RESEARCH ARTICLES
- A model of mucopolysaccharidosis type IIIB in pigs
Summary: We provide a pig model for both genetic and pathological studies of human MPS IIIB, which would contribute to timely diagnoses and better treatments of this rare disease.
- Hypoxia-ischemia alters distribution of lysosomal proteins in rat cortex and hippocampus
Summary: Hypoxia ischemia (HI) induces an increase of gliosis and redistribution of prosaposin and cathepsin D into the cytosol of rat hippocampus. This could be triggered by LAMP-1 cleavage in HI.
- Survivin inhibits excessive autophagy in cancer cells but does so independently of its interaction with LC3
Summary: Survivin binds to LC3 through a canonical LIR, yet this interaction is not required for survivin overexpression to reduce autophagic flux, suggesting that survivin regulates autophagy via an alternative mechanism.
- Plasma membrane damage caused by listeriolysin O is not repaired through endocytosis of the membrane pore
Summary: Using reporter systems and real-time imaging, we show that endocytic pathways are not directly involved in removal of LLO pores from the plasma membrane.
- Role of water flow regime in the swimming behaviour and escape performance of a schooling fish
Summary: Fish exhibit flow-induced changes in their fast-start escape performance, likely due to an in situ training effect and/or selection for faster performance phenotypes in areas with high flow speed.
- Hybridization between char species (Salvelinus alpinus and Salvelinus fontinalis): a fast track for novel allometric trajectories
Summary: This research provides a comprehensive overview of the phenotypic modifications in growth trajectories of body size and internal organs following interspecific hybridization in chars.
- Chromosomal instability causes sensitivity to protein folding stress and ATP depletion
Summary: Cells that gain or lose chromosomes during cell division are shown to be sensitive to ATP levels and protein folding stress.
- Red cell distribution width as a predictor of multiple organ dysfunction syndrome in patients undergoing heart valve surgery
Summary: This is a single-centre study with a limited number of patients. The results of our research may be helpful in the perioperative strategy in patients undergoing heart valve surgery.
- A critical period of susceptibility to sound in the sensory cells of cephalopod hatchlings.
Summary: We provide evidence of acoustic trauma in cephalopod hatchling sensory cells after sound exposure, whose damage increases faster than in adults, suggesting a critical period of sensitivity to anthropogenic noise in early stages.
- Novel phosphorylation states of the yeast spindle pole body
Summary: A phosphoproteome of yeast spindle pole bodies in G1/S or M phase identifies phosphorylation sites involved in spindle length control and provides direction for future phosphorylation analyses of spindle pole components.
- Bees with attitude: the effects of directed gusts on flight trajectories
Summary: The effect of atmospheric gusts on the flight trajectories of bumblebees, reporting motion of flight influenced by gusts along with flapping-enabled control strategies that could be necessary elements of flight at this scale.
- Epigenetic modifications by polyphenolic compounds alter gene expression in the hippocampus
Summary: The health benefits of dietary polyphenols may be due to their ability to change epigenetic marks in the brain. More studies will clarify how polyphenols from diet can improve mental health.
- Reduction of X-ray-induced DNA damage in normal human cells treated with the PrC-210 radioprotector
Summary: A new strategy is decribed, using a new radioprotector (PrC-210) to significantly reduce radiation-induced DNA damage.
- The RECK tumor-suppressor protein binds and stabilizes ADAMTS10
Summary: RECK plays critical roles in tumor suppression and embryogenesis, while its mechanisms of actions remain largely obscure. This study has revealed the novel interaction between RECK and ADAMTS10.
- Ubiquitin A-52 residue ribosomal protein fusion product 1 (Uba52) is essential for preimplantation embryo development
Summary: Ubiquitin A-52 residue ribosomal protein fusion product 1 (Uba52), a ubiquitin-ribosomal fusion gene, is a major source of ubiquitin protein for covalent modification of proteinaceous substrates recycled by ubiquitin-proteasome system. Using CRISPR/cas9 gene editing tool, we demonstrate that that Uba52 gene is essential in early embryogenesis in mammals.
METHODS & TECHNIQUES
- Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease
Summary: This article describes the optimization and validation of a protocol for culturing of neurons from transgenic zebrafish for the study of neurodegenerative diseases.
- I spy with my little eye: a simple behavioral assay to test color sensitivity on digital displays
Summary: We present a simple method to estimate an animals’ sensitivity to component colors of RGB images based on visuo-motor reflexes and demonstrate its applicability in Xenopus laevis and Ambystoma mexicanum.
This issue
Other journals from The Company of Biologists
Biology Open and COVID-19
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.
Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.
Interview – Savant Thakur
Savant Thakur was a Ph.D. student in Professor Gordon S. Lynch’s lab (The University of Melbourne) working towards understanding the mechanisms of defective muscle repair in muscle diseases and wasting disorders. Sadly, Savant passed away on June 16, 2019 and so one of his supervisors, Professor Lynch, spoke to BiO about Savant's work and character.
A day in the life of a returning spider lab
Back in 2016, two PhD students in Alistair McGregor’s lab at Oxford Brookes shared a day in the life of a spider lab on the Node. Four years and one pandemic later, we caught up with Alistair to find out how his lab has responded to the ongoing Covid-19 crisis.