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  You have access

  Open access

October, 2018; 7 (10)

RESEARCH ARTICLES

  • Open Access
    A model of mucopolysaccharidosis type IIIB in pigs
    Qiang Yang, Xueyan Zhao, Yuyun Xing, Chao Jiang, Kai Jiang, Pan Xu, Weiwei Liu, Jun Ren, Lusheng Huang
    Biology Open 2018 7: bio035386 doi: 10.1242/bio.035386 Published 26 October 2018

    Summary: We provide a pig model for both genetic and pathological studies of human MPS IIIB, which would contribute to timely diagnoses and better treatments of this rare disease.

  • Open Access
    Hypoxia-ischemia alters distribution of lysosomal proteins in rat cortex and hippocampus
    M. Troncoso, N. Bannoud, L. Carvelli, J. Asensio, A. Seltzer, M. A. Sosa
    Biology Open 2018 7: bio036723 doi: 10.1242/bio.036723 Published 25 October 2018

    Summary: Hypoxia ischemia (HI) induces an increase of gliosis and redistribution of prosaposin and cathepsin D into the cytosol of rat hippocampus. This could be triggered by LAMP-1 cleavage in HI.

  • Open Access
    Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3
    Nicola J. Humphry, Sally P. Wheatley
    Biology Open 2018 7: bio037374 doi: 10.1242/bio.037374 Published 22 October 2018

    Summary: Survivin binds to LC3 through a canonical LIR, yet this interaction is not required for survivin overexpression to reduce autophagic flux, suggesting that survivin regulates autophagy via an alternative mechanism.

  • Open Access
    Plasma membrane damage caused by listeriolysin O is not repaired through endocytosis of the membrane pore
    Lars Nygård Skalman, Mikkel R. Holst, Elin Larsson, Richard Lundmark
    Biology Open 2018 7: bio035287 doi: 10.1242/bio.035287 Published 22 October 2018

    Summary: Using reporter systems and real-time imaging, we show that endocytic pathways are not directly involved in removal of LLO pores from the plasma membrane.

  • Open Access
    Role of water flow regime in the swimming behaviour and escape performance of a schooling fish
    Lauren E. Nadler, Shaun S. Killen, Paolo Domenici, Mark I. McCormick
    Biology Open 2018 7: bio031997 doi: 10.1242/bio.031997 Published 19 October 2018

    Summary: Fish exhibit flow-induced changes in their fast-start escape performance, likely due to an in situ training effect and/or selection for faster performance phenotypes in areas with high flow speed.

  • Open Access
    Hybridization between char species (Salvelinus alpinus and Salvelinus fontinalis): a fast track for novel allometric trajectories
    Bernard-Antonin Dupont Cyr, France Dufresne, Felix Christen, Véronique Desrosiers, Émilie Proulx, Nathalie R. Le François, Grant W. Vandenberg, Pierre U. Blier
    Biology Open 2018 7: bio033332 doi: 10.1242/bio.033332 Published 19 October 2018

    Summary: This research provides a comprehensive overview of the phenotypic modifications in growth trajectories of body size and internal organs following interspecific hybridization in chars.

  • Open Access
    Chromosomal instability causes sensitivity to protein folding stress and ATP depletion
    Mahwish Khan, Zeeshan Shaukat, Robert Saint, Stephen L. Gregory
    Biology Open 2018 7: bio038000 doi: 10.1242/bio.038000 Published 16 October 2018

    Summary: Cells that gain or lose chromosomes during cell division are shown to be sensitive to ATP levels and protein folding stress.

  • Open Access
    Red cell distribution width as a predictor of multiple organ dysfunction syndrome in patients undergoing heart valve surgery
    Piotr Duchnowski, Tomasz Hryniewiecki, Mariusz Kuśmierczyk, Piotr Szymanski
    Biology Open 2018 7: bio036251 doi: 10.1242/bio.036251 Published 16 October 2018

    Summary: This is a single-centre study with a limited number of patients. The results of our research may be helpful in the perioperative strategy in patients undergoing heart valve surgery.

  • Open Access
    A critical period of susceptibility to sound in the sensory cells of cephalopod hatchlings.
    Marta Solé, Marc Lenoir, José-Manuel Fortuño, Mike van der Schaar, Michel André
    Biology Open 2018 7: bio033860 doi: 10.1242/bio.033860 Published 9 October 2018

    Summary: We provide evidence of acoustic trauma in cephalopod hatchling sensory cells after sound exposure, whose damage increases faster than in adults, suggesting a critical period of sensitivity to anthropogenic noise in early stages.

