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  You have access

  Open access

December, 2018; 7 (12)

RESEARCH ARTICLES

  • Open Access
    Endodermal pouch-expressed dmrt2b is important for pharyngeal cartilage formation
    Linwei Li, Aihua Mao, Peng Wang, Guozhu Ning, Yu Cao, Qiang Wang
    Biology Open 2018 7: bio035444 doi: 10.1242/bio.035444 Published 17 December 2018

    Summary: Transcription factor dmrt2b facilitates cxcl12b expression in endodermal pouches to accelerate cranial neural crest cell condensation, but suppresses crossveinless 2 expression for supporting cell growth and chondrogenic differentiation.

  • Open Access
    Human asparagine synthetase associates with the mitotic spindle
    Chalongrat Noree, Elena Monfort, Vorasuk Shotelersuk
    Biology Open 2018 7: bio038307 doi: 10.1242/bio.038307 Published 14 December 2018

    Summary: While yeast Asn1p/ASN2p forms cytoplasmic filaments in response to nutrient limitation, hASNS is associated with centrosomes and mitotic spindles in actively dividing cells, suggesting its additional role in cell division.

  • Open Access
    Potassium fertilization arrests malate accumulation and alters soluble sugar metabolism in apple fruit
    Wen Zhang, Xian Zhang, Yufei Wang, Nishang Zhang, Yanping Guo, Xiaolin Ren, Zhengyang Zhao
    Biology Open 2018 7: bio024745 doi: 10.1242/bio.024745 Published 14 December 2018

    Summary: Optimized potassium levels not only reduce malate levels but also improve fructose and sucrose accumulation in apple fruit.

  • Open Access
    Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5
    Qingya Shen, Zhiyu Qiu, Wenping Wu, Jimin Zheng, Zongchao Jia
    Biology Open 2018 7: bio037366 doi: 10.1242/bio.037366 Published 14 December 2018

    Summary: Identification of the recruit function of the N-terminal lobe of the UBR5 HECT domain and ubiquitination site(s) of PEPCK1.

  • Open Access
    Dynamic microtubules drive fibroblast spreading
    Anna Tvorogova, Aleena Saidova, Tatiana Smirnova, Ivan Vorobjev
    Biology Open 2018 7: bio038968 doi: 10.1242/bio.038968 Published 13 December 2018

    Summary: Cell spreading is a non-linear process. The fast spreading phase depends on dynamic microtubules (MTs). Rapid growth of MTs towards the cell membrane promotes the temporal relaxation of acto-myosin contractility.

  • Open Access
    Effect of temperature change on synaptic transmission at crayfish neuromuscular junctions
    Yuechen Zhu, Leo de Castro, Robin Lewis Cooper
    Biology Open 2018 7: bio037820 doi: 10.1242/bio.037820 Published 12 December 2018

    Summary: Studies were conducted in the model invertebrate, the crayfish, to determine the effects of the acute change from 20°C to 10°C and vice versa on synaptic transmission.

  • Open Access
    Low cholesterol is not always good: low cholesterol levels are associated with decreased serotonin and increased aggression in fish
    Ariane Aguiar, Percília Cardoso Giaquinto
    Biology Open 2018 7: bio030981 doi: 10.1242/bio.030981 Published 10 December 2018

    Summary: Fish treated with statin exhibited reduced plasma cholesterol, reduced telencephalic indexes of 5-HIAA/5-HT and increased aggressive behavior compared with control fish. Such mechanisms may be important for the control of aggression in many vertebrate species.

  • Open Access
    Monitoring and evaluation of the immune status of female Kunming mice maintained in different biosafety level laboratories
    Lei Guo, Yuan He, Heng Li, Yong Chen, Fanli Zhu, Mengli Yang, Chengyun Yang, Qing Dai, Haijing Shi, Longding Liu
    Biology Open 2018 7: bio035006 doi: 10.1242/bio.035006 Published 10 December 2018

    Summary: Mice maintained in ABSL-3 and ABSL-4 labs are under normal and stable physiology and immune status.

