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  Open access

November, 2018; 7 (11)

RESEARCH ARTICLES

  • Open Access
    Plag1 and Plagl2 have overlapping and distinct functions in telencephalic development
    Lata Adnani, Rajiv Dixit, Xingyu Chen, Anjali Balakrishnan, Harshil Modi, Yacine Touahri, Cairine Logan, Carol Schuurmans
    Biology Open 2018 7: bio038661 doi: 10.1242/bio.038661 Published 26 November 2018

    Summary: Plag1 and Plagl2 are proto-oncogenes that have been studied extensively in cancer. Here we provide the first report of a role for these genes in the developing central nervous system.

  • Open Access
    Effects of drought stress on photosynthesis and photosynthetic electron transport chain in young apple tree leaves
    Zhibo Wang, Guofang Li, Hanqing Sun, Li Ma, Yanping Guo, Zhengyang Zhao, Hua Gao, Lixin Mei
    Biology Open 2018 7: bio035279 doi: 10.1242/bio.035279 Published 22 November 2018

    Summary: This research reports that drought-induced photosynthesis declines due to stomatal and non-stomatal limitation, which was PSII photoinhibition-dependent on D1 protein and over-reduces the electron transport chain.

  • Open Access
    Assessment of high-fat-diet-induced fatty liver in medaka
    Koichi Fujisawa, Taro Takami, Yumi Fukui, Takahiro Nagatomo, Issei Saeki, Toshihiko Matsumoto, Isao Hidaka, Naoki Yamamoto, Takeshi Okamoto, Makoto Furutani-Seiki, Isao Sakaida
    Biology Open 2018 7: bio031534 doi: 10.1242/bio.031534 Published 22 November 2018

    Summary: Our medaka model allows for non-invasive and repetitive assessment and is useful in the analysis of fatty liver in which changes in detailed metabolites are identified.

  • Open Access
    Differences in the morphology, physiology and gene expression of honey bee queens and workers reared in vitro versus in situ
    Daiana A. De Souza, Osman Kaftanoglu, David De Jong, Robert E. Page, Jr, Gro V. Amdam, Ying Wang
    Biology Open 2018 7: bio036616 doi: 10.1242/bio.036616 Published 22 November 2018

    Summary: We used in vitro-rearing methodology to investigate how differences in rearing conditions, including nutrition, affect the morphology, metabolic physiology and gene expression of honey bee queens and workers.

  • Open Access
    PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA
    Ying Liu, Rita Cerejeira Matos, Tapio I. Heino, Ville Hietakangas
    Biology Open 2018 7: bio037911 doi: 10.1242/bio.037911 Published 22 November 2018

    Summary: We report that a chromatin-binding protein PWP1 binds to 5S ribosomal DNA, regulates its epigenetic status and controls nutrient-dependent RNA polymerase III-mediated transcription of 5S ribosomal RNA.

  • Open Access
    Characterization of spatial and temporal development of Type I and Type II hair cells in the mouse utricle using new cell-type-specific markers
    Stephen McInturff, Joseph C. Burns, Matthew W. Kelley
    Biology Open 2018 7: bio038083 doi: 10.1242/bio.038083 Published 19 November 2018

    Summary: Single cell RNAseq was used to identify new markers for specific hair cell in the mammalian utricle. With these new markers, the developmental timing of specific types of hair cells was examined.

  • Open Access
    The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts
    Vedad Delic, Kenyaria Noble, Sandra Zivkovic, Tam-Anh Phan, Christian Reynes, Yumeng Zhang, Oluwakemi Phillips, Charles Claybaker, Yen Ta, Vinh B. Dinh, Josean Cruz, Tomas A. Prolla, Patrick C. Bradshaw
    Biology Open 2018 7: bio033852 doi: 10.1242/bio.033852 Published 16 November 2018

    Summary: A novel mitochondrial DNA mutator murine embryonic fibroblast cell line was created and the effects of the anti-aging compounds rapamycin and AICAR on energy metabolism in these cells was determined.

