Article Figures & Tables
Figures
- Fig. 1.
MRI assessment of hepatic fibro-inflammatory injury in rat CCl4 model. (A) Quantification of hepatic collagen content (% area of Picrosirius Red staining). (B) Representative examples of transverse liver MR T1 relaxation maps. (C) T1 relaxation quantification in rats receiving CCl4 or OO for 4 and 12 weeks. (D) Correlation between hepatic collagen content and T1 in rats receiving CCl4 and OO for 12 weeks. Data presented as mean±s.d., analyzed by unpaired t-test (*P<0.05, **P<0.01). Spearman (rs) correlation coefficient was used to examine correlations.
- Fig. 2.
MRI assessment of hepatic steatosis and steatotic inflammatory injury in rat MCD diet model. (A) Representative examples of transverse liver MR PDFF maps. (B) Quantification of Oil Red O (ORO) staining of hepatic fat. (C) Quantification of hepatic PDFF. (D-F) Correlations between hepatic PDFF and (D) histologically assessed steatosis, (E) steatotic inflammatory injury [N(m)AS] and (F) ORO staining in rats receiving MCD or control diet (N) for 4 and 8 weeks. Data presented as mean±s.d., analyzed by unpaired t-test (**P<0.01, ***P<0.001, ****P<0.0001). Spearman (rs) correlation coefficient was used to examine correlations.
- Fig. 3.
MRI assessment of hepatic steatosis and steatohepatitis in rat CCl4 model. (A) Representative examples of transverse liver MR PDFF maps. (B) Quantification of Oil Red O (ORO) staining of hepatic fat. (C) Quantification of hepatic proton density fat fraction (PDFF). (D,E) Correlations between hepatic PDFF and (D) histologically assessed ORO staining and (E) steatotic inflammatory injury [N(m)AS] in rats receiving CCl4 or olive oil (OO) for 4 and 12 weeks. Data presented as mean±s.d., analyzed by unpaired t-test (*P<0.05, **P<0.01). Spearman (rs) correlation coefficient was used to examine correlations.
- Fig. 4.
MRI assessment of hepatic steatosis and steatohepatitis in cilostazol-treated rats on MCD diet. Sprague-Dawley rats received MCD diet for 4 weeks plus cliostazol or vehicle for the last 2 weeks of the model. Animals were scanned at baseline and after 4 weeks. (A) Quantification of hepatic fat by morphometry based on H&E staining. (B) Steatotic inflammatory injury [N(m)AS]. (C) Representative examples of transverse liver MR proton density fat fraction (PDFF). (D) Quantification of hepatic PDFF. (E) Correlation between PDFF and steatotic inflammatory injury [N(m)AS]. Data presented as mean±s.d., analyzed by unpaired t-test. Spearman (rs) correlation coefficient was used to examine correlations.
- Fig. 5.
MRI assessment of T2*/R2* relaxation in preclinical liver injury models. (A) Representative examples of transverse liver MR T2* maps. (B) Quantification of R2* (1/T2*) in rats receiving CCl4 or olive oil (OO) for 4 and 12 weeks. (C) Quantification of R2* (1/T2*) in rats receiving MCD or control diet (N) for 4 and 8 weeks. (D) Correlation between R2* and PDFF in animals receiving CCl4 or OO injections and MCD or control diets. Data presented as mean±s.d., analyzed by unpaired t-test (****P<0.0001). Spearman (rs) correlation coefficient was used to examine correlations.
- Fig. 6.
Rat models of chronic liver disease. *1 rat euthanized prematurely due to poor health.
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