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  You have access

  Open access

March, 2019; 8 (3)

RESEARCH ARTICLES

  • Open Access
    Alteration of 28S rRNA 2′-O-methylation by etoposide correlates with decreased SMN phosphorylation and reduced Drosha levels
    Marilyn F. Burke, Douglas M. McLaurin, Madelyn K. Logan, Michael D. Hebert
    Biology Open 2019 8: bio041848 doi: 10.1242/bio.041848 Published 27 March 2019

    Summary: Our findings support a role for SMN and Drosha in regulating rRNA modification, possibly by affecting snoRNP or regulatory RNP activity, and demonstrate that etoposide impacts rRNA modification.

  • Open Access
    The 1ALCTL and 1BLCTL isoforms of Arg/Abl2 induce fibroblast activation and extra cellular matrix remodelling differently
    Barbara Torsello, Sofia De Marco, Silvia Bombelli, Elisa Chisci, Valeria Cassina, Roberta Corti, Davide Bernasconi, Roberto Giovannoni, Cristina Bianchi, Roberto A. Perego
    Biology Open 2019 8: bio038554 doi: 10.1242/bio.038554 Published 27 March 2019

    Summary: The non-receptor tyrosine kinase Arg and its isoforms modulate the extra cellular matrix production that is relevant in fibrosis and tumour growth, this may open future novel therapeutic approaches.

  • Open Access
    Sperm-duct gland content increases sperm velocity in the sand goby
    Leon Green, Charlotta Kvarnemo
    Biology Open 2019 8: bio037994 doi: 10.1242/bio.037994 Published 27 March 2019

    Summary: In sperm, velocity is often traded off for viability. However, we show here that in sand gobies, sperm-duct gland content increase velocity without reducing viability, thus mitigating such a trade-off.

  • Open Access
    Transcriptomic analyses highlight the likely metabolic consequences of colonization of a cnidarian host by native or non-native Symbiodinium species
    Mei-Fang Lin, Shunichi Takahashi, Sylvain Forêt, Simon K. Davy, David J. Miller
    Biology Open 2019 8: bio038281 doi: 10.1242/bio.038281 Published 27 March 2019

    Summary: Colonization by the homologous symbiont, Symbiodinium goreaui, resulted in greater glycogen synthesis and ammonium assimilation capacity in the host than when it was colonized by a heterologous symbiont (S. trenchii).

  • Open Access
    Sonic hedgehog expression in the postnatal brain
    Aileen Rivell, Ronald S. Petralia, Ya-Xian Wang, Ellie Clawson, Keelin Moehl, Mark P. Mattson, Pamela J. Yao
    Biology Open 2019 8: bio040592 doi: 10.1242/bio.040592 Published 26 March 2019

    Summary: Endogenous Sonic hedgehog protein in the hippocampus is undetectable at birth but increases continuously during postnatal development and remains at readily detectable levels in the mature brain.

  • Open Access
    Independent and combined effects of daytime heat stress and night-time recovery determine thermal performance
    Chun-Ming Bai, Gang Ma, Wan-Zhi Cai, Chun-Sen Ma
    Biology Open 2019 8: bio038141 doi: 10.1242/bio.038141 Published 26 March 2019

    Summary: Daytime and night-time temperatures that organisms experience in fluctuating environments can determine thermal performance and have implications for predicting the impacts of diel asymmetric warming under climate change.

  • Open Access
    Jagged1 protein processing in the developing mammalian lens
    Mina Azimi, Nadean L. Brown
    Biology Open 2019 8: bio041095 doi: 10.1242/bio.041095 Published 26 March 2019

    Summary: The Notch pathway ligand protein Jagged1 undergoes multiple catalytic cleavages, regulated by Adam proteases and the gamma-secretase complex, during mammalian lens development, similar to Notch receptor proteins.

  • Open Access
    Serum-based inhibition of pitviper venom by eastern indigo snakes (Drymarchon couperi)
    Scott M. Goetz, Sara Piccolomini, Michelle Hoffman, James Bogan, Matthew L. Holding, Mary T. Mendonça, David A. Steen
    Biology Open 2019 8: bio040964 doi: 10.1242/bio.040964 Published 26 March 2019

    Summary: We confirm eastern indigo snakes possess a physiological resistance to pitviper venom and speculate that venom resistance in snakes may be a product of antagonistic interactions and phylogenetically conserved traits.

  • Open Access
    Infective larvae of Anisakis simplex (Nematoda) accumulate trehalose and glycogen in response to starvation and temperature stress
    Elżbieta Łopieńska-Biernat, Robert Stryiński, Małgorzata Dmitryjuk, Barbara Wasilewska
    Biology Open 2019 8: bio040014 doi: 10.1242/bio.040014 Published 21 March 2019

    Summary: Carbohydrate metabolism in L3 of A. simplex is affected by temperature shock and by starvation. The metabolic shift from glycogen to trehalose suggests that blocking or silencing the trehalose synthesis pathway could be a limiting factor for Anisakis life and development.