  • Open Access
    Long non-coding RNA PICSAR decreases adhesion and promotes migration of squamous carcinoma cells by downregulating α2β1 and α5β1 integrin expression
    Minna Piipponen, Jyrki Heino, Veli-Matti Kähäri, Liisa Nissinen
    Biology Open 2018 7: bio037044 doi: 10.1242/bio.037044 Published 14 November 2018

    Summary: Long non-coding RNA PICSAR decreases adhesion and promotes migration of cutaneous squamous cell carcinoma cells by regulating the expression of collagen and fibronectin binding α2β1 and α5β1 integrins.

  • Open Access
    The mechanistic insight of a specific interaction between 15d-Prostaglandin-J2 and eIF4A suggests an evolutionary conserved role across species
    So Jeong Yun, Hyunjoon Kim, Seung-Hyun Jung, Joon Hyun Kim, Jeong Eun Ryu, N. Jiten Singh, Jouhyun Jeon, Jin-Kwan Han, Cheol-Hee Kim, Sanguk Kim, Sung Key Jang, Woo Jae Kim
    Biology Open 2018 7: bio035402 doi: 10.1242/bio.035402 Published 13 November 2018

    Summary: The tail region of 15d-PGJ2 plays a important role in modulating the activity of eIF4A protein across species. This implies that the tail region of this prostaglandins can be adapted to design new drugs.

  • Open Access
    Evolution and multiple origins of zona pellucida genes in vertebrates
    Jin-Mei Feng, Hai-Feng Tian, Qiao-Mu Hu, Yan Meng, Han-Bing Xiao
    Biology Open 2018 7: bio036137 doi: 10.1242/bio.036137 Published 13 November 2018

    Summary: Phylogenetic and synteny analyses indicate that the vertebrate zona pellucida (ZP) genes encoding egg coat proteins can be classified into eight subfamilies, and the evolutionary origins of these genes are discussed.

  • Open Access
    Basal constriction during midbrain–hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase
    Jennifer H. Gutzman, Ellie Graeden, Isabel Brachmann, Sayumi Yamazoe, James K. Chen, Hazel Sive
    Biology Open 2018 7: bio034520 doi: 10.1242/bio.034520 Published 13 November 2018

    Summary: Focal adhesion kinase acts downstream of Wnt5b to mediate basal constriction of neuroepithelial cells during the formation of the midbrain–hindbrain boundary.

  • Open Access
    Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice
    Xinyi Mu, Jia Wen, Qian Chen, Zhengpin Wang, Yijing Wang, Meng Guo, Yi Yang, JinRui Xu, Zhiqing Wei, Guoliang Xia, Mengye Yang, Chao Wang
    Biology Open 2018 7: bio035626 doi: 10.1242/bio.035626 Published 12 November 2018

    Summary: CYP51 displays cytoplasm-to-nucleus translocation in germ cells in mice. CYP51 participates in germ cell meiotic progression and folliculogenesis via regulating the expression of cohesin REC8 and STAG3.

  • Open Access
    Comparison of circulating metabolite concentrations in dogs and cats when allowed to freely choose macronutrient intake
    Jean A. Hall, Matthew I. Jackson, Jodi C. Vondran, Melissa A. Vanchina, Dennis E. Jewell
    Biology Open 2018 7: bio036228 doi: 10.1242/bio.036228 Published 2 November 2018

    Summary: Dogs and cats offered foods with different macronutrient composition, but equivalent palatability, have different circulating metabolite concentrations that reflect differences in species and food choices.

  • Open Access
    Drosophila Ror is a nervous system-specific co-receptor for Wnt ligands
    Caroline Ripp, Julia Loth, Iveta Petrova, Karen Linnemannstöns, Monique Ulepic, Lee Fradkin, Jasprien Noordermeer, Andreas Wodarz
    Biology Open 2018 7: bio033001 doi: 10.1242/bio.033001 Published 2 November 2018

    Summary: Drosophila Ror is a Wnt co-receptor expressed in the nervous system. A Ror null mutant allele is viable and shows genetic interaction with mutations in off-track and off-track2.

  • Open Access
    The role of integrin β1 in the heterogeneity of human embryonic stem cells culture
    Ade Kallas-Kivi, Annika Trei, Artjom Stepanjuk, Katrin Ruisu, Keiu Kask, Margus Pooga, Toivo Maimets
    Biology Open 2018 7: bio034355 doi: 10.1242/bio.034355 Published 1 November 2018

    Summary: The interaction between integrin β1 and the extracellular matrix differs at the centre of the colony and at the periphery, and is crucial for the survival of embryonic stem cells.

