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  You have access

  Open access

October, 2019; 8 (10)

RESEARCH ARTICLES

  • Open Access
    Perturbation of maternal PIASy abundance disrupts zygotic genome activation and embryonic development via SUMOylation pathway
    Chika Higuchi, Mari Yamamoto, Seung-Wook Shin, Kei Miyamoto, Kazuya Matsumoto
    Biology Open 2019 8: bio048652 doi: 10.1242/bio.048652 Published 29 October 2019

    Summary: Maternal protein degradation is one developmental event leading to acquiring totipotency. PIASy is identified as a maternal protein that is degraded for accomplishing zygotic transcription and development.

  • Open Access
    Tests of the chromatographic theory of olfaction with highly soluble odors: a combined electro-olfactogram and computational fluid dynamics study in the mouse
    David M. Coppola, Emily Fitzwater, Alex D. Rygg, Brent A. Craven
    Biology Open 2019 8: bio047217 doi: 10.1242/bio.047217 Published 25 October 2019

    Summary: This paper casts doubt on the classical chromatographic theory of olfaction, showing there is no correlation between olfactory receptor spatial layout and odor solubility patterns, a necessary condition of the theory.

  • Open Access
    Immune response of hibernating European bats to a fungal challenge
    Marcus Fritze, David Costantini, Jörns Fickel, Dana Wehner, Gábor Á. Czirják, Christian C. Voigt
    Biology Open 2019 8: bio046078 doi: 10.1242/bio.046078 Published 1 November 2019

    Summary: Our experimental immunological study on European bats provides new information on the functionality of the immune system in hibernation. For this we challenged bats with a fungal antigen and measured different immunological parameters.

  • Open Access
    Heterogeneity and plasticity of porcine alveolar macrophage and pulmonary interstitial macrophage isolated from healthy pigs in vitro
    Huan Liu, Jia Liu, Jing Huang, Xianchang Bai, Qinfu Wang
    Biology Open 2019 8: bio046342 doi: 10.1242/bio.046342 Published 24 October 2019

    Summary: The heterogeneity and plasticity of macrophages will be helpful for the understanding of pathologic mechanisms and the prevention of swine infectious disease.

  • Open Access
    CLASP promotes microtubule bundling in metaphase spindle independently of Ase1/PRC1 in fission yeast
    Hirohisa Ebina, Liang Ji, Masamitsu Sato
    Biology Open 2019 8: bio045716 doi: 10.1242/bio.045716 Published 24 October 2019

    Summary: The conserved microtubule-associated protein CLASP/Peg1/Cls1 bundles microtubules of the metaphase spindle in fission yeast. Unlike its conventional role in anaphase, this CLASP function does not depend upon Ase1/PRC1.

  • Open Access
    Growth and toxicity of Halomicronema metazoicum (Cyanoprokaryota, Cyanophyta) at different conditions of light, salinity and temperature
    Mirko Mutalipassi, Valerio Mazzella, Giovanna Romano, Nadia Ruocco, Maria Costantini, Francesca Glaviano, Valerio Zupo
    Biology Open 2019 8: bio043604 doi: 10.1242/bio.043604 Published 24 October 2019

    Summary: This is a contribution to understand toxigenic relationships between cyanobacteria and invertebrates because such interactions, still largely unexplored, may dramatically influence the ecology of several species associated with seagrass ecosystems.

  • Open Access
    Cellular response to bacterial infection in the grasshopper Oxya chinensis
    Xiaomin Zhang, Keshi Zhang
    Biology Open 2019 8: bio045864 doi: 10.1242/bio.045864 Published 22 October 2019

    Summary: We examined the cellular response of Oxya chinensis against bacterial challenges. We showed that two types of haemocytes shared the duty of phagocytosis.

  • Open Access
    Heparan sulfate negatively regulates intestinal stem cell proliferation in Drosophila adult midgut
    Hubing Ma, Huiqing Zhao, Fuli Liu, Hang Zhao, Ruiyan Kong, Lin Shi, Min Wei, Zhouhua Li
    Biology Open 2019 8: bio047126 doi: 10.1242/bio.047126 Published 18 October 2019

    Summary: Heparan sulfate chains in Drosophila adult intestinal stem cells negatively regulate stem cell proliferation and differentiation to control tissue homeostasis under physiological conditions.

  • Open Access
    Long non-coding RNA SNHG1 indicates poor prognosis and facilitates disease progression in acute myeloid leukemia
    Ming Tian, Wanjun Gong, Jingming Guo
    Biology Open 2019 8: bio046417 doi: 10.1242/bio.046417 Published 18 October 2019

    Summary: Long non-coding RNA SNHG1 can facilitate the progression of acute myeloid leukemia by targeting an anti-tumor miR-101, and the upregulation of SNHG1 can predict poor prognosis in acute myeloid leukemia.

