MEETING REVIEW
- Symbiosis in the microbial world: from ecology to genome evolution
Summary: At a recent Company of Biologists workshop, evolutionary biologists discussed the major outstanding questions in symbiosis research.
RESEARCH ARTICLES
- Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice
Summary: S1P governs a fundamental aspect of skeletal development and homeostasis, mainly the maintenance and osteogenic differentiation of skeletogenic stem cells that are a source of osteoblast and chondrocyte lineages.
- Mechanical properties of silk of the Australian golden orb weavers Nephila pilipes and Nephila plumipes
Summary: Spider silk is a remarkably tough and extensible biomaterial. We identified macrostuctural and mechanical differences in outer web frame silk of two Australian orb-weaving spiders.
- Ecdysone signaling regulates specification of neurons with a male-specific neurite in Drosophila
Summary: The insect molting hormone ecdysone determines whether a single neuron develops a sex-specific structure, through crosstalk with signaling elements in a pathway dedicated to the sex-fate determination.
- Timing and context of dolphin clicks during and after mine simulator detection and marking in the open ocean
Summary: Dolphins wore cameras so we could hear them and watch them mark mine simulators. We observed rhythmic click trains, victory squeals, and click packets with their behavioral context.
- The histone deacetylase HDAC1 positively regulates Notch signaling during Drosophila wing development
Summary: The histone deacetylase HDAC1 acts as a positive regulator of Notch signaling during Drosophila wing development, and its depletion causes wing notches on the margin of adult wing.
- Spermine modulates fungal morphogenesis and activates plasma membrane H+-ATPase during yeast to hyphae transition
Summary: This study presents a new mechanistic model for the integrative role of the polyamine spermine and hormone auxin in the signaling of yeast-to-hypha transition, filling an important gap in fungal morphogenesis.
- Metabolism of the Pacific oyster, Crassostrea gigas, is influenced by salinity and modulates survival to the Ostreid herpesvirus OsHV-1
Summary: Environmental salinity influences energetic reserves, enzyme activity, membrane fatty acids of the Pacific oyster and modulates survival to viral infection.
- Sustained exercise-trained juvenile black carp (Mylopharyngodon piceus) at a moderate water velocity exhibit improved aerobic swimming performance and increased postprandial metabolic responses
Summary: Sustained exercise training at a moderate water velocity had positive effects on aerobic swimming performance and postprandial metabolic responses in juvenile black carp (Mylopharyngodon piceus).
- Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice
Summary: We describe a model that recapitulates multiple components of liver damage by HIV-1 infection as in humans, including reduced liver CD4+ cells, albumin levels, liver immune activation and human hepatocyte survival.
- How does the snakehead Channa argus survive in air? The combined roles of the suprabranchial chamber and physiological regulations during aerial respiration
Summary: The aerial survival of the northern snakehead could be involved with suprabranchial chamber respiration, and also with physiological regulations.
- Plastid translation is essential for lateral root stem cell patterning in Arabidopsis thaliana
Summary: Successful plastid gene expression is required for stem cell patterning in lateral root primordia as revealed by genetic and pharmacological impairment of plastid translation.
- A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5
Summary: A novel transgenic zebrafish, using claudin 5a, represents an ideal model to study blood brain barrier and choroid plexus barrier development and function in vivo.
- Gemin4 is an essential gene in mice, and its overexpression in human cells causes relocalization of the SMN complex to the nucleoplasm
Summary: Gemin4 loss-of-function is recessive lethal in mice, whereas in cell culture its overexpression results in a dominant, gain-of-function relocalization of SMN and other Gemin proteins to the nucleus.
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Biology Open and COVID-19
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.
Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.
Virtual events at The Company of Biologists
In September, our sister journal Development held its bi-yearly Journal Meeting. Known for its excellent social opportunities, the Meeting this year was recreated for a virtual format. Participants say it was the most ‘lifelike’ virtual meeting they’ve attended – find out more about how we’re reimagining our events virtually.
Interviews – Tiyasha Sarkar and Komal Panchal
We champion the next generation of biologists and are pleased to give first authors the chance to discuss their research in interviews alongisde their papers. In our latest issue, Tiyasha talks about her work on neurological disorders and Komal discusses her research on Alzheimer’s disease.
Cover article - Cell-to-cell communication mediates glioblastoma progression in Drosophila
Issue 9’s cover is a glioblastoma single brain hemisphere section from Drosophila third-instar larvae, from a study by Portela and colleagues.