Editorial
RESEARCH ARTICLES
- Intra-generational protein malnutrition impairs temporal astrogenesis in rat brain
Summary: Maternal protein deprivation results in low progenitor pooling, and delayed and compromised astrogenesis, suggesting astrocyte impairment as a driver of neurological diseases owing to their imperative roles in normal and pathological situations.
- Proteomic responses to elevated ocean temperature in ovaries of the ascidian Ciona intestinalis
Summary: Shotgun proteomics study of the effect of chronic elevated water temperature identifying 62 differentially expressed ovarian proteins and a model for the proteomic response mediated by PTPN11 and CrkL.
- WNK1 and p38-MAPK distribution in ionocytes and accessory cells of euryhaline teleost fish implies ionoregulatory function
Summary: Fish opercular epithelium ionocytes and accessory cells have WNK family kinases that may regulate paracellular and transcellular ion transport.
- The Drosophila LIN54 homolog Mip120 controls two aspects of oogenesis
Summary: Drosophila Mip120/LIN54, regulates ovarian nurse cell chromosome disassembly and germline-specific gene expression. These functions of Mip120 require its less conserved N-terminus in addition to its CXC DNA-binding and HCH protein-interaction domains.
- BMP-induced reprogramming of the neural retina into retinal pigment epithelium requires Wnt signalling
Summary: The bone morphogenetic proteins (BMPs) are key regulators in cell reprogramming during regeneration of the neural retina and retinal pigment epithelium in the embryonic chick.
- Intrinsic frequency response patterns in mechano-sensory neurons of the leech
Summary: Mechano-sensitive neurons of leech are intrinsically tuned to generate somatic input-output functions with distinct filter properties.
- Effects of altered sagittal trunk orientation on kinetic pattern in able-bodied walking on uneven ground
Summary: In able-bodied trunk-flexed gaits, adjustment of trunk kinematic may facilitate negotiation of changes in ground level (10-cm drop and pre/post steps), as reflected in more consistent ground reaction force parameters.
- Postmating sexual selection and the enigmatic jawed genitalia of Callosobruchus subinnotatus
Summary: A toothed jaw-like structure on the male genitalia of the seed beetle Callosobruchus subinnotatus increases female egg production after mating.
- Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau
Summary: Tau hyper-phosphorylation has been linked to toxicity, but the Tau isoforms, kinases and residues remain unclear. Using the Drosophila model, we find evidence for involvement of TTBK and MARK kinases.
- Characterisation of phospholipid: diacylglycerol acyltransferases (PDATs) from Camelina sativa and their roles in stress responses
Summary: Five CsPDAT family members were identified from Camelina sativa and they contribute to TAG synthesis in different tissues and various stress responses, offering new targets for lipid metabolic engineering.
- The effects of moderate intensity training in a hypoxic environment on transcriptional responses in Thoroughbred horses
Summary: This was one of the first studies that examined transcriptional and physiological responses of Thoroughbred racehorses to six weeks moderate intensity treadmill training in a hypoxia chamber with 15% oxygen.
- Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning
Summary: Developmental downregulation of LIS1 coordinates the balance between axonal elongation and pruning, which is essential for proper neuronal circuit formation but limits nerve regeneration.
- Establishment of a retinal hypoxia organ culture model
Summary: An easy-to-use ex vivo retinal hypoxia model is introduced that reliably induced retinal damage on a morphological (retinal thickness), and molecular (protein expression and apoptotic markers) level.
- Cell lineage of timed cohorts of Tbx6-expressing cells in wild-type and Tbx6 mutant embryos
Summary: Embryonic cells that transiently express the transcription factor, Tbx6, during the process of gastrulation have been tracked in later development in wild-type and Tbx6 homozygous mutant embryos, where they give rise to the ectopic neural tubes characteristic of the mutant phenotype.
- Dietary saccharides and sweet tastants have differential effects on colonization of Drosophila oocytes by Wolbachia endosymbionts
Summary: The density of Wolbachia infection in Drosophila oocytes is significantly increased by dietary sugars, but not sugar alcohols or artificial sweeteners.
- GATA6 is essential for endoderm formation from human pluripotent stem cells
Summary: Using the differentiation of huESCs as a model for endoderm formation, we reveal that the transcription factor GATA6 regulates the onset of endoderm gene expression and is required for its viability.
- Effects of starvation on the carbohydrate metabolism in Harmonia axyridis (Pallas)
Summary: Effects of starvation on the molecular and biochemical mechanisms of carbohydrate metabolism were regulated by trehalose and glycogen metabolism genes' expression changed in Harmonia axyridis (Pallas).
- Symmetrical retrograde actin flow in the actin fusion structure is involved in osteoclast fusion
Summary: Multinucleated osteoclasts form a podosome-derived fusion structure during cell fusion. Juxtaposition of fusion partner cells is probably maintained via force generated by symmetrical retrograde actin flow in the fusion structure.
- Hagfish slime exudate stabilization and its effect on slime formation and functionality
Summary: Loss of functionality of hagfish slime exudate during storage is driven by mucin vesicle rupture when stabilized in oil and by gradually inhibited skein unraveling when stabilized in buffer.
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