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  Open access

January, 2018; 7 (1)

MEETING REVIEW

  • Open Access
    Current status and future directions of Lévy walk research
    Andy M. Reynolds
    Biology Open 2018 7: bio030106 doi: 10.1242/bio.030106 Published 11 January 2018

    Summary: Movement patterns resembling Lévy walks are found in a wide variety of organisms, from cells to humans. In this Review the latest research into their origins and biological significance is discussed.

RESEARCH ARTICLES

  • Open Access
    Dnd1-mediated epigenetic control of teratoma formation in mouse
    Wei Gu, Kentaro Mochizuki, Kei Otsuka, Ryohei Hamada, Asuka Takehara, Yasuhisa Matsui
    Biology Open 2018 7: bio032318 doi: 10.1242/bio.032318 Published 29 January 2018

    Summary: Teratoma development from primordial germ cells is repressed by downregulation of Ccnd1 via histone H3 lysine 27 methylation controlled by Dnd1-mediated maintenance of Ezh2.

  • Open Access
    Niclosamide rescues microcephaly in a humanized in vivo model of Zika infection using human induced neural stem cells
    Dana M. Cairns, Devi Sai Sri Kavya Boorgu, Michael Levin, David L. Kaplan
    Biology Open 2018 7: bio031807 doi: 10.1242/bio.031807 Published 29 January 2018

    Summary: Injecting hiNSCs into developing chick brains and systemically infecting with ZIKV produces embryos with severe microcephaly. Using this humanized model we show that niclosamide rescues ZIKV-induced microcephaly and decreases infection of hiNSCs in vivo.

  • Open Access
    A dual role of the extracellular domain of Drosophila Crumbs for morphogenesis of the embryonic neuroectoderm
    Shradha Das, Elisabeth Knust
    Biology Open 2018 7: bio031435 doi: 10.1242/bio.031435 Published 26 January 2018

    Summary: Using a transgenomic approach we determine specific roles of the intra- and extracellular domain of the Crumbs protein for the maintenance of apico-basal epithelial polarity and epithelial morphogenesis in Drosophila embryos.

  • Open Access
    miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila
    Scott G. Daniel, Atlantis D. Russ, Kathryn M. Guthridge, Ammad I. Raina, Patricia S. Estes, Linda M. Parsons, Helena E. Richardson, Joyce A. Schroeder, Daniela C. Zarnescu
    Biology Open 2018 7: bio027391 doi: 10.1242/bio.027391 Published 26 January 2018

    Summary: Mir-9a overexpression can suppress the overgrowth phenotype caused by Lgl knock-down in epithelia. Gene profiling identifies pathways dysregulated in lgl mutants and shared features between flies and human cancer cells.

  • Open Access
    The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of β-catenin, a GSK3 substrate, in human glioblastoma cells
    Ata ur Rahman Mohammed Abdul, Bhagya De Silva, Ronald K. Gary
    Biology Open 2018 7: bio030874 doi: 10.1242/bio.030874 Published 26 January 2018

    Summary: GSK3 inhibitors have potential use against Alzheimer's disease and other conditions. In this study, a classic inhibitor produced unexpected molecular effects on key components of the Wnt signaling pathway.

  • Open Access
    Assembly and turnover of neurofilaments in growing axonal neurites
    Edward F. Boumil, Rishel Vohnoutka, Sangmook Lee, Harish Pant, Thomas B. Shea
    Biology Open 2018 7: bio028795 doi: 10.1242/bio.028795 Published 26 January 2018

    Summary: Immunofluorescent and radiolabel analyses demonstrate that neurofilaments establish a resident population within growing axonal neurites that undergoes exchange with a surrounding, transporting pool.

  • Open Access
    Compensation for chronic oxidative stress in ALADIN null mice
    Ramona Jühlen, Mirko Peitzsch, Sebastian Gärtner, Dana Landgraf, Graeme Eisenhofer, Angela Huebner, Katrin Koehler
    Biology Open 2018 7: bio030742 doi: 10.1242/bio.030742 Published 23 January 2018

    Summary: ALADIN knock-out mice present with an unexpected compensated metabolism of glutathione after application of chronic oxidative stress, whilst lacking a phenotype resembling human triple A syndrome.

  • Open Access
    Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
    Vadim Grigura, Megan Barbier, Anna P. Zarov, Charles K. Kaufman
    Biology Open 2018 7: bio030726 doi: 10.1242/bio.030726 Published 23 January 2018

    Summary: The rate of tumor formation in a BRAF-driven zebrafish melanoma model can be significantly altered by increased feeding and opens a new avenue for studying the underlying metabolic pathways involved.

  • Open Access
    QTL mapping for microtuber dormancy and GA3 content in a diploid potato population
    Raja Mohib Muazzam Naz, Mengtai Li, Safia Ramzan, Gege Li, Jun Liu, Xingkui Cai, Conghua Xie
    Biology Open 2018 7: bio027375 doi: 10.1242/bio.027375 Published 23 January 2018

    Summary: Quantitative trait locus’ (QTLs) for dormancy and gibberellic acid production in potato are localized to the same genomic region in potato.

  • Open Access
    Functional analysis of thyroid hormone receptor beta in Xenopus tropicalis founders using CRISPR-Cas
    Yuto Sakane, Midori Iida, Takashi Hasebe, Satoshi Fujii, Daniel R. Buchholz, Atsuko Ishizuya-Oka, Takashi Yamamoto, Ken-ichi T. Suzuki
    Biology Open 2018 7: bio030338 doi: 10.1242/bio.030338 Published 22 January 2018

    Summary: Using knocked-out Xenopus tropicalis founders generated by CRISPR-Cas, TRβ was shown to have significant effects on developmental timing but is not required for completion of metamorphosis.

  • Open Access
    LIF-activated Jak signaling determines Esrrb expression during late-stage reprogramming
    Delun Huang, Ling Wang, Jingyue Duan, Chang Huang, Xiuchun (Cindy) Tian, Ming Zhang, Young Tang
    Biology Open 2018 7: bio029264 doi: 10.1242/bio.029264 Published 22 January 2018

    Summary: Esrrb is a downstream target and effector of LIF during reprogramming. Forced Esrrb expression accelerates pluripotency establishment in the absence of LIF signaling. The activation of Esrrb is LIF dependent in the reprogramming process.

  • Open Access
    Hepatic metabolomic profiling changes along with postnatal liver maturation in breeder roosters
    Shengru Wu, Yanli Liu, Liqin Zhu, Di Han, Musa Bello Bodinga, Xiaojun Yang
    Biology Open 2018 7: bio028944 doi: 10.1242/bio.028944 Published 22 January 2018

    Summary: This study revealed that hepatic metabolomic changes are related to functional adaption in breeder roosters, which contribute to a better understanding of the hepatic metabolites composition differences during different periods.

  • Open Access
    An ancient conserved role for prion protein in learning and memory
    Patricia L. A. Leighton, Nathan J. Nadolski, Adam Morrill, Trevor J. Hamilton, W. Ted Allison
    Biology Open 2018 7: bio025734 doi: 10.1242/bio.025734 Published 22 January 2018

    Summary: Prion protein dysfunction at the synapse impacts learning in Alzheimer disease. Here, we demonstrate similar roles for prion protein in zebrafish, revealing ancient constructive roles for this infamously toxic protein.

  • Open Access
    Using genetic buffering relationships identified in fission yeast to reveal susceptibilities in cells lacking hamartin or tuberin function
    Ashyad Rayhan, Adam Faller, Ryan Chevalier, Alannah Mattice, Jim Karagiannis
    Biology Open 2018 7: bio031302 doi: 10.1242/bio.031302 Published 17 January 2018

    Summary: We exploit the BioGRID gene interaction database to identify and characterize susceptibilities in fission yeast cells lacking tsc1 or tsc2, orthologs of the human TSC1 and TSC2 tumor suppressor genes.

  • Open Access
    JAK signaling regulates germline cyst breakdown and primordial follicle formation in mice
    Kun Huang, Ye Wang, Tuo Zhang, Meina He, Guanghong Sun, Jia Wen, Hao Yan, Han Cai, Changfu Yong, Guoliang Xia, Chao Wang
    Biology Open 2018 7: bio029470 doi: 10.1242/bio.029470 Published 17 January 2018

    Summary: This research clarifies the important and distinct roles of JAK family members in primordial follicle formation of female mammals, and further explore the regulation mechanism of primordial follicle formation.