  • Open Access
    Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate
    Kyle A. Wegner, Vatsal Mehta, Jeanette A. Johansson, Brett R. Mueller, Kimberly P. Keil, Lisa L. Abler, Paul C. Marker, M. Mark Taketo, Denis J. Headon, Chad M. Vezina
    Biology Open 2019 8: bio037945 doi: 10.1242/bio.037945 Published 18 March 2019

    Summary: This study provides a rare connection between beta catenin and ectodysplasin A receptor in an endoderm derived tissue and presents a potential mechanism for collagen accumulation in the prostate.

  • Open Access
    Odd-skipped and Stripe act downstream of Notch to promote the morphogenesis of long appendicular tendons in Drosophila
    Lilia Laddada, Krzysztof Jagla, Cédric Soler
    Biology Open 2019 8: bio038760 doi: 10.1242/bio.038760 Published 18 March 2019

    Summary: In this paper, we show that Notch promotes the tendon development by inducing Stripe expression in leg discs and that both Stripe and Odd-skipped are required to form tube-like tendons.

  • Open Access
    The Toxoplasma gondii dense granule protein TgGRA3 interacts with host Golgi and dysregulates anterograde transport
    Maika S. Deffieu, Tchilabalo Dilezitoko Alayi, Christian Slomianny, Stanislas Tomavo
    Biology Open 2019 8: bio039818 doi: 10.1242/bio.039818 Published 18 March 2019

    Summary : Toxoplasma gondii recruits various host organelles to enable parasite intracellular development. We describe a new role for TgGRA3 in modulating the host anterograde transport by binding to the Golgi apparatus.

  • Open Access
    Mbt/PAK4 together with SRC modulates N-Cadherin adherens junctions in the developing Drosophila eye
    Stephanie M. Pütz
    Biology Open 2019 8: bio038406 doi: 10.1242/bio.038406 Published 18 March 2019

    Summary: N-Cadherin adherens junction formation in the Drosophila larval eye imaginal disc is controlled by the combined functions of the p21-activated kinase Mbt/PAK4 and the kinases Src64 and Src42.

  • Open Access
    Identification of possible hypoxia sensor for behavioral responses in a marine annelid, Capitella teleta
    Tetsuya Ogino, Haruhiko Toyohara
    Biology Open 2019 8: bio037630 doi: 10.1242/bio.037630 Published 14 March 2019

    Summary: The hypoxia-avoidance behavior of a marine annelid was suppressed by a TRPA1-specific inhibitor. Our dataset suggests that the possible hypoxia sensor for hypoxia-inducing behaviors of this marine annelid is TRPAbasal.

  • Open Access
    Reprogramming of the cambium regulators during adventitious root development upon wounding of storage tap roots in radish (Raphanus sativus L.)
    Ana Cecilia Aliaga Fandino, Hyoujin Kim, Jesse David Rademaker, Ji-Young Lee
    Biology Open 2019 8: bio039677 doi: 10.1242/bio.039677 Published 12 March 2019

    Summary: Adventitious roots originate from cambia of cut radish taproots. This process depends on the auxin-dependent reprogramming of cambial regulators and the activation of canonical adventitious root regulators.

  • Open Access
    Escort cell encapsulation of Drosophila germline cells is maintained by irre cell recognition module proteins
    Doreen S. Ben-Zvi, Talila Volk
    Biology Open 2019 8: bio039842 doi: 10.1242/bio.039842 Published 5 March 2019

    Statement: IRM proteins mediate adhesion between escort cells and the germline cells, promoting short range signaling required for escort cells’ encapsulation of germline cells.

  • Open Access
    The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating
    Anke Ziska, Jörg Tatzelt, Johanna Dudek, Adrienne W. Paton, James C. Paton, Richard Zimmermann, Sarah Haßdenteufel
    Biology Open 2019 8: bio040691 doi: 10.1242/bio.040691 Published 5 March 2019

    Summary: We present a hitherto overlooked polybasic motif as functional domain in the early mature region of prion protein which interferes with ER import and requires compensation by chaperone-mediated Sec61 gating.

  • Open Access
    Chromogranin A regulates neuroblastoma proliferation and phenotype
    Dongyun Zhang, Lilit Babayan, Hillary Ho, Anthony P. Heaney
    Biology Open 2019 8: bio036566 doi: 10.1242/bio.036566 Published 4 March 2019

    Summary: Loss of CgA directs neuroblastoma differentiation toward S-type, which synergize the anti-proliferative effects of AKT/MEK inhibitors, suggesting a novel treatment direction.