  • Open Access
    Novel phosphorylation states of the yeast spindle pole body
    Kimberly K. Fong, Alex Zelter, Beth Graczyk, Jill M. Hoyt, Michael Riffle, Richard Johnson, Michael J. MacCoss, Trisha N. Davis
    Biology Open 2018 7: bio033647 doi: 10.1242/bio.033647 Published 8 October 2018

    Summary: A phosphoproteome of yeast spindle pole bodies in G1/S or M phase identifies phosphorylation sites involved in spindle length control and provides direction for future phosphorylation analyses of spindle pole components.

  • Open Access
    Bees with attitude: the effects of directed gusts on flight trajectories
    Timothy Jakobi, Dmitry Kolomenskiy, Teruaki Ikeda, Simon Watkins, Alex Fisher, Hao Liu, Sridhar Ravi
    Biology Open 2018 7: bio034074 doi: 10.1242/bio.034074 Published 8 October 2018

    Summary: The effect of atmospheric gusts on the flight trajectories of bumblebees, reporting motion of flight influenced by gusts along with flapping-enabled control strategies that could be necessary elements of flight at this scale.

  • Open Access
    Epigenetic modifications by polyphenolic compounds alter gene expression in the hippocampus
    Tal Frolinger, Francis Herman, Ali Sharma, Steven Sims, Jun Wang, Giulio Maria Pasinetti
    Biology Open 2018 7: bio035196 doi: 10.1242/bio.035196 Published 4 October 2018

    Summary: The health benefits of dietary polyphenols may be due to their ability to change epigenetic marks in the brain. More studies will clarify how polyphenols from diet can improve mental health.

  • Open Access
    Reduction of X-ray-induced DNA damage in normal human cells treated with the PrC-210 radioprotector
    Michael Brand, Matthias Sommer, Frank Jermusek, William E. Fahl, Michael Uder
    Biology Open 2018 7: bio035113 doi: 10.1242/bio.035113 Published 4 October 2018

    Summary: A new strategy is decribed, using a new radioprotector (PrC-210) to significantly reduce radiation-induced DNA damage.

  • Open Access
    The RECK tumor-suppressor protein binds and stabilizes ADAMTS10
    Tomoko Matsuzaki, Hitoshi Kitayama, Akira Omura, Emi Nishimoto, David B. Alexander, Makoto Noda
    Biology Open 2018 7: bio033985 doi: 10.1242/bio.033985 Published 4 October 2018

    Summary: RECK plays critical roles in tumor suppression and embryogenesis, while its mechanisms of actions remain largely obscure. This study has revealed the novel interaction between RECK and ADAMTS10.

  • Open Access
    Ubiquitin A-52 residue ribosomal protein fusion product 1 (Uba52) is essential for preimplantation embryo development
    Jiude Mao, Chad O'Gorman, Miriam Sutovsky, Michal Zigo, Kevin D. Wells, Peter Sutovsky
    Biology Open 2018 7: bio035717 doi: 10.1242/bio.035717 Published 2 October 2018

    Summary: Ubiquitin A-52 residue ribosomal protein fusion product 1 (Uba52), a ubiquitin-ribosomal fusion gene, is a major source of ubiquitin protein for covalent modification of proteinaceous substrates recycled by ubiquitin-proteasome system. Using CRISPR/cas9 gene editing tool, we demonstrate that that Uba52 gene is essential in early embryogenesis in mammals.

METHODS & TECHNIQUES

  • Open Access
    Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease
    Jamie R. Acosta, Maxinne Watchon, Kristy C. Yuan, Jennifer A. Fifita, Adam J. Svahn, Emily K. Don, Claire G. Winnick, Ian P. Blair, Garth A. Nicholson, Nicholas J. Cole, Claire Goldsbury, Angela S. Laird
    Biology Open 2018 7: bio036475 doi: 10.1242/bio.036475 Published 16 October 2018

    Summary: This article describes the optimization and validation of a protocol for culturing of neurons from transgenic zebrafish for the study of neurodegenerative diseases.

  • Open Access
    I spy with my little eye: a simple behavioral assay to test color sensitivity on digital displays
    Alexander G. Knorr, Céline M. Gravot, Clayton Gordy, Stefan Glasauer, Hans Straka
    Biology Open 2018 7: bio035725 doi: 10.1242/bio.035725 Published 5 October 2018

    Summary: We present a simple method to estimate an animals’ sensitivity to component colors of RGB images based on visuo-motor reflexes and demonstrate its applicability in Xenopus laevis and Ambystoma mexicanum.

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    Integrated Analysis of Cell Shape and Movement in Moving Frame

    Yusri Dwi Heryanto, Chin-Yi Cheng, Yutaka Uchida, Kazushi Mimura, Masaru Ishii, Ryo Yamada
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  • Open Access

    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
    PDF
  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
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  • Open Access

    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
    PDF
  • Open Access

    The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)

    Kun Guo, Jun Zhong, Lin Zhu, Fan Xie, Yu Du, Xiang Ji
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