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  You have access

  Open access

July, 2018; 7 (7)

RESEARCH ARTICLES

  • Open Access
    Telomerase reverse transcriptase coordinates with the epithelial-to-mesenchymal transition through a feedback loop to define properties of breast cancer stem cells
    Ahmed El-Badawy, Nehal I. Ghoneim, Mohamed A. Nasr, Hoda Elkhenany, Toka A. Ahmed, Sara M. Ahmed, Nagwa El-Badri
    Biology Open 2018 7: bio034181 doi: 10.1242/bio.034181 Published 25 July 2018

    Summary: This study describe a reciprocal, bi-directional feedback loop between hTERT and EMT to regulate properties of CSCs, suggesting that targeting hTERT may eliminate CSCs, thereby preventing cancer progression.

  • Open Access
    Cell tracking in vitro reveals that the extracellular matrix glycoprotein Tenascin-C modulates cell cycle length and differentiation in neural stem/progenitor cells of the developing mouse spinal cord
    Marcus May, Bernd Denecke, Timm Schroeder, Magdalena Götz, Andreas Faissner
    Biology Open 2018 7: bio027730 doi: 10.1242/bio.027730 Published 25 July 2018

    Summary: We have shown, using digital video microscopy based cell lineage tracing, that the glycoprotein of the extracellular matrix tenascin-C modulates growth factor responsiveness and cell cycle length of embryonic spinal cord progenitor cells in vitro.

  • Open Access
    Coagulation factor 9-deficient mice are protected against dextran sulfate sodium-induced colitis
    Avinash Khandagale, Jens M. Kittner, Amrit Mann, Stefanie Ascher, Bettina Kollar, Christoph Reinhardt
    Biology Open 2018 7: bio034140 doi: 10.1242/bio.034140 Published 25 July 2018

    Summary: Since IBD incidence is less frequent in patients with inherited bleeding disorders, we explored and demonstrated that F9-deficiency is protective against DSS-induced acute colitis in a hemophilia B mouse model.

  • Open Access
    Formation of the sacrum requires down-regulation of sonic hedgehog signaling in the sacral intervertebral discs
    Raffaella Bonavita, Kathleen Vincent, Robert Pinelli, Chitra Lekha Dahia
    Biology Open 2018 7: bio035592 doi: 10.1242/bio.035592 Published 24 July 2018

    Summary: Loss of SHH signaling is associated with the collapse of the sacral discs and formation of the sacrum. Conditional reactivation of SHH re-awakens the sacral disc, suggesting its potential for disc regeneration.

  • Open Access
    Dynamic nuclear envelope phenotype in rats overexpressing mutated human torsinA protein
    Libo Yu-Taeger, Viktoria Gaiser, Larissa Lotzer, Tina Roenisch, Benedikt Timo Fabry, Janice Stricker-Shaver, Nicolas Casadei, Michael Walter, Martin Schaller, Olaf Riess, Huu Phuc Nguyen, Thomas Ott, Kathrin Grundmann-Hauser
    Biology Open 2018 7: bio032839 doi: 10.1242/bio.032839 Published 23 July 2018

    Summary: A novel transgenic rat model displaying dystonia-like phenotypes and dynamic processes in NE pathology can become a useful tool for therapy development for dystonia and other related diseases.

  • Open Access
    Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance
    David Mavor, Kyle A. Barlow, Daniel Asarnow, Yuliya Birman, Derek Britain, Weilin Chen, Evan M. Green, Lillian R. Kenner, Bruk Mensa, Leanna S. Morinishi, Charlotte A. Nelson, Erin M. Poss, Pooja Suresh, Ruilin Tian, Taylor Arhar, Beatrice E. Ary, David P. Bauer, Ian D. Bergman, Rachel M. Brunetti, Cynthia M. Chio, Shizhong A. Dai, Miles S. Dickinson, Susanna K. Elledge, Cole V. M. Helsell, Nathan L. Hendel, Emily Kang, Nadja Kern, Matvei S. Khoroshkin, Lisa L. Kirkemo, Greyson R. Lewis, Kevin Lou, Wesley M. Marin, Alison M. Maxwell, Peter F. McTigue, Douglas Myers-Turnbull, Tamas L. Nagy, Andrew M. Natale, Keely Oltion, Sergei Pourmal, Gabriel K. Reder, Nicholas J. Rettko, Peter J. Rohweder, Daniel M. C Schwarz, Sophia K. Tan, Paul V. Thomas, Ryan W. Tibble, Jason P. Town, Mary K. Tsai, Fatima S. Ugur, Douglas R. Wassarman, Alexander M. Wolff, Taia S. Wu, Derek Bogdanoff, Jennifer Li, Kurt S. Thorn, Shane O'Conchúir, Danielle L. Swaney, Eric D. Chow, Hiten D. Madhani, Sy Redding, Daniel N. Bolon, Tanja Kortemme, Joseph L. DeRisi, Martin Kampmann, James S. Fraser
    Biology Open 2018 7: bio036103 doi: 10.1242/bio.036103 Published 23 July 2018