  • Open Access
    Chitin protects the gut epithelial barrier in a protochordate model of DSS-induced colitis
    Assunta Liberti, Ivana Zucchetti, Daniela Melillo, Diana Skapura, Yoshimi Shibata, Rosaria De Santis, Maria Rosaria Pinto, Gary W. Litman, Larry J. Dishaw
    Biology Open 2018 7: bio029355 doi: 10.1242/bio.029355 Published 17 January 2018

    Summary: The protochordate, Ciona intestinalis, is defining conserved properties of gut mucosal barriers and inflammatory processes. Diverse model systems can benefit studies concerning human pathologies of the gut.

  • Open Access
    Gelsolin regulates proliferation, apoptosis and invasion in natural killer/T-cell lymphoma cells
    Yanwei Guo, Hongqiao Zhang, Xin Xing, Lijuan Wang, Jian Zhang, Lin Yan, Xiaoke Zheng, Mingzhi Zhang
    Biology Open 2018 7: bio027557 doi: 10.1242/bio.027557 Published 17 January 2018

    Summary: GSN can suppress cell proliferation and invasion and promote apoptosis of YTS cells, and the PI3K/AKT signaling pathway is likely to be involved in this process.

  • Open Access
    Insulin regulates multiple signaling pathways leading to monocyte/macrophage chemotaxis into the wound tissue
    Yan Liu, Sandeep Dhall, Anthony Castro, Alex Chan, Raquelle Alamat, Manuela Martins-Green
    Biology Open 2018 7: bio026187 doi: 10.1242/bio.026187 Published 17 January 2018

    Summary: Insulin regulates multiple signaling pathways leading to monocyte/macrophage chemotaxis into the wound tissue, involving -Akt, SPAK/JNK, and p38 MAPK which in turn are involved in Rac1 activation. Furthermore, these results augment our understanding of the insulin-regulated wound inflammatory response.

  • Open Access
    Pharmacologic inhibition of phospholipase C in the brain attenuates early memory formation in the honeybee (Apis mellifera L.)
    Shota Suenami, Shiori Iino, Takeo Kubo
    Biology Open 2018 7: bio028191 doi: 10.1242/bio.028191 Published 12 January 2018

    Summary: Intracellular signaling involved in early memory formation in insects is not fully understood. Here, we pharmacologically elucidated the role of phospholipase C in learning and memory in the honeybee.

  • Open Access
    Phosphatase PP2A and microtubule-mediated pulling forces disassemble centrosomes during mitotic exit
    Stephen J. Enos, Martin Dressler, Beatriz Ferreira Gomes, Anthony A. Hyman, Jeffrey B. Woodruff
    Biology Open 2018 7: bio029777 doi: 10.1242/bio.029777 Published 12 January 2018

    Summary: Centrosomes acquire and lose pericentriolar material during each cell cycle. We show that dephosphorylation and cortically directed forces disassemble pericentriolar material at the end of mitosis.

  • Open Access
    Selection against BALB/c strain cells in mouse chimaeras
    Pin-Chi Tang, Gillian E. MacKay, Jean H. Flockhart, Margaret A. Keighren, Anna Kopakaki, John D. West
    Biology Open 2018 7: bio030189 doi: 10.1242/bio.030189 Published 12 January 2018

    Summary: BALB/c strain embryos contributed poorly to mouse aggregation chimaeras by E8.5. Selection appears linked to slow BALB/c development and might also explain the good ES cell contribution in BALB/c↔ES-cell chimaeras.

  • Open Access
    NGF reprograms metastatic melanoma to a bipotent glial-melanocyte neural crest-like precursor
    Jennifer C. Kasemeier-Kulesa, Morgan H. Romine, Jason A. Morrison, Caleb M. Bailey, Danny R. Welch, Paul M. Kulesa
    Biology Open 2018 7: bio030817 doi: 10.1242/bio.030817 Published 11 January 2018

    Summary: We identify and test the function of nerve growth factor to reprogram human metastatic melanoma cells to a less aggressive phenotype. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.

  • Open Access
    In vitro and in vivo differentiation of induced pluripotent stem cells generated from urine-derived cells into cardiomyocytes
    Yu-Feng Jiang, Min Chen, Nan-Nan Zhang, Hua-Jia Yang, Qing Rui, Ya-Feng Zhou
    Biology Open 2018 7: bio029157 doi: 10.1242/bio.029157 Published 8 January 2018

    Summary: We generated and verified iPS cells from urine-derived cells in a totally noninvasive manner and induced the differentiation of iPS cells into functional cardiomyocytes both in vitro and in vivo.