  • Open Access
    De novo transcription of multiple Hox cluster genes takes place simultaneously in early Xenopus tropicalis embryos
    Mariko Kondo, Megumi Matsuo, Kento Igarashi, Yoshikazu Haramoto, Takayoshi Yamamoto, Yuuri Yasuoka, Masanori Taira
    Biology Open 2019 8: bio038422 doi: 10.1242/bio.038422 Published 4 March 2019

    Summary: qPCR analysis for de novo transcription of hox genes suggest that temporal collinearity is not held for all hox genes during early development of Xenopus tropicalis.

  • Open Access
    Mutation of microphthalmia-associated transcription factor (mitf) in zebrafish sensitizes for glomerulopathy
    Janina Müller-Deile, Heiko Schenk, Philipp Niggemann, Patricia Bolaños-Palmieri, Beina Teng, Alysha Higgs, Lynne Staggs, Hermann Haller, Patricia Schroder, Mario Schiffer
    Biology Open 2019 8: bio040253 doi: 10.1242/bio.040253 Published 4 March 2019

    Summary: We discovered that the mitf mutation, causative for nacre-albinism mutation in zebrafish, sensitizes for glomerulopathy-induced by puromycin aminonucleoside (PAN) and developed a fish water treatment-model for anti-proteinuric drug screenings.

METHODS & TECHNIQUES

  • Open Access
    Automated morphometry toolbox for analysis of microscopic model organisms using simple bright-field imaging
    Guanghui Liu, Fenfen Dong, Chuanhai Fu, Zachary J. Smith
    Biology Open 2019 8: bio037788 doi: 10.1242/bio.037788 Published 12 March 2019

    Summary: We demonstrate a robust algorithm to count and extract morphology of model organisms, including shape-variant mutants, enabling measurements of large numbers of individuals without substantial time or labor.

  • Open Access
    Sea urchin Paracentrotus lividus immune cells in culture: formulation of the appropriate harvesting and culture media and maintenance conditions
    Annalisa Pinsino, Andi Alijagic
    Biology Open 2019 8: bio039289 doi: 10.1242/bio.039289 Published 5 March 2019

    Summary: Appropriate culture methods for sea urchin immune cells provide an invaluable and amenable model for answering immunological questions while limiting the use of mammalian organisms.

FIRST PERSON

  • Open Access
    First person – Leon Green
    Biology Open 2019 8: bio043141 doi: 10.1242/bio.043141 Published 27 March 2019
  • Open Access
    First person – Barbara Torsello
    Biology Open 2019 8: bio043000 doi: 10.1242/bio.043000 Published 27 March 2019
  • Open Access
    First person – Mei-Fang Lin
    Biology Open 2019 8: bio042507 doi: 10.1242/bio.042507 Published 27 March 2019
  • Open Access
    First person – Kyle Wegner
    Biology Open 2019 8: bio042333 doi: 10.1242/bio.042333 Published 18 March 2019
  • Open Access
    First person – Maika S. Deffieu
    Biology Open 2019 8: bio042499 doi: 10.1242/bio.042499 Published 18 March 2019
  • Open Access
    First person – Ana Cecilia Aliaga Fandino
    Biology Open 2019 8: bio042556 doi: 10.1242/bio.042556 Published 13 March 2019
  • Open Access
    First person – Sarah Haßdenteufel
    Biology Open 2019 8: bio042549 doi: 10.1242/bio.042549 Published 6 March 2019
  • Open Access
    First person – Annalisa Pinsino and Andi Alijagic
    Biology Open 2019 8: bio042242 doi: 10.1242/bio.042242 Published 6 March 2019
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  • Open Access

    Integrated Analysis of Cell Shape and Movement in Moving Frame

    Yusri Dwi Heryanto, Chin-Yi Cheng, Yutaka Uchida, Kazushi Mimura, Masaru Ishii, Ryo Yamada
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  • Open Access

    Avoiding being stung or bitten – prey capture behaviors of the ant-eating Texas horned lizard (Phrynosoma cornutum)

    Ismene Fertschai, Wade C. Sherbrooke, Matthias Ott, Boris P. Chagnaud
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  • Open Access

    A Zebrafish Forward Genetic Screen Identifies an Indispensible Threonine Residue in the Kinase Domain of PRKD2

    Panagiota Giardoglou, Despina Bournele, Misun Park, Stavroula Kanoni, George V. Dedoussis, Susan F. Steinberg, Panos Deloukas, Dimitris Beis
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    Interdomain interactions regulate the localization of a lipid transfer protein at ER-PM contact sites

    Bishal Basak, Harini Krishnan, Raghu Padinjat
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  • Open Access

    The thermal dependence and molecular basis of physiological color change in Takydromus septentrionalis (Lacertidae)

    Kun Guo, Jun Zhong, Lin Zhu, Fan Xie, Yu Du, Xiang Ji
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