Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Interviews
    • Sign up for alerts
  • About us
    • About BiO
    • Editors and Board
    • Editor biographies
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contact
    • Contact BiO
    • Advertising
    • Feedback
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

User menu

  • Log in

Search

  • Advanced search
Biology Open
  • COB
    • About The Company of Biologists
    • Development
    • Journal of Cell Science
    • Journal of Experimental Biology
    • Disease Models & Mechanisms
    • Biology Open

supporting biologistsinspiring biology

Biology Open

Advanced search

RSS   Twitter   Facebook   YouTube

  • Home
  • Articles
    • Accepted manuscripts
    • Issue in progress
    • Latest complete issue
    • Issue archive
    • Archive by article type
    • Interviews
    • Sign up for alerts
  • About us
    • About BiO
    • Editors and Board
    • Editor biographies
    • Grants and funding
    • Journal Meetings
    • Workshops
    • The Company of Biologists
    • Journal news
  • For authors
    • Submit a manuscript
    • Aims and scope
    • Presubmission enquiries
    • Article types
    • Manuscript preparation
    • Cover suggestions
    • Editorial process
    • Promoting your paper
    • Open Access
  • Journal info
    • Journal policies
    • Rights and permissions
    • Media policies
    • Reviewer guide
    • Sign up for alerts
  • Contact
    • Contact BiO
    • Advertising
    • Feedback

 

  You have access

  Open access

January, 2019; 8 (1)

RESEARCH ARTICLES

  • Open Access
    A neurodevelopmental TUBB2B β-tubulin mutation impairs Bim1 (yeast EB1)-dependent spindle positioning
    Eric Denarier, Carine Brousse, Abdoulaye Sissoko, Annie Andrieux, Cécile Boscheron
    Biology Open 2019 8: bio038620 doi: 10.1242/bio.038620 Published 29 January 2019

    Summary: Patients with intellectual disabilities carry a F265L mutation in TUBB2B β-tubulin gene. Yeast used as a cellular model reveals spindle mis-positioning associated with reduced yeast EB1 affinity for microtubule plus-ends.

  • Open Access
    Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation
    Magali Roques, Rebecca R. Stanway, Edward I. Rea, Robert Markus, Declan Brady, Anthony A. Holder, David S. Guttery, Rita Tewari
    Biology Open 2019 8: bio036822 doi: 10.1242/bio.036822 Published 29 January 2019

    Summary: This study examines the localization of malaria parasite centrin PbCEN4 at the parasite MTOC during closed endomitosis and shows it to be dispensable for proliferation.

  • Open Access
    E-cadherin, actin, microtubules and FAK dominate different spheroid formation phases and important elements of tissue integrity
    I. Smyrek, B. Mathew, S. C. Fischer, S. M. Lissek, S. Becker, E. H. K. Stelzer
    Biology Open 2019 8: bio037051 doi: 10.1242/bio.037051 Published 24 January 2019

    Summary: The phases of spheroid formation resemble different stages of cell contact formation. This facilitates studying the temporal contribution of molecules in this process.

  • Open Access
    Folic acid modifies the shape of epithelial cells during morphogenesis via a Folr1 and MLCK dependent mechanism
    Jessica B. Martin, Maria Muccioli, Kenneth Herman, Richard H. Finnell, Timothy F. Plageman, Jr
    Biology Open 2019 8: bio041160 doi: 10.1242/bio.041160 Published 22 January 2019

    Summary: This manuscript describes a putative mechanism by which folic acid modifies epithelial cell shape during morphogenesis, shedding light onto the mechanism by which folic acid may prevent neural tube defects.

  • Open Access
    Three-dimensional movements of the pectoral fin during yaw turns in the Pacific spiny dogfish, Squalus suckleyi
    Sarah L. Hoffmann, Cassandra M. Donatelli, Samantha C. Leigh, Elizabeth L. Brainerd, Marianne E. Porter
    Biology Open 2019 8: bio037291 doi: 10.1242/bio.037291 Published 17 January 2019

    Summary: Pacific spiny dogfish rotate the inside pectoral fin consistently about three axes during yaw turning, which correlates with turning performance. Stimulation experiments confirm hypotheses about muscle function in controlling actuation.

  • Open Access
    Maintenance of cell fates and regulation of the histone variant H3.3 by TLK kinase in Caenorhabditis elegans
    Yukimasa Shibata, Yoshiyuki Seki, Kiyoji Nishiwaki
    Biology Open 2019 8: bio038448 doi: 10.1242/bio.038448 Published 17 January 2019

    Summary: Histone H3 chaperone CAF1 maintains cell fate by repressing ectopic expression of genes for cell fate-specifying transcription factors. Accumulation of histone variant H3.3 correlates with defects in cell-fate maintenance.

  • Open Access
    IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model
    Junqiong Huang, Huan Yue, Tao Jiang, Jing Gao, Yu Shi, Bin Shi, Xiaoxue Wu, Xiaoqin Gou
    Biology Open 2019 8: bio036244 doi: 10.1242/bio.036244 Published 15 January 2019

    Summary: IL-31 plays dual roles, acting as an early inflammatory mediator promoting the secretion of chemokines to recruit inflammatory cells and subsequent negative feedback pathway for suppressing the magnitude of type 2 inflammation.

  • Open Access
    The 17β-estradiol induced upregulation of the adhesion G-protein coupled receptor (ADGRG7) is modulated by ESRα and SP1 complex
    Amani Hassan, Edward T. Bagu, Mathieu Levesque, Shunmoogum A. Patten, Samira Benhadjeba, Lydia Edjekouane, Isabelle Villemure, André Tremblay, Florina Moldovan
    Biology Open 2019 8: bio037390 doi: 10.1242/bio.037390 Published 14 January 2019

    Summary: Estrogen plays a significant role in AIS and studying the regulation of ADGRG7 by E2 in AIS cells is essential for understanding molecular mechanisms underlying AIS pathogenesis.

  • Open Access
    Local deformation and stiffness distribution in fly wings
    Henja-Niniane Wehmann, Lars Heepe, Stanislav N. Gorb, Thomas Engels, Fritz-Olaf Lehmann
    Biology Open 2019 8: bio038299 doi: 10.1242/bio.038299 Published 14 January 2019

    Summary: We determined mechanical properties of wings under load in three fly species. Fly wings broadly deform similar to homogenous beams. Veins and joints shape wing mechanics and govern wing deformation during flapping flight.

  • Open Access
    Treatment with methyl-β-cyclodextrin prevents mechanical allodynia in resiniferatoxin neuropathy in a mouse model
    Chih-Lung Lin, Chin-Hong Chang, Ying-Shuang Chang, Shui-Chin Lu, Yu-Lin Hsieh
    Biology Open 2019 8: bio039511 doi: 10.1242/bio.039511 Published 14 January 2019

    Summary: The role and mechanism of cholesterol-rich membrane integrity in pain development for small-fiber neuropathy remains unclear. Depletion of membrane cholesterol contents preserves functional PAP profiles and the antinociceptive effect after RTX neuropathy.

  • Open Access
    The role of retrograde intraflagellar transport genes in aminoglycoside-induced hair cell death
    Tamara M. Stawicki, Tor Linbo, Liana Hernandez, Lauren Parkinson, Danielle Bellefeuille, Edwin W. Rubel, David W. Raible
    Biology Open 2019 8: bio038745 doi: 10.1242/bio.038745 Published 14 January 2019

    Summary: Here we show that both retrograde intraflagellar transport motor proteins and IFT-A adaptor molecules play a role in aminoglycoside-induced hair cell death, seemingly through regulating aminoglycoside uptake.

  • Open Access
    Influence of substrate orientation on tadpoles' feeding efficiency
    Fabiane Santana Annibale, Verônica Thiemi Tsutae de Sousa, Carlos Eduardo de Sousa, Matthew D. Venesky, Denise de Cerqueira Rossa-Feres, Fausto Nomura, Richard J. Wassersug
    Biology Open 2019 8: bio037598 doi: 10.1242/bio.037598 Published 14 January 2019

    Summary: We provide new insights on species' niche partitioning as we show that the orientation of substrates can affect the growth rates of tadpoles with different oral morphologies.

  • Open Access
    Roles of Keber's valve and foot chamber for foot manipulation in the mussel Nodularia douglasiae
    Eriko Seo, Yoshiteru Seo
    Biology Open 2019 8: bio039859 doi: 10.1242/bio.039859 Published 14 January 2019

    Summary: Opening and closing of Keber's valve in the mussel was visualized using MRI. Keber's valve and the foot chamber are essential for circulation at rest and during foot extension and retraction.

  • Open Access
    The ATPase TER94 regulates Notch signaling during Drosophila wing development
    Yunlong Li, Tong Liu, Junzheng Zhang
    Biology Open 2019 8: bio038984 doi: 10.1242/bio.038984 Published 10 January 2019

    Summary: Our study demonstrates that the ATPase TER94 and the p47 adaptor positively regulate Notch signaling during Drosophila wing development, thus establishing a functional interaction between TER94 and Notch signaling activity.

  • Open Access
    Contribution of non-circadian neurons to the temporal organization of locomotor activity
    Nicolás Pírez, Sofia G. Bernabei-Cornejo, Magdalena Fernandez-Acosta, José M. Duhart, M. Fernanda Ceriani
    Biology Open 2019 8: bio039628 doi: 10.1242/bio.039628 Published 7 January 2019

    Summary: Here we characterized the impact of different putative postsynaptic partners of the sLNvs on the control of rhythmic locomotor behavior. We found that some of these novel neuronal clusters are relevant for the control of locomotor activity.

  • Open Access
    Localized disorganization of the cochlear inner hair cell synaptic region after noise exposure
    Anwen Bullen, Lucy Anderson, Warren Bakay, Andrew Forge
    Biology Open 2019 8: bio038547 doi: 10.1242/bio.038547 Published 7 January 2019

    Summary: Hearing deficits after noise exposure are linked to afferent terminal loss. We show that afferent terminal loss is concomitant with changes to inner hair cell pre-synaptic ultrastructure indicating vesicle-recycling deficits.

  • Open Access
    Genome-wide identification of lncRNAs and mRNAs differentially expressed in non-functioning pituitary adenoma and construction of an lncRNA-mRNA co-expression network
    Weikang Xing, Zhenyu Qi, Cheng Huang, Nan Zhang, Wei Zhang, Yao Li, Minyan Qiu, Qi Fang, Guozhen Hui
    Biology Open 2019 8: bio037127 doi: 10.1242/bio.037127 Published 4 January 2019

    Summary statement: We identified long non-coding RNAs and mRNAs differentially expressed in non-functioning pituitary adenomas via microarray analyses, and provided working hypotheses for how these RNAs may function via co-expression network analyses.

  • Open Access
    Integral gene drives for population replacement
    Alexander Nash, Giulia Mignini Urdaneta, Andrea K. Beaghton, Astrid Hoermann, Philippos Aris Papathanos, George K. Christophides, Nikolai Windbichler
    Biology Open 2019 8: bio037762 doi: 10.1242/bio.037762 Published 3 January 2019

    Summary: Here, we describe and model a novel gene drive strategy – integral gene drive – for population replacement based on the hijacking of endogenous genes.

  • Open Access
    Development and characterization of a new cell line derived from European eel Anguilla anguilla kidney
    Bin Chen, Zaiyu Zheng, Jinxian Yang, Hongshu Chi, He Huang, Hui Gong
    Biology Open 2019 8: bio037507 doi: 10.1242/bio.037507 Published 2 January 2019

    Summary: The first visceral cell line of an endangered species, Anguilla anguilla has been established; this aneuploid cell line is fibroblast-like, and suitable for gene expression and virus isolation.

  • Open Access
    Glucose starvation triggers filamentous septin assemblies in an S. pombe septin-2 deletion mutant
    Minghua Liu, Maria B. Heimlicher, Mirjam Bächler, Chieze C. Ibeneche-Nnewihe, Ernst-Ludwig Florin, Damian Brunner, Andreas Hoenger
    Biology Open 2019 8: bio037622 doi: 10.1242/bio.037622 Published 2 January 2019

    Summary: We present a correlative electron tomography and light microscopy study on yeast cells under glucose starvation. We visualized several novel effects such as septin bundling and mitochondrial fission followed by ribosome decoration.

  • Open Access
    Hypoxia evokes increased PDI and PDIA6 expression in the infarcted myocardium of ex-germ-free and conventionally raised mice
    Klytaimnistra Kiouptsi, Stefanie Finger, Venkata S. Garlapati, Maike Knorr, Moritz Brandt, Ulrich Walter, Philip Wenzel, Christoph Reinhardt
    Biology Open 2019 8: bio038851 doi: 10.1242/bio.038851 Published 2 January 2019

    Summary: We identified PDIA6 as a hypoxia-induced element of the unfolded protein response in cardiomyocytes and infarcted mouse hearts. PDIA6 expression and ejection fractions were reduced in infarcted ex-germ-free mouse hearts.

  • Open Access
    Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases
    Federica Riccio, Sandeep K. Talapatra, Sally Oxenford, Richard Angell, Michela Mazzon, Frank Kozielski
    Biology Open 2019 8: bio037663 doi: 10.1242/bio.037663 Published 2 January 2019

    Summary: We have developed a 96-well crystallization screen for viral RNA-dependent RNA polymerases (RdRps). The screen provides a convenient platform for streamlining the crystallisation of RdRps and implementing structure-based drug discovery programs.

METHODS & TECHNIQUES

  • Open Access
    GFP-Forked, a genetic reporter for studying Drosophila oocyte polarity
    Raju Baskar, Anna Bakrhat, Uri Abdu
    Biology Open 2019 8: bio039552 doi: 10.1242/bio.039552 Published 17 January 2019

    Summary: The novel asymmetric Forked network could be used as a genetic reporter for visualizing and studying oocyte polarity.

  • Open Access
    Improved dynamic monitoring of transcriptional activity during longitudinal analysis in the mouse brain
    Hwon Heo, Juyeong Jo, Jae In Jung, Young-Min Han, Seongsoo Lee, Song Rae Kim, Seung-Hae Kwon, Kil-Nam Kim, Byung Joon Hwang, Yun Kee, Byoung Dae Lee, Dongmin Kang, Song Her
    Biology Open 2019 8: bio037168 doi: 10.1242/bio.037168 Published 8 January 2019

    Summary: A platform for pin-point monitoring transcription activity in the deep brain of the mouse with high spatiotemporal resolution was developed, which is adaptable to various transcription factor arrays and targets.

FIRST PERSON

  • Open Access
    First person – Sarah Hoffmann
    Biology Open 2019 8: bio040972 doi: 10.1242/bio.040972 Published 17 January 2019
  • Open Access
    First person – Amani Hassan
    Biology Open 2019 8: bio039792 doi: 10.1242/bio.039792 Published 14 January 2019
  • Open Access
    First person – Eriko Seo
    Biology Open 2019 8: bio041129 doi: 10.1242/bio.041129 Published 14 January 2019
  • Open Access
    First person – Yunlong Li
    Biology Open 2019 8: bio041046 doi: 10.1242/bio.041046 Published 10 January 2019
  • Open Access
    First person – Klytaimnistra Kiouptsi
    Biology Open 2019 8: bio040642 doi: 10.1242/bio.040642 Published 2 January 2019
Back to top
PreviousNext
Previous IssueNext Issue

This issue

Biology Open: 8 (1)
  • Table of Contents (PDF)
  • About the Cover
  • Table of Contents
  • Index by author
  • Issue info (PDF)

RSSRSS Icon

JUMP TO

  • RESEARCH ARTICLES
  • METHODS & TECHNIQUES
  • FIRST PERSON

  Alert me to new issues of Biology Open

  • Accepted manuscripts
  • Most-read
Loading
  • Open Access

    Three functional polymorphisms in CCDC170 were associated with osteoporosis phenotype

    Xinhong Liu, Yu-Gang Li, Fang Tan, Jia Liu, Ruokun Yi, Xin Zhao
    PDF
  • Open Access

    Oviductal fluid counterbalances the negative effect of high temperature on sperm in an ectotherm model

    N. Rossi, G. Lopez Juri, M. Chiaraviglio, G. Cardozo
    PDF
  • Open Access

    High glucose induces Nox4 expression and podocyte apoptosis through the Smad3/ezrin/PKA pathway

    Wanxu Guo, Hang Gao, Wei Pan, Panapn Yu, Guanghua Che
    PDF
  • Open Access

    Overexpression of long non-coding RNA SBF2-AS1 promotes cell progression in esophageal squamous cell carcinoma (ESCC) by repressing miR-494 to up-regulate PFN2 expression

    Qiu Zhang, Xixiang Pan, Dongyang You
    PDF
See more accepted manuscripts...

Other journals from The Company of Biologists

Development

Journal of Cell Science

Journal of Experimental Biology

Disease Models & Mechanisms

Advertisement

Biology Open and COVID-19

We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.

Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.


Future Leader Review - Cardiac myosin super relaxation

A new Future Leader Review by Manuel Schmid and Christopher Toepfer discusses the rapidly-expanding field of myosin super relaxation in the context of cardiovascular disease. Read the full Review and their accompanying interview.

Find out more about our Future Leader Reviews – they are an exclusive opportunity for early-career researchers who want to establish themselves in their field.


An interview with Roberta Azzarelli

In an interview, first author Roberta Azzarelli discusses her 3D model of glioblastoma and shares her thoughts on how to improve the professional lives of early-career researchers: formal mentorship programmes, a clearly structured career path and taking part in initiatives such as the Node Network.


News from our sister journals

Development continues to run a successful new webinar series, Development presents…, while Journal of Cell Science has recently welcomed Esperanza Agullo-Pascual as FocalPlane’s new Community Manager. Journal of Experimental Biology’s new special issue highlights the role of comparative biology in tackling climate change and Liz Patton, the new Editor-in-Chief of Disease Models & Mechanisms, sets out her visions and priorities.

Articles

  • Accepted manuscripts
  • Issue in progress
  • Latest complete issue
  • Issue archive
  • Archive by article type
  • Interviews
  • Sign up for alerts

About us

  • About BiO
  • Editors and Board
  • Editor biographies
  • Grants and funding
  • Journal Meetings
  • Workshops
  • The Company of Biologists

For Authors

  • Submit a manuscript
  • Aims and scope
  • Presubmission enquiries
  • Article types
  • Manuscript preparation
  • Cover suggestions
  • Editorial process
  • Promoting your paper
  • Open Access

Journal Info

  • Journal policies
  • Rights and permissions
  • Media policies
  • Reviewer guide
  • Sign up for alerts

Contact

  • Contact BiO
  • Advertising
  • Feedback

Twitter   YouTube   LinkedIn

© 2021   The Company of Biologists Ltd   Registered Charity 277992