  • Open Access
    Thermoregulatory postures limit antipredator responses in peafowl
    Jessica L. Yorzinski, Jennifer Lam, Rachel Schultz, Melissa Davis
    Biology Open 2018 7: bio031005 doi: 10.1242/bio.031005 Published 5 January 2018

    Summary: The head-tuck and leg-tuck postures of peafowl help conserve heat but can impair antipredator responses.

  • Open Access
    A novel assessment of the traction forces upon settlement of two typical marine fouling invertebrates using PDMS micropost arrays
    Kang Xiao, Wen-Bin Cao, Cu-Huang Rong, Lian-Guo Chen, Xiao-Xue Yang, Wei-Jia Wen, Pei-Yuan Qian, Zhang-Li Hu, Ying Xu, Yu Zhang
    Biology Open 2018 7: bio030262 doi: 10.1242/bio.030262 Published 5 January 2018

    Summary: The traction forces of two typical marine fouling invertebrates were quantitatively assessed by using PDMS micropost arrays and beam-bending theory.

  • Open Access
    Distribution of PEG-coated hollow polyelectrolyte microcapsules after introduction into the circulatory system and muscles of zebrafish
    Ekaterina Borvinskaya, Anton Gurkov, Ekaterina Shchapova, Boris Baduev, Igor Meglinski, Maxim Timofeyev
    Biology Open 2018 7: bio030015 doi: 10.1242/bio.030015 Published 5 January 2018

    Summary: With remote physiological sensing in mind, the study explores the fate of fluorescent microcapsules with elastic shell after injection in bloodstream and muscles of adult zebrafish.

  • Open Access
    An attenuated quadruple gene mutant of Mycobacterium tuberculosis imparts protection against tuberculosis in guinea pigs
    Ritika Kar Bahal, Shubhita Mathur, Priyanka Chauhan, Anil K. Tyagi
    Biology Open 2018 7: bio029546 doi: 10.1242/bio.029546 Published 5 January 2018

    Summary: In this study, a mutant of M. tuberculosis with the deletion of four important genes has been evaluated in guinea pigs for its attenuation and protective efficacy against tuberculosis.

  • Open Access
    Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function
    Xin Sun, Swetansu K. Hota, Yu-Qing Zhou, Stefanie Novak, Dario Miguel-Perez, Danos Christodoulou, Christine E. Seidman, J. G. Seidman, Carol C. Gregorio, R. Mark Henkelman, Janet Rossant, Benoit G. Bruneau
    Biology Open 2018 7: bio029512 doi: 10.1242/bio.029512 Published 5 January 2018

    Summary: Genetic deletion of Baf60c leads to embryonic cardiac hypoplasia and dysfunction. Baf60c coordinates a program of gene expression that regulates the fundamental functional properties of cardiomyocytes.

METHODS & TECHNIQUES

  • Open Access
    A dual transcript-discovery approach to improve the delimitation of gene features from RNA-seq data in the chicken model
    Mickael Orgeur, Marvin Martens, Stefan T. Börno, Bernd Timmermann, Delphine Duprez, Sigmar Stricker
    Biology Open 2018 7: bio028498 doi: 10.1242/bio.028498 Published 17 January 2018

    Summary: We combined genome-guided gene prediction and whole transcriptome assembly from RNA sequencing data to improve the chicken genome annotation. This method may be also applicable to other imperfectly annotated genomes.

CORRECTION

  • Open Access
    Correction: The constant threat from a non-native predator increases tail muscle and fast-start swimming performance in Xenopus tadpoles
    Tsukasa Mori, Yukio Yanagisawa, Yoichiro Kitani, Goshi Yamamoto, Naoko Goto-Inoue, Tadashi Kimura, Keiko Kashiwagi, Akihiko Kashiwagi
    Biology Open 2018 7: bio031443 doi: 10.1242/bio.031443 Published 16 January 2018
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  • Open Access

    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
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  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
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  • Open Access

    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
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  • Open Access

    Conditional targeting of phosphatidylserine decarboxylase to lipid droplets

    Santosh Kumar, Chandramohan Chitraju, Robert Farese, Tobias Walther, Christopher G. Burd
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  • Open Access

    The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)

    Kun Guo, Jun Zhong, Lin Zhu, Fan Xie, Yu Du, Xiang Ji
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