  • Open Access
    A Gata4 nuclear GFP transcriptional reporter to study endoderm and cardiac development in the mouse
    Claire S. Simon, Lu Zhang, Tao Wu, Weibin Cai, Nestor Saiz, Sonja Nowotschin, Chen-Leng Cai, Anna-Katerina Hadjantonakis
    Biology Open 2018 7: bio036517 doi: 10.1242/bio.036517 Published 10 December 2018

    Summary: Generation of a Gata4H2B-GFP reporter mouse that labels primitive endoderm, visceral endoderm and cardiac lineages during embryonic development suitable for single cell and live imaging analyses.

  • Open Access
    The role of personality variation, plasticity and social facilitation in cockroach aggregation
    Isaac Planas-Sitjà, Jean-Louis Deneubourg
    Biology Open 2018 7: bio036582 doi: 10.1242/bio.036582 Published 10 December 2018

    Summary: We used the American cockroach to show that individuals displaying low behavioural plasticity entrain the behaviour of other individuals through social interactions and change the aggregation dynamics of the group.

  • Open Access
    Neural activation following offensive aggression in Japanese quail
    Cornelia Voigt, Katharina Hirschenhauser, Stefan Leitner
    Biology Open 2018 7: bio038026 doi: 10.1242/bio.038026 Published 10 December 2018

    Summary: The manuscript describes the pronounced activation of the immediate early gene ZENK in the pallium of male Japanese quails following offensive aggressive behaviour.

  • Open Access
    Seasonal variations in cellular and humoral immunity in male striped hamsters (Cricetulus barabensis)
    De-Li Xu, Xiao-Kai Hu, Yufen Tian
    Biology Open 2018 7: bio038489 doi: 10.1242/bio.038489 Published 10 December 2018

    Summary: Seasonal changes in immunity, body fat, blood glucose, leptin and corticosterone and their correlations in striped hamsters.

  • Open Access
    Promoter-enhancer looping and shadow enhancers of the mouse αA-crystallin locus
    Rebecca S. McGreal-Estrada, Louise V. Wolf, Ales Cvekl
    Biology Open 2018 7: bio036897 doi: 10.1242/bio.036897 Published 7 December 2018

    Summary: The αA-crystallin ranks amongst the most highly expressed tissue-specific genes. It is an advantageous model system to probe both promoter-enhancer looping and to identify distal enhancers and their temporal/spatial activities.

  • Open Access
    IRS-1 increases TAZ expression and promotes osteogenic differentiation in rat bone marrow mesenchymal stem cells
    Na Wang, Peng Xue, Ziyi Li, Yukun Li
    Biology Open 2018 7: bio036194 doi: 10.1242/bio.036194 Published 7 December 2018

    Summary: Stem cell therapy has become a promising approach for bone tissue engineering. Our study reveals that IRS-1 gene modification of stem cells upregulates TAZ expression and osteogenesis.

  • Open Access
    Live imaging of cortical granule exocytosis reveals that in vitro matured mouse oocytes are not fully competent to secrete their content
    Andrea I. Cappa, Matilde de Paola, Paula Wetten, Gerardo A. De Blas, Marcela A. Michaut
    Biology Open 2018 7: bio031872 doi: 10.1242/bio.031872 Published 3 December 2018

    Summary: Live imaging of cortical granule exocytosis reveals that in vitro matured mouse oocytes have a severely reduced response to strontium chloride.

  • Open Access
    Auditory perception exhibits sexual dimorphism and left telencephalic dominance in Xenopus laevis
    Yanzhu Fan, Xizi Yue, Fei Xue, Jianguo Cui, Steven E. Brauth, Yezhong Tang, Guangzhan Fang
    Biology Open 2018 7: bio035956 doi: 10.1242/bio.035956 Published 3 December 2018

    Summary: Investigation of auditory neural mechanisms in the South African clawed frog (Xenopus laevis) indicates that auditory perception exhibits sexual dimorphism and left telencephalic advantage.

  • Open Access
    Short-term cortisol exposure alters cardiac hypertrophic and non-hypertrophic signalling in a time-dependent manner in rainbow trout
    Karoline S. Nørstrud, Marco A. Vindas, Göran E. Nilsson, Ida B. Johansen
    Biology Open 2018 7: bio037853 doi: 10.1242/bio.037853 Published 29 November 2018

    Summary: Here we indicate that short-term cortisol exposure can induce cardiac hypertrophic and non-hypertrophic remodelling and that certain pro-hypertrophic effects of cortisol are time-dependent in rainbow trout.