  • Open Access
    Involvement of sulfated biopolymers in adhesive secretions produced by marine invertebrates
    Elise Hennebert, Edwicka Gregorowicz, Patrick Flammang
    Biology Open 2018 7: bio037358 doi: 10.1242/bio.037358 Published 31 October 2018

    Summary: Sulfate groups borne by adhesive macromolecules play a role in attachment to underwater surfaces in marine invertebrates using non-permanent adhesion, but not in those using permanent or instantaneous adhesion.

  • Open Access
    Characterisation of maturation of photoreceptor cell subtypes during zebrafish retinal development
    Cátia Crespo, Elisabeth Knust
    Biology Open 2018 7: bio036632 doi: 10.1242/bio.036632 Published 31 October 2018

    Summary: We characterised subtype-specific growth of the different photoreceptor compartments, organelle distribution and the influence of light on the growth of the apical membrane.

METHODS AND TECHNIQUES

  • Open Access
    A sample preparation workflow for adipose tissue shotgun proteomics and proteogenomics
    Jane I. Khudyakov, Jared S. Deyarmin, Ryan M. Hekman, Laura Pujade Busqueta, Rasool Maan, Melony J. Mody, Reeti Banerjee, Daniel E. Crocker, Cory D. Champagne
    Biology Open 2018 7: bio036731 doi: 10.1242/bio.036731 Published 19 November 2018

    Summary: Proteins that are compatible with shotgun proteomics can be isolated from small amounts of adipose tissue at the same time as RNA, facilitating proteogenomics studies in non-model animals.

  • Open Access
    DARPins recognizing mTFP1 as novel reagents for in vitro and in vivo protein manipulations
    M. Alessandra Vigano, Dimitri Bieli, Jonas V. Schaefer, Roman P. Jakob, Shinya Matsuda, Timm Maier, Andreas Plückthun, Markus Affolter
    Biology Open 2018 7: bio036749 doi: 10.1242/bio.036749 Published 29 October 2018

    Summary: Structural characterization of two novel DARPins (designed ankyrin repeat proteins) recognizing the monomeric teal fluorescent protein 1 (mTFP1) and their functionalization for protein manipulation strategies in cultured cells and potentially in living organisms.

FIRST PERSON

  • Open Access
    First person – Lata Adnani
    Biology Open 2018 7: bio039610 doi: 10.1242/bio.039610 Published 26 November 2018
  • Open Access
    First person – Daiana Almeida De Souza
    Biology Open 2018 7: bio039313 doi: 10.1242/bio.039313 Published 22 November 2018
  • Open Access
    First person – Ying Liu
    Biology Open 2018 7: bio039636 doi: 10.1242/bio.039636 Published 22 November 2018
  • Open Access
    First person – Jane Khudyakov
    Biology Open 2018 7: bio039321 doi: 10.1242/bio.039321 Published 19 November 2018
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Biology Open: 7 (11)
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  • Open Access

    Notch signaling governs the expression of glypican Dally to define the stem cell niche

    Songhua Zhao, Chan Wu, Zhiyang Gao, Xin Li, Guo Zheng, Zhaohui Wang
    PDF
  • Open Access

    Visualisation of ribosomes in Drosophila axons using Ribo-BiFC

    Anand K. Singh, Akilu Abdullahi, Matthias Soller, Alexandre David, Saverio Brogna
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  • Open Access

    Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease

    Juan Garrido-Maraver, Samantha H. Y. Loh, L. Miguel Martins
    PDF
  • Open Access

    Larval mannitol diets increase mortality, prolong development, and decrease adult body sizes in fruit flies (Drosophila melanogaster)

    Meghan Barrett, Katherine Fiocca, Edward A. Waddell, Cheyenne McNair, Sean O'Donnell, Daniel R. Marenda
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  • Open Access

    The interconnection between cytokeratin and cell membrane-bound β-catenin in Sertoli cells derived from juvenile Xenopus tropicalis testes

    Thi Minh Xuan Nguyen, Marketa Vegrichtova, Tereza Tlapakova, Magdalena Krulova, Vladimir Krylov
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