RESEARCH ARTICLES
- Phosphorylation of SNAP-23 regulates its dynamic membrane association during mast cell exocytosis
Summary: The current study has revealed the phosphorylation-dependent dynamic nature of membrane association of SNAP-23 for mediation of different fusion steps in compound exocytosis from mast cells during allergen challenge.
- Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development
Summary: The transcription factors Dlx3b and Dlx4b control the formation of early-born sensory hair cells or tether cells in the developing zebrafish inner ear.
- EsGLUT4 and CHHBP are involved in the regulation of glucose homeostasis in the crustacean Eriocheir sinensis
Summary: Here we identified that Glucose transporter 4 (GLUT4) could interact with CHH binding protein (CHHBP) to regulate CHH-stimulated glucose release in Eriocheir sinensis.
- The probability of wing damage in the dragonfly Sympetrum vulgatum (Anisoptera: Libellulidae): a field study
Summary: This study provides the first qualitative and quantitative data on the occurrence of damage in the wings of the dragonfly Sympetrum vulgatum in nature. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.
- Fat-containing cells are eliminated during Dictyostelium development
Summary: In contrast to many living organisms, storage fat is not beneficial for Dictyostelium cells when progressing through starvation and subsequent development of a dormant stage.
- Standard metabolic rate predicts growth trajectory of juvenile Chinese crucian carp (Carassius auratus) under changing food availability
Summary: Our study documented how the relationship between variation in standard metabolic rate and growth is altered by the food availability in fish.
- Targeting long non-coding RNA DANCR inhibits triple negative breast cancer progression
Summary: Targeting LncRNA DANCR obstructs triple negative breast cancer progression by down-regulating cancer stem cell marker CD44 and ABCG2.
- Metabolomics reveals variation and correlation among different tissues of olive (Olea europaea L.)
Summary: This work provides the first comprehensive metabolomic of olive, which will provide new insights into understanding the olive metabolism and potentially help advance studies in olive metabolic engineering.
- WASP-Arp2/3-dependent actin polymerization influences fusogen localization during cell-cell fusion in Caenorhabditis elegans embryos
Summary: WASP-Arp2/3 regulates fusogen localization to intracellular vesicles in C. elegans embryos. Our results indicate that cell-cell fusions rely on distinct mechanisms at different developmental stages.
- The effects of the exopolysaccharide and growth rate on the morphogenesis of the terrestrial filamentous cyanobacterium Nostoc flagelliforme
Summary: By examining the effects of the exopolysaccharide and environmental stress-related growth rate on Nostoc flagelliforme, this study gained insight into the morphogenesis of the colonial cyanobacterium.
- The expression of Ldh-c in the skeletal muscle of plateau pika (Ochotona curzoniae) enhances adaptation to a hypoxic environment
Summary: The expression of Ldh-c in the skeletal muscle of plateau pika (Ochotona curzoniae) increases anaerobic glycolysis, resulting in enhanced sprint-running capacity and adaptation to a hypoxic environment.
- Regulatory RNPs: a novel class of ribonucleoproteins that potentially contribute to ribosome heterogeneity
Summary: Processed scaRNAs give rise to a novel regulatory RNP, which regulates the modification of ribosomal RNA. These findings provide insight into the mechanisms governing ribosome heterogeneity.
- PQN-75 is expressed in the pharyngeal gland cells of Caenorhabditis elegans and is dispensable for germline development
Summary: PQN-75 is expressed in pharyngeal gland cells and shares similarity with human basic salivary proline-rich protein PBR2, suggesting evolutionary conservation between gland cells in the upper digestive tract.
- Distinct intestinal adaptation for vitamin B12 and bile acid absorption revealed in a new mouse model of massive ileocecal resection
Summary: Genes involved in region-specific functions of the distal small intestine show distinct adaptive response following massive ileocecal resection in mice.
- Differential expression of sirtuin 2 and adipocyte maturation restriction: an adaptation process during hypoxia in fish
Summary: Adipocyte maturation restriction is tightly regulated by SIRT2 activation which downregulates preadipocytes from the maturation process as adaptation strategy in fish surviving in the polluted (hypoxic) environment.
- Architectural delineation and molecular identification of extracellular matrix in ascidian embryos and larvae
Summary: This study reveals the architecture, molecular composition and dynamic expression profile of the extracellular matrix in ascidian embryos and larvae, providing clues for its function in chordate development.
METHODS & TECHNIQUES
- An ex vivo model using human peritoneum to explore mesh-tissue integration
Summary: This study developed a human experimental model for long-term studies using peritoneal tissue to evaluate integration with different materials, such as synthetic meshes.
- The utility of accelerometers to predict stroke rate in captive fur seals and sea lions
Summary: Accelerometer data collected from captive fur seals and sea lions swimming were used to determine the best method for processing raw data to achieve the highest accuracy of stroke rate.
This issue
Other journals from The Company of Biologists
First person interviews — Kim, Isabel and Antonio
In the latest interviews with early-career authors of our papers, Antonio Barral, Isabel Rollan and Kim Nguyen discuss their scientific backgrounds, research and future directions.
We're excited to be an affiliate journal for Review Commons, the ASAPbio/EMBO platform for high-quality journal-independent peer-review in the life sciences, which went live on 09 December.
On the cover of issue 11, Tawari, Wodarz et al. identify CG4038 as a gene downregulated in bam mutant ovaries in an RNA-seq transcriptome analysis.
Dates for 2020 — Grants, Meetings and Workshops
Get ahead and update your 2020 diary with our meeting grant deadlines! The Company of Biologists also has a fantastic line-up of Workshops with funded places for early-career researchers and larger Journal Meetings from our sister journals Development, Journal of Cell Science, Journal of Experimental Biology and Disease, Models & Mechanisms.
Why publish with BiO?
Biology Open aims to provide rapid publication for scientifically sound observations and valid conclusions in developmental, cell, experimental and translational biology. Submit your paper for an easy and fast publication process. Recent highlights in BiO by Maldonado, Morillo-Velarde et al. discuss Octopus insularis as a new marine model for evolutionary developmental biology.