    Summary: We organized a project-based course that used deep mutational scanning of ubiquitin to resolve the inconsistencies between tolerance to mutations in laboratory conditions and sequence conservation over evolutionary timescales.

  • Open Access
    Location and functions of Inebriated in the Drosophila eye
    Janusz Borycz, Anna Ziegler, Jolanta A. Borycz, Guido Uhlenbrock, Daniel Tapken, Lucia Caceres, Michael Hollmann, Bernhard T. Hovemann, Ian A. Meinertzhagen
    Biology Open 2018 7: bio034926 doi: 10.1242/bio.034926 Published 23 July 2018

    Summary: Inebriated isoforms express in alternating glial layers of the Drosophila visual system, consistent with a role in histamine recycling in the eye, and its mutants exhibit blue light phototaxis defects.

  • Open Access
    Impact of ambient temperature on energy cost and economical speed during level walking in healthy young males
    Masahiro Horiuchi, Yoko Handa, Yoshiyuki Fukuoka
    Biology Open 2018 7: bio035121 doi: 10.1242/bio.035121 Published 16 July 2018

    Summary: Energy cost of walking in a hot environment was greater than in a comfortable environment. Thus, to prevent heat related injury, walking speed should be reduced in a hot environment.

  • Open Access
    Effect of initial body orientation on escape probability of prey fish escaping from predators
    Hibiki Kimura, Yuuki Kawabata
    Biology Open 2018 7: bio023812 doi: 10.1242/bio.023812 Published 16 July 2018

    Summary: Our predator-prey experiments reveal that prey's initial body orientation relative to a predator affects the flight initiation distance and turn duration of prey and consequently affects escape probability.

  • Open Access
    Simultaneous recordings of action potentials and calcium transients from human induced pluripotent stem cell derived cardiomyocytes
    Chandra Prajapati, Risto-Pekka Pölönen, Katriina Aalto-Setälä
    Biology Open 2018 7: bio035030 doi: 10.1242/bio.035030 Published 16 July 2018

    Summary: We performed simultaneous recordings of action potentials and calcium transients from the same cardiomyocytes to improve understanding of the mechanisms underlying arrhythmias and the correlation between these two parameters.

  • Open Access
    PRP-19, a conserved pre-mRNA processing factor and E3 ubiquitin ligase, inhibits the nuclear accumulation of GLP-1/Notch intracellular domain
    Silvia Gutnik, Yann Thomas, Yanwu Guo, Janosch Stoecklin, Anca Neagu, Lionel Pintard, Jorge Merlet, Rafal Ciosk
    Biology Open 2018 7: bio034066 doi: 10.1242/bio.034066 Published 16 July 2018

    Summary: GFP tagging of endogenous GLP-1/Notch revealed life stage-specific differences in the nuclear accumulation of GLP-1 intracellular domain, which are mediated by the ubiquitin-proteolytic system and the splicing factor/E3 ubiquitin ligase PRP-19.

  • Open Access
    Characterisation of cellular effects of Burkholderia pseudomallei cycle inhibiting factor (Cif)
    Mei Ying Ng, Yunn-Hwen Gan, Thilo Hagen
    Biology Open 2018 7: bio028225 doi: 10.1242/bio.028225 Published 16 July 2018

    Summary: Cycle inhibiting factor (Cif) is a Burkholderia pseudomallei virulence factor and is shown to exert both Cullin RING E3 ligase dependent and independent effects on host cells.

