This issue is currently being compiled. Articles in their final version of record are published here as soon as they are ready. The most recent articles appear at the top of the relevant section.
RESEARCH ARTICLES
- Heparan sulfate negatively regulates intestinal stem cell proliferation in Drosophila adult midgut
Summary: Heparan sulfate chains in Drosophila adult intestinal stem cells negatively regulate stem cell proliferation and differentiation to control tissue homeostasis under physiological conditions.
- Long non-coding RNA SNHG1 indicates poor prognosis and facilitates disease progression in acute myeloid leukemia
Summary: Long non-coding RNA SNHG1 can facilitate the progression of acute myeloid leukemia by targeting an anti-tumor miR-101, and the upregulation of SNHG1 can predict poor prognosis in acute myeloid leukemia.
- Acid sphingomyelinase regulates the localization and trafficking of palmitoylated proteins
Summary: Acid sphingomyelinase (ASM) regulates palmitoylated protein trafficking and localization.
- Heterogeneous beta-catenin activation is sufficient to cause hepatocellular carcinoma in zebrafish
Summary: Here we show that expression of activated β-catenin in a subset of early hepatocytes is sufficient to drive liver tumorigenesis. Heterogeneity in β-catenin activation continues during HCC progression.
- Endurance exercise resistance to lipotoxic cardiomyopathy is associated with cardiac NAD+/dSIR2/PGC-1α pathway activation in old Drosophila
Summary: Exercise training prevents lipotoxic cardiomyopathy induced by a high-fat diet or cardiac dSir2 knockdown in old Drosophila.
- Restriction of mitochondrial calcium overload by mcu inactivation renders a neuroprotective effect in zebrafish models of Parkinson's disease
Summary: Mitochondrial calcium overload causes mitochondrial dysfunction in Parkinson's disease. Inactivation of mitochondrial calcium uniporter reverses mitochondrial calcium overload and rescues dopaminergic neurons in our zebrafish models of Parkinson's disease.
- Targeting of copper-trafficking chaperones causes gene-specific systemic pathology in Drosophila melanogaster: prospective expansion of mutational landscapes that regulate tumor resistance to cisplatin
Summary: We demonstrate the essential roles of Atox1 and CCS copper-trafficking chaperones in Drosophila development and aging. We also provide insights for their therapeutic exploitation as cisplatin regulators during cancer chemotherapy.
- Luminal-contact-inhibition of epithelial basal stem cell multipotency in prostate organogenesis and homeostasis
Summary: Lineage tracing shows that ablation of prostate luminal cells reactivates adult basal cell multipotency, while luminal–basal cell contact inhibits basal stem cell activities in organoids.
METHODS AND TECHNIQUES
- Computational analysis of size, shape and structure of insect wings
Summary: We provide a set of simple quantitative measures to compare morphological variation in size, shape, and structure of insect wings across species, families and orders.
FIRST PERSON
This issue
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Cover article - Apolipoprotein L9 interacts with LC3/GABARAP and is a microtubule-associated protein with a widespread subcellular distribution
Arvind A. Thekkinghat, Kamlesh K. Yadav and Pundi N. Rangarajan demonstrate the versatile properties of apolipoprotein L9, a lipid-binding protein, and its influence on a variety of activities taking place inside an animal cell.
James J. Dowling and his colleagues conducted the first large-scale screening efforts for NEBLUN-related nemaline myopathy to address the urgent need for effective treatment for patients affected by the disease.
Have you seen our interviews with the early-career first authors of our papers? Recently, we caught up with first authors Arvind Thekkinghat, Shannon Taylor and Daisuke Takao.
Biology Open has strong credentials and publishing with us is easy and fast. BiO aims to provide rapid publication for scientifically sound observations and valid conclusions in developmental, cell, experimental and translational biology. Submit your paper here – you’ll be in good company!
Recent developmental biology highlights in BiO – Anna Nele Herdina and her colleagues define the spectrum of phenotypic abnormalities linked with Col4a2 disruption, and demonstrate the opportunities the Deciphering the Mechanisms of Developmental Disorders (DMDD) program offers for exploring rare human diseases.
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preLights - preLights reaches 500 posts!
The success of preLights is down to the hard work of our preLighters. Head over to the preLights website to find out more about our most active early-career researchers.