  • Open Access
    Acid sphingomyelinase regulates the localization and trafficking of palmitoylated proteins
    Xiahui Xiong, Chia-Fang Lee, Wenjing Li, Jiekai Yu, Linyu Zhu, Yongsoon Kim, Hui Zhang, Hong Sun
    Biology Open 2019 8: bio040311 doi: 10.1242/bio.040311 Published 17 October 2019

    Summary: Acid sphingomyelinase (ASM) regulates palmitoylated protein trafficking and localization.

  • Open Access
    Heterogeneous beta-catenin activation is sufficient to cause hepatocellular carcinoma in zebrafish
    Sharanya M. Kalasekar, Srishti Kotiyal, Christopher Conley, Cindy Phan, Annika Young, Kimberley J. Evason
    Biology Open 2019 8: bio047829 doi: 10.1242/bio.047829 Published 17 October 2019

    Summary: Here we show that expression of activated β-catenin in a subset of early hepatocytes is sufficient to drive liver tumorigenesis. Heterogeneity in β-catenin activation continues during HCC progression.

  • Open Access
    Endurance exercise resistance to lipotoxic cardiomyopathy is associated with cardiac NAD+/dSIR2/PGC-1α pathway activation in old Drosophila
    Deng-Tai Wen, Lan Zheng, Jin-xiu Li, Dan Cheng, Yang Liu, Kai Lu, Wen-qi Hou
    Biology Open 2019 8: bio044719 doi: 10.1242/bio.044719 Published 17 October 2019

    Summary: Exercise training prevents lipotoxic cardiomyopathy induced by a high-fat diet or cardiac dSir2 knockdown in old Drosophila.

  • Open Access
    Restriction of mitochondrial calcium overload by mcu inactivation renders a neuroprotective effect in zebrafish models of Parkinson's disease
    Smijin K. Soman, Michal Bazała, Marcus Keatinge, Oliver Bandmann, Jacek Kuznicki
    Biology Open 2019 8: bio044347 doi: 10.1242/bio.044347 Published 15 October 2019

    Summary: Mitochondrial calcium overload causes mitochondrial dysfunction in Parkinson's disease. Inactivation of mitochondrial calcium uniporter reverses mitochondrial calcium overload and rescues dopaminergic neurons in our zebrafish models of Parkinson's disease.

  • Open Access
    Targeting of copper-trafficking chaperones causes gene-specific systemic pathology in Drosophila melanogaster: prospective expansion of mutational landscapes that regulate tumor resistance to cisplatin
    Eleni I. Theotoki, Athanassios D. Velentzas, Stamatia A. Katarachia, Nikos C. Papandreou, Nikolas I. Kalavros, Sofia N. Pasadaki, Aikaterini F. Giannopoulou, Panagiotis Giannios, Vassiliki A. Iconomidou, Eumorphia G. Konstantakou, Ema Anastasiadou, Issidora S. Papassideri, Dimitrios J. Stravopodis
    Biology Open 2019 8: bio046961 doi: 10.1242/bio.046961 Published 15 October 2019

    Summary: We demonstrate the essential roles of Atox1 and CCS copper-trafficking chaperones in Drosophila development and aging. We also provide insights for their therapeutic exploitation as cisplatin regulators during cancer chemotherapy.

  • Open Access
    Luminal-contact-inhibition of epithelial basal stem cell multipotency in prostate organogenesis and homeostasis
    Corrigan Horton, Yueli Liu, Chuan Yu, Qing Xie, Zhu A. Wang
    Biology Open 2019 8: bio045724 doi: 10.1242/bio.045724 Published 1 October 2019

    Summary: Lineage tracing shows that ablation of prostate luminal cells reactivates adult basal cell multipotency, while luminal–basal cell contact inhibits basal stem cell activities in organoids.

METHODS & TECHNIQUES

  • Open Access
    Computational analysis of size, shape and structure of insect wings
    Mary K. Salcedo, Jordan Hoffmann, Seth Donoughe, L. Mahadevan
    Biology Open 2019 8: bio040774 doi: 10.1242/bio.040774 Published 18 October 2019

    Summary: We provide a set of simple quantitative measures to compare morphological variation in size, shape, and structure of insect wings across species, families and orders.

FIRST PERSON

  • Open Access
    First person – Mary Salcedo
    Biology Open 2019 8: bio048199 doi: 10.1242/bio.048199 Published 18 October 2019
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  • Open Access

    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
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  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
    PDF
  • Open Access

    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
    PDF
  • Open Access

    Conditional targeting of phosphatidylserine decarboxylase to lipid droplets

    Santosh Kumar, Chandramohan Chitraju, Robert Farese, Tobias Walther, Christopher G. Burd
    PDF
  • Open Access

    The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)

    Kun Guo, Jun Zhong, Lin Zhu, Fan Xie, Yu Du, Xiang Ji
    PDF
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