  • Open Access
    Prednisolone induces osteoporosis-like phenotypes via focal adhesion signaling pathway in zebrafish larvae
    Lei Huo, Lei Wang, Zhaoyao Yang, Pingyuan Li, Dechun Geng, Yaozeng Xu
    Biology Open 2018 7: bio029405 doi: 10.1242/bio.029405 Published 16 July 2018

    Summary: Glucocorticoids may contribute to osteoporosis through effects on the extracellular region, the extracellular matrix and collagen trimer, and focal adhesion signaling pathway genes (itga10 and itgbl1).

  • Open Access
    Characterization of a cdc14 null allele in Drosophila melanogaster
    Leif R. Neitzel, Matthew R. Broadus, Nailing Zhang, Leah Sawyer, Heather A. Wallace, Julie A. Merkle, Jeanne N. Jodoin, Poojitha Sitaram, Emily E. Crispi, William Rork, Laura A. Lee, Duojia Pan, Kathleen L. Gould, Andrea Page-McCaw, Ethan Lee
    Biology Open 2018 7: bio035394 doi: 10.1242/bio.035394 Published 9 July 2018

    Summary: The Cdc14 phosphatase has been implicated in cell cycle regulation in S. cerevisiae. We show that Drosophila cdc14 mutants are viable, but exhibit defects in sperm competition, chemosensation, and mechanosensation.

  • Open Access
    Non-invasive assessment of liver disease in rats using multiparametric magnetic resonance imaging: a feasibility study
    Anna M. Hoy, Natasha McDonald, Ross J. Lennen, Matteo Milanesi, Amy H. Herlihy, Timothy J. Kendall, William Mungall, Michael Gyngell, Rajarshi Banerjee, Robert L. Janiczek, Philip S. Murphy, Maurits A. Jansen, Jonathan A. Fallowfield
    Biology Open 2018 7: bio033910 doi: 10.1242/bio.033910 Published 2 July 2018

    Summary: Multiparametric liver MRI was feasible in experimental rat models and imaging parameters correlated with gold standard histopathological assessments, especially characteristics of fatty liver disease.

  • Open Access
    Exposure of zebra mussels to extracorporeal shock waves demonstrates formation of new mineralized tissue inside and outside the focus zone
    Katharina Sternecker, Juergen Geist, Sebastian Beggel, Kristin Dietz-Laursonn, Matias de la Fuente, Hans-Georg Frank, John P. Furia, Stefan Milz, Christoph Schmitz
    Biology Open 2018 7: bio033258 doi: 10.1242/bio.033258 Published 2 July 2018

    Summary: The use of zebra mussels in research on extracorporeal shock wave (ESW) therapy for fracture nonunions allows new insights into the complex process of induction of biomineralization by ESWs.

METHODS & TECHNIQUES

  • Open Access
    High-throughput live-imaging of embryos in microwell arrays using a modular specimen mounting system
    Seth Donoughe, Chiyoung Kim, Cassandra G. Extavour
    Biology Open 2018 7: bio031260 doi: 10.1242/bio.031260 Published 9 July 2018

    Summary: This Methods & Techniques article describes a customizable device for mounting and live-imaging a wide range of tissues and species; complete design files and instructions for assembly are included.

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Biology Open: 7 (7)
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  • Open Access

    Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype

    Xinhong Liu, Yu-Gang Li, Fang Tan, Jia Liu, Ruokun Yi, Xin Zhao
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  • Open Access

    Oviductal fluid counterbalances the negative effect of high temperature on sperm in an ectotherm model

    N. Rossi, G. Lopez Juri, M. Chiaraviglio, G. Cardozo
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  • Open Access

    High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway

    Wanxu Guo, Hang Gao, Wei Pan, Panapn Yu, Guanghua Che
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  • Open Access

    Overexpression of long non-coding RNA SBF2-AS1 promotes cell progression in esophageal squamous cell carcinoma (ESCC) by repressing miR-494 to up-regulate PFN2 expression

    Qiu Zhang, Xixiang Pan, Dongyang You
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