  • Open Access
    Daily changes in the electric behavior of weakly electric fish naturally persist in constant darkness and are socially synchronized
    Adriana Migliaro, Victoria Moreno, Paul Marchal, Ana Silva
    Biology Open 2018 7: bio036319 doi: 10.1242/bio.036319 Published 29 November 2018

    Summary: The nocturnal increase of electric behavior in Gymnotus omarorum is analyzed in the wild, in constant darkness and social isolation. This daily trait is independent of locomotor activity and modulated by social context.

  • Open Access
    Characterization and in ovo vascularization of a 3D-printed hydroxyapatite scaffold with different extracellular matrix coatings under perfusion culture
    Floriana Burgio, Natalie Rimmer, Uwe Pieles, Johanna Buschmann, Marina Beaufils-Hugot
    Biology Open 2018 7: bio034488 doi: 10.1242/bio.034488 Published 26 November 2018

    Summary: Depending on the culture media, ECM coating of 3D-printed hydroxyapatite evokes different functional vascularization as assessed by CAM assay in ovo. ECM coating enhances vascularization compared to ECM-free hydroxyapatite.

METHODS & TECHNIQUES

  • Open Access
    An in vivo translation-reporter system for the study of protein synthesis in zebrafish embryos
    Inês Garcez Palha, Isabelle Anselme, Sylvie Schneider-Maunoury, François Giudicelli
    Biology Open 2018 7: bio039362 doi: 10.1242/bio.039362 Published 13 December 2018

    Summary: We describe a transgene-based method, SPoT, that reveals subcellular sites of protein synthesis in neurons of wholemount zebrafish embryos.

  • Open Access
    Model-based serial blood sampling protocol for minimal mortality and better recovery in small to medium sized tilapia
    Chris Sihoka, Ina Wagenaar
    Biology Open 2018 7: bio037978 doi: 10.1242/bio.037978 Published 27 November 2018

    Summary: A model-based repeated blood sampling protocol retained tolerable levels of anaemia, minimised mortality, assured recovery and made repeated blood sampling feasible in small to medium sized tilapia.

FIRST PERSON

  • Open Access
    First person – De-Li Xu
    Biology Open 2018 7: bio039685 doi: 10.1242/bio.039685 Published 10 December 2018
  • Open Access
    First person – Claire Simon
    Biology Open 2018 7: bio040105 doi: 10.1242/bio.040105 Published 10 December 2018
  • Open Access
    First person – Andrea Cappa
    Biology Open 2018 7: bio039644 doi: 10.1242/bio.039644 Published 3 December 2018

CORRECTION

  • Open Access
    Correction: DARPins recognizing mTFP1 as novel reagents for in vitro and in vivo protein manipulations (doi:10.1242/bio.036749)
    M. Alessandra Vigano, Dimitri Bieli, Jonas V. Schaefer, Roman P. Jakob, Shinya Matsuda, Timm Maier, Andreas Plückthun, Markus Affolter
    Biology Open 2018 7: bio040832 doi: 10.1242/bio.040832 Published 13 December 2018
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  • Open Access

    Smoking flies: Testing the effect of tobacco cigarettes on heart function of Drosophila melanogaster

    Manuela Santalla, Lucía Pagola, Ivana Gómez, Darío Balcazar, Carlos A. Valverde, Paola Ferrero
    PDF
  • Open Access

    Giraffes and hominins: reductionist model predictions of compressive loads at the spine base for erect exponents of the animal kingdom

    Michael Günther, Falk Mörl
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  • Open Access

    Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry

    Hantian Qiu, Sayaka Fujisawa, Shohei Nozaki, Yohei Katoh, Kazuhisa Nakayama
    PDF
  • Open Access

    A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference

    Nina Graffmann, Audrey Ncube, Soraia Martins, Aurelian Robert Fiszl, Philipp Reuther, Martina Bohndorf, Wasco Wruck, Mathias Beller, Constantin Czekelius, James Adjaye
    PDF
  • Open Access

    A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and notch signaling

    Katherine K. Slemmons, Michael D. Deel, Yi-Tzu Lin, Kristianne M. Oristian, Nina Kuprasertkul, Katia C. Genadry, Po-Han Chen, Jen-Tsan Ashley Chi, Corinne M. Linardic
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