RESEARCH ARTICLES
- Spindly is required for rapid migration of human cells
Summary: Spindly is a mitotic dynein/dynactin cofactor that influences chromosome alignment and division. In this report we present the first evidence that human Spindly has a role in interphase cell migration.
- Nitric oxide-mediated intersegmental modulation of cycle frequency in the crayfish swimmeret system
Summary: We develop a novel pharmacological approach using a nitric oxide donor and a nitric oxide synthase inhibitor to analyse modulation and segmental synchrony in the swimmeret rhythm of the crayfish.
- Cell-autonomous role of GFRα1 in the development of olfactory bulb GABAergic interneurons
Summary: Our data indicate that GFRα1 functions cell-autonomously in subpopulations of OB interneuron precursors to regulate their generation and allocation in the mammalian OB.
- Functional comparison of distinct Brachyury+ states in a renal differentiation assay
Summary: Brachyury-expressing mesoderm populations were generated from an E2-Crimson-expressing mESC reporter line using 3-D and 2-D culture systems and their differentiation potential was assessed following incorporation into mouse kidney rudiments.
- Fish learn collectively, but groups with differing personalities are slower to decide and more likely to split
Summary: Zebrafish groups were trained to make collective decisions and memorised locations by using cues. However, collective decisions were made slower by the splitting of groups comprising individuals of dissimilar personality.
- 1α,25(OH)2D3-glycosides from Solanum glaucophyllum leaves extract induce myoblasts differentiation through p38 MAPK and AKT activation
Summary: Solanum glaucophyllum leaf extract (SGE) contains 1α,25-dihydroxyvitamin D3-glycosides that promotes myoblast fusion through AKT and p38 MAPK pathways. Moreover, SGE regulates the expression of myoD1, myogenin and MCH2b at the beginning of differentiation.
- Osteoblast differentiation of equine induced pluripotent stem cells
Summary: Horse iPSCs can be turned directly into bone forming cells but the efficiency is affected by the donor horse. Less variability is observed using different iPSC lines derived from the same horse.
- KDM5B decommissions the H3K4 methylation landscape of self-renewal genes during trophoblast stem cell differentiation
Summary: The histone 3 lysine 4 demethylase KDM5B plays a key role in regulating H3K4 methylation during trophoblast stem cell self-renewal and differentiation. KDM5B regulates the transcriptional profile of TS cells during self-renewal and differentiation, and resets the H3K4 methylation landscape during differentiation by removing H3K4me3 from promoters of self-renewal and TS cell enriched genes.
- Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells
Summary: This study demonstrates differentiation of adult dermal fibroblast-derived iPSCs into neural crest and corneal endothelial-like cells, which could be a valuable tool for investigating the mechanisms of cornea endothelial disease.
- Tbx6 controls left-right asymmetry through regulation of Gdf1
Summary: Tbx6 affects morphology of the cilia of the node, but a leftward nodal flow is still generated. Downstream of nodal flow, Tbx6 regulates the Nodal coligand Gdf1 leading to disruption of left/right axis determination.
- Robust interaction of IFT70 with IFT52–IFT88 in the IFT-B complex is required for ciliogenesis
Summary: IFT70 is a subunit of the IFT-B complex involved in anterograde trafficking of ciliary proteins, including tubulins. IFT70-knockout cells failed to form cilia, indicating its essential role in tubulin trafficking.
- Tolerance to paternal genotoxic damage promotes survival during embryo development in zebrafish (Danio rerio)
Summary: In fish embryos, genomic instability generated by fertilization with DNA damaged sperm activates mechanisms of DNA damage tolerance, which seems to be mediated by Δ113p53 expression, promoting survival.
- Nonmuscle myosin IIA is involved in recruitment of apical junction components through activation of α-catenin
Summary: The establishment and regulation of cell adhesion are fundamental to the development and maintenance of tissue organization in multicellular organisms. The role of nonmuscle myosin IIA is studied.
- Selection of morphological features of pollen grains for chosen tree taxa
Summary: We present a novel method for selection of the sufficient pollen grains descriptors set, derived from optical microscopic images, for automatic pollen taxa recognition purposes.
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Biology Open and COVID-19
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Future Leader Review - Cardiac myosin super relaxation
A new Future Leader Review by Manuel Schmid and Christopher Toepfer discusses the rapidly-expanding field of myosin super relaxation in the context of cardiovascular disease. Read the full Review and their accompanying interview.
Find out more about our Future Leader Reviews – they are an exclusive opportunity for early-career researchers who want to establish themselves in their field.
An interview with Roberta Azzarelli
In an interview, first author Roberta Azzarelli discusses her 3D model of glioblastoma and shares her thoughts on how to improve the professional lives of early-career researchers: formal mentorship programmes, a clearly structured career path and taking part in initiatives such as the Node Network.
News from our sister journals
Development continues to run a successful new webinar series, Development presents…, while Journal of Cell Science has recently welcomed Esperanza Agullo-Pascual as FocalPlane’s new Community Manager. Journal of Experimental Biology’s new special issue highlights the role of comparative biology in tackling climate change and Liz Patton, the new Editor-in-Chief of Disease Models & Mechanisms, sets out her visions and priorities.