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Research Article
PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA
Ying Liu, Rita Cerejeira Matos, Tapio I. Heino, Ville Hietakangas
Biology Open 2018 7: bio037911 doi: 10.1242/bio.037911 Published 22 November 2018
Ying Liu
1Faculty of Biological and Environmental Sciences, University of Helsinki, 00790 Helsinki, Finland
2Institute of Biotechnology, University of Helsinki, 00790 Helsinki, Finland
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Rita Cerejeira Matos
1Faculty of Biological and Environmental Sciences, University of Helsinki, 00790 Helsinki, Finland
2Institute of Biotechnology, University of Helsinki, 00790 Helsinki, Finland
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Tapio I. Heino
1Faculty of Biological and Environmental Sciences, University of Helsinki, 00790 Helsinki, Finland
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Ville Hietakangas
1Faculty of Biological and Environmental Sciences, University of Helsinki, 00790 Helsinki, Finland
2Institute of Biotechnology, University of Helsinki, 00790 Helsinki, Finland
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  • ORCID record for Ville Hietakangas
  • For correspondence: ville.hietakangas@helsinki.fi
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ABSTRACT

PWP1 is a chromatin binding protein with an important role in animal growth control downstream of mTOR-mediated nutrient sensing. PWP1 has been shown to control tissue growth by promoting the transcription of 5.8S, 18S and 28S ribosomal RNAs (rRNAs) by RNA polymerase I (Pol I). Concomitantly with Pol I, RNA Polymerase III (Pol III) contributes to ribosome biogenesis by transcribing 5S rRNA in the nucleoplasm. Pol III activity is also closely controlled by nutrient-dependent signaling, however, how the activities of Pol I and Pol III are coordinated in response to nutrient-derived signals remains insufficiently understood. Experiments in Drosophila larvae and human cells reported here show that PWP1 associates with the chromatin at the 5S rDNA loci and is needed for nutrient-induced expression of 5S rRNA. Similar to the Pol I target rDNAs, PWP1 epigenetically maintains 5S rDNA in a transcription competent state. Thus, as a common regulator of Pol I and Pol III, PWP1 might contribute to coordinated control of ribosomal gene expression in response to nutrition.

This article has an associated First Person interview with the first author of the paper.

Footnotes

  • Competing interests

    The authors declare no competing or financial interests.

  • Author contributions

    Conceptualization: Y.L., V.H.; Methodology: Y.L., R.C.M., T.I.H.; Validation: Y.L., R.C.M.; Formal analysis: Y.L., R.C.M.; Investigation: Y.L., R.C.M.; Writing - original draft: Y.L., R.C.M., V.H.; Writing - review & editing: T.I.H.; Visualization: R.C.M.; Supervision: T.I.H., V.H.; Project administration: V.H.; Funding acquisition: V.H.

  • Funding

    This study was supported by the Academy of Finland [286767], Sigrid Juselius Foundation and Novo Nordisk Foundation [NNF16OC0021460].

  • Supplementary information

    Supplementary information available online at http://bio.biologists.org/lookup/doi/10.1242/bio.037911.supplemental

  • Received August 20, 2018.
  • Accepted October 3, 2018.
  • © 2018. Published by The Company of Biologists Ltd
http://creativecommons.org/licenses/by/4.0

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Keywords

  • PWP1
  • NCLB
  • Nutrient
  • 5S ribosomal RNA
  • Transcription
  • RNA polymerase III

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Research Article
PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA
Ying Liu, Rita Cerejeira Matos, Tapio I. Heino, Ville Hietakangas
Biology Open 2018 7: bio037911 doi: 10.1242/bio.037911 Published 22 November 2018
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Research Article
PWP1 promotes nutrient-responsive expression of 5S ribosomal RNA
Ying Liu, Rita Cerejeira Matos, Tapio I. Heino, Ville Hietakangas
Biology Open 2018 7: bio037911 doi: 10.1242/bio.037911 Published 22 November 2018

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