Chi, Corinne M. Linardic
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