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  You have access

  Open access

May, 2019; 8 (5)

RESEARCH ARTICLES

  • Open Access
    Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster
    Jessica R. Blount, Danielle N. Meyer, Camille Akemann, Sean L. Johnson, Katherine Gurdziel, Tracie R. Baker, Sokol V. Todi
    Biology Open 2019 8: bio043372 doi: 10.1242/bio.043372 Published 30 May 2019

    Summary: Our Drosophila studies indicate the lack of a marked, coordinated response towards unanchored poly-ubiquitin in flies, suggesting that untethered ubiquitin chains are not necessarily problematic in intact organisms.

  • Open Access
    Re-evaluation of the causes of variation among mouse aggregation chimaeras
    John D. West, Pin-Chi Tang, Clare A. Everett, Gillian E. MacKay, Jean H. Flockhart, Margaret A. Keighren
    Biology Open 2019 8: bio042804 doi: 10.1242/bio.042804 Published 30 May 2019

    Summary: Analysis of published results suggests that two stochastic allocation steps in chimaeric mouse blastocysts, without the geometrical sampling mechanism proposed previously, could explain much of the variation among aggregation chimaeras.

  • Open Access
    Numb regulates cell tension required for mammary duct elongation
    Sudipa June Chatterjee, Ruba Halaoui, Rebecca Catherine Deagle, Carlis Rejon, Luke McCaffrey
    Biology Open 2019 8: bio042341 doi: 10.1242/bio.042341 Published 30 May 2019

    Summary: Numb regulates cortical cell tension, which is necessary to maintain proper cell shape and packing density during mammary duct elongation.

  • Open Access
    The optimal mechanical condition in stem cell-to-tenocyte differentiation determined with the homogeneous strain distributions and the cellular orientation control
    Yasuyuki Morita, Toshihiro Sato, Kouji Higashiura, Yusho Hirano, Fuga Matsubara, Kanau Oshima, Koji Niwa, Yuhki Toku, Guanbin Song, Qing Luo, Yang Ju
    Biology Open 2019 8: bio039164 doi: 10.1242/bio.039164 Published 30 May 2019

    Summary: We determined the relationship between the cyclic strain of culture membrane and cellular gene expression, from which the most effective strain for tenogenic differentiation of stem cells was elucidated.

  • Open Access
    Cold adaptive potential of pine wood nematodes overwintering in plant hosts
    Zhenkai Liu, Yongxia Li, Long Pan, Fanli Meng, Xingyao Zhang
    Biology Open 2019 8: bio041616 doi: 10.1242/bio.041616 Published 22 May 2019

    Summary: The modifications in fatty acid composition and cryoprotectant levels, as elements of its changing physiology, play important roles in the overwintering success of the pine wood nematode.

  • Open Access
    Physiological and behavioral stress responses to predators are altered by prior predator experience in juvenile qingbo (Spinibarbus sinensis)
    Jia-Jia Xu, Shi-Jian Fu, Cheng Fu
    Biology Open 2019 8: bio041012 doi: 10.1242/bio.041012 Published 22 May 2019

    Summary: A predator-naive carp can recognize its natural predator, and this recognition can be intensified by prior experience with a predator or the presence of a conspecific.

  • Open Access
    Defining the dynamic chromatin landscape of mouse nephron progenitors
    Sylvia Hilliard, Renfang Song, Hongbing Liu, Chao-hui Chen, Yuwen Li, Melody Baddoo, Erik Flemington, Alanna Wanek, Jay Kolls, Zubaida Saifudeen, Samir S. El-Dahr
    Biology Open 2019 8: bio042754 doi: 10.1242/bio.042754 Published 20 May 2019

    Summary: An investigation of the chromatin landscape of mouse nephron progenitors across their life span supports the view that old nephron progenitors are epigenetically poised for differentiation.

  • Open Access
    Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function
    Gareth W. Fearnley, Izma Abdul-Zani, Antony M. Latham, Monica C. Hollstein, John E. Ladbury, Stephen B. Wheatcroft, Adam F. Odell, Sreenivasan Ponnambalam
    Biology Open 2019 8: bio034215 doi: 10.1242/bio.034215 Published 17 May 2019

    Summary: Our study shows that the growth factor VEGF-A stimulates synthesis in endothelial cells of a proto-oncoprotein and protein kinase, Tpl2, and this is required for signal transduction and angiogenesis.

  • Open Access
    Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like response
    Geng-You Liao, Ming-Ting Lee, Jhen-Jia Fan, Pei-Wen Hsiao, Chun-Sheng Lee, Shou-Yi Su, Jiuan-Jiuan Hwang, Ferng-Chun Ke
    Biology Open 2019 8: bio038257 doi: 10.1242/bio.038257 Published 17 May 2019

    Summary: Glutamine-dependent anaplerosis is essential to cell growth and closely associated with mTORC1 activation and mTORC2 inactivation, and impedes cellular senescence particularly associated with p16INK4A.

  • Open Access
    Dietary iron restriction leads to a reduction in hepatic fibrosis in a rat model of non-alcoholic steatohepatitis
    Naomichi Abe, Takuma Tsuchida, Shin-Ichiro Yasuda, Kozo Oka
    Biology Open 2019 8: bio040519 doi: 10.1242/bio.040519 Published 16 May 2019

    Summary: We reveal that dietary iron restriction leads to a reduction in hepatic inflammation, oxidative stress and fibrosis in rats fed a choline-deficient L-amino acid-defined (CDAA) diet.

  • Open Access
    Quantitative proteomic profiling of tumor-associated vascular endothelial cells in colorectal cancer
    Guoqiang Wang, Qiongzhi Yang, Maoyu Li, Ye Zhang, Yuxiang Cai, Xujun Liang, Ying Fu, Zhefeng Xiao, Minze Zhou, Zhongpeng Xie, Huichao Huang, Yahui Huang, Yongheng Chen, Qiongqiong He, Fang Peng, Zhuchu Chen
    Biology Open 2019 8: bio042838 doi: 10.1242/bio.042838 Published 13 May 2019

    Summary: We provided large-scale proteomic profiling of vascular endothelial cells in colorectal cancer with quantitative information, a number of potential antiangiogenic targets and a novel vision in the angiogenesis bio-mechanism of CRC.

  • Open Access
    Xenotransplantation of Human glioblastoma in Zebrafish larvae: in vivo imaging and proliferation assessment
    Luis A. Vargas-Patron, Nathalie Agudelo-Dueñas, Jorge Madrid-Wolff, Juan A. Venegas, John M. González, Manu Forero-Shelton, Veronica Akle
    Biology Open 2019 8: bio043257 doi: 10.1242/bio.043257 Published 13 May 2019

    Summary: The combination of light sheet fluorescent microscopy and flow cytometry allows assessment of proliferation and tumor growth of human GBM inside zebrafish, making it a useful model to identify effective anti-proliferative agents in a preclinical setting.

  • Open Access
    Effects of chronic inhibition of Testosterone metabolism on cardiac remodeling after ischemia/reperfusion-induced myocardial damage in gonadectomized rats
    Octavio Maldonado, Angel Ramos, Mario Guapillo, Jose Rivera, Icela Palma, Ivan Rubio-Gayosso, Israel Ramirez-Sanchez, Nayelli Najera, Guillermo Ceballos, Enrique Mendez-Bolaina
    Biology Open 2019 8: bio041905 doi: 10.1242/bio.041905 Published 13 May 2019

    Summary: Coronary ischemia/reperfusion-induced injury in gonadectomyzed male rats is decreased by testosterone, protection is increased by blocking its 5α-reduction and blocked by inhibition of its aromatization.

  • Open Access
    Pioglitazone abolishes cognition impairments as well as BDNF and neurotensin disturbances in a rat model of autism
    Thiago B. Kirsten, Renato C. Casarin, Maria M. Bernardi, Luciano F. Felicio
    Biology Open 2019 8: bio041327 doi: 10.1242/bio.041327 Published 13 May 2019

    Summary: Exposure of rats to lipopolysaccharide during gestation induced autistic-like behaviors in the juvenile offspring. Daily postnatal pioglitazone treatment abolished cognition impairments as well as brain-derived neurotrophic factor and neurotensin disturