Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Interviews
    • Sign up for alerts
  • About us
    • About BiO
    • Editors and Board
    • Editor biographies
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contact
    • Contact BiO
    • Advertising
    • Feedback
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in

Search

  • Advanced search
Biology Open
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Biology Open

Advanced search

RSS   Twitter   Facebook   YouTube

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Interviews
    • Sign up for alerts
  • About us
    • About BiO
    • Editors and Board
    • Editor biographies
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contact
    • Contact BiO
    • Advertising
    • Feedback

 

  You have access

  Open access

March, 2018; 7 (3)

RESEARCH ARTICLES

  • Open Access
    Whole-transcriptome splicing profiling of E7.5 mouse primary germ layers reveals frequent alternative promoter usage during mouse early embryogenesis
    Xukun Lu, Zhen-Ao Zhao, Xiaoqing Wang, Xiaoxin Zhang, Yanhua Zhai, Wenbo Deng, Zhaohong Yi, Lei Li
    Biology Open 2018 7: bio032508 doi: 10.1242/bio.032508 Published 28 March 2018

    Summary: This study seeks to capture the alternative splicing landscape during mouse gastrulation, underlining the potential importance of alternative promoter usage in mammalian early embryogenesis.

  • Open Access
    Separate roles for Med12 and Wnt signaling in regulation of oxytocin expression
    Emma D. Spikol, Eric Glasgow
    Biology Open 2018 7: bio031229 doi: 10.1242/bio.031229 Published 28 March 2018

    Summary: Mediator 12, a transcriptional coactivator, greatly enhances Wnt signaling in the developing embryo. Separate from its role in Wnt signaling, Mediator 12 is required for oxytocin expression.

  • Open Access
    Inhibition of miR-34a-5p alleviates hypoxia-reoxygenation injury by enhancing autophagy in steatotic hepatocytes
    Chuanjiang Li, Kai Wang, Linghong Guo, Hang Sun, Hai Huang, XinXin Lin, Qingping Li
    Biology Open 2018 7: bio033290 doi: 10.1242/bio.033290 Published 26 March 2018

    Summary: Our study establishes an in vitro model for studying H/R injury in fatty liver, and shows that MiR-34a plays an important role in worsening H/R injury, likely by suppressing autophagy in steatotic hepatocytes.

  • Open Access
    Degradation of cyclin B is critical for nuclear division in Trypanosoma brucei
    Hanako Hayashi, Bungo Akiyoshi
    Biology Open 2018 7: bio031609 doi: 10.1242/bio.031609 Published 23 March 2018

    Summary: Trypanosomes do not have a spindle checkpoint but have an ability to regulate the timing of nuclear division by modulating the cyclin B protein level.

  • Open Access
    The cross-tissue metabolic response of abalone (Haliotis midae) to functional hypoxia
    Leonie Venter, Du Toit Loots, Lodewyk J. Mienie, Peet J. Jansen van Rensburg, Shayne Mason, Andre Vosloo, Jeremie Z. Lindeque
    Biology Open 2018 7: bio031070 doi: 10.1242/bio.031070 Published 23 March 2018

    Summary: We report, for the first time, a metabolic map of abalone metabolism in response to functional hypoxia, compiled from results obtained by metabolomics analysis.

  • Open Access
    The teneurin C-terminal domain possesses nuclease activity and is apoptogenic
    Jacqueline Ferralli, Richard P. Tucker, Ruth Chiquet-Ehrismann
    Biology Open 2018 7: bio031765 doi: 10.1242/bio.031765 Published 19 March 2018

    Summary: Teneurins are transmembrane proteins found in the developing nervous system that are related to bacterial toxins. Teneurins also have cytotoxic properties that may help regulate apoptosis or pruning.

  • Open Access
    pH controls spermatozoa motility in the Pacific oyster (Crassostrea gigas)
    Myrina Boulais, Marc Suquet, Eve Julie Arsenault-Pernet, Florent Malo, Isabelle Queau, Patricia Pignet, Dominique Ratiskol, Jacqueline Le Grand, Matthias Huber, Jacky Cosson
    Biology Open 2018 7: bio031427 doi: 10.1242/bio.031427 Published 19 March 2018

    Summary: Oyster sperm motility is not triggered in an acidic environment and motility is controlled by internal pH alkalinization, mediated by a Na+/H+ exchanger.

  • Open Access
    ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest
    Aya Noguchi, Shungo Adachi, Naoto Yokota, Tomohisa Hatta, Tohru Natsume, Hiroyuki Kawahara
    Biology Open 2018 7: bio031575 doi: 10.1242/bio.031575 Published 12 March 2018

    Summary: ZFP36L2 is a cell cycle-regulated RNA-binding protein, the abundance of which is regulated post-translationally. This protein is especially accumulated in and critical for the survival of DNA-damaged cells.

  • Open Access
    Adjustable delivery of pro-angiogenic FGF-2 by alginate:collagen microspheres
    Zaheer Ali, Anik Islam, Peter Sherrell, Mark Le-Moine, Georgios Lolas, Konstantinos Syrigos, Mehrdad Rafat, Lasse D. Jensen
    Biology Open 2018 7: bio027060 doi: 10.1242/bio.027060 Published 12 March 2018

    Summary: The development of alginate:collagen composite hydrogel microspheres of adjustable size and degradation speed is described as a new platform for delivery of pro-angiogenic FGF-2 or pro-angiogenic cells.

  • Open Access
    A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse
    Alexander M. Herman, Alexander M. Rhyner, W. Patrick Devine, Sean P. Marrelli, Benoit G. Bruneau, Joshua D. Wythe
    Biology Open 2018 7: bio026799 doi: 10.1242/bio.026799 Published 12 March 2018

    Summary: We have developed a novel reporter line, free from complicating factors associated with previous alleles, for monitoring Dll4 expression, at a cellular resolution, in the developing and adult mouse.

METHODS & TECHNIQUES

  • Open Access
    Streamlined histone-based fluorescence lifetime imaging microscopy (FLIM) for studying chromatin organisation
    Alice Sherrard, Paul Bishop, Melanie Panagi, Maria Beatriz Villagomez, Dominic Alibhai, Abderrahmane Kaidi
    Biology Open 2018 7: bio031476 doi: 10.1242/bio.031476 Published 23 March 2018

    Summary: A streamlined and adaptable cell imaging method for quantitative analysis of chromatin organisation in mammalian cells, and its application, reveal a new role for ATM in regulating chromatin structure.

  • Open Access
    Establishment and long-term maintenance of primary intestinal epithelial cells cultured from the rainbow trout, Oncorhynchus mykiss
    Laura M. Langan, Stewart F. Owen, Awadhesh N. Jha
    Biology Open 2018 7: bio032870 doi: 10.1242/bio.032870 Published 7 March 2018

    Summary: Understanding chemical uptake from the diet is difficult in live fish: we developed long-term intestinal cell cultures that enables the science and provides an alternative method.

Back to top
PreviousNext
Previous IssueNext Issue

This issue

Biology Open: 7 (3)
  • Table of Contents (PDF)
  • About the Cover
  • Table of Contents
  • Index by author
  • Issue info (PDF)

RSSRSS Icon

JUMP TO

  • RESEARCH ARTICLES
  • METHODS & TECHNIQUES

  Alert me to new issues of Biology Open

  • Accepted manuscripts
  • Most-read
Loading
  • Open Access

    Smoking flies: Testing the effect of tobacco cigarettes on heart function of Drosophila melanogaster

    Manuela Santalla, Lucía Pagola, Ivana Gómez, Darío Balcazar, Carlos A. Valverde, Paola Ferrero
    PDF
  • Open Access

    Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry

    Hantian Qiu, Sayaka Fujisawa, Shohei Nozaki, Yohei Katoh, Kazuhisa Nakayama
    PDF
  • Open Access

    A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference

    Nina Graffmann, Audrey Ncube, Soraia Martins, Aurelian Robert Fiszl, Philipp Reuther, Martina Bohndorf, Wasco Wruck, Mathias Beller, Constantin Czekelius, James Adjaye
    PDF
  • Open Access

    A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and notch signaling

    Katherine K. Slemmons, Michael D. Deel, Yi-Tzu Lin, Kristianne M. Oristian, Nina Kuprasertkul, Katia C. Genadry, Po-Han Chen, Jen-Tsan Ashley Chi, Corinne M. Linardic
    PDF
  • Open Access

    Wound-induced polyploidization is dependent on integrin-yki signaling

    Rose Besen-McNally, Kayla J. Gjelsvik, Vicki P. Losick
    PDF
See more accepted manuscripts...

Other journals from The Company of Biologists

Development

Journal of Cell Science

Journal of Experimental Biology

Disease Models & Mechanisms

Advertisement

Biology Open and COVID-19

We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.

Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.


2020 at The Company of Biologists

Despite 2020’s challenges, we achieved a lot at The Company of Biologists. In the midst of the pandemic, we have seen long-term projects and new ventures come to fruition. Read our full lowdown of 2020.


Interview- Sebastian Markert

Sebastian Markert is first author of a paper in BiO using C. elegans to model amyotrophic lateral sclerosis. In an interview, he talks about the potential implications of his work and his future plans.


Three communities to support biologists to everywhere

Online communities have never been more important. If you’re looking for somewhere to meet fellow scientists, take part in topical discussions and find virtual events in your field, take a look at each of our community sites:

  • The Node: the community site for and by developmental biologists
  • preLights: the preprint highlights service run by the biological community
  • FocalPlane: the community site for microscopists and biologists alike

Articles

  • Accepted manuscripts
  • Issue in progress
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Interviews
  • Sign up for alerts

About us

  • About BiO
  • Editors and Board
  • Editor biographies
  • Grants and funding
  • Journal Meetings
  • Workshops
  • The Company of Biologists

For Authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Article types
  • Manuscript preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access

Journal Info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Sign up for alerts

Contact

  • Contact BiO
  • Advertising
  • Feedback

Twitter   YouTube   LinkedIn

© 2021   The Company of Biologists Ltd   Registered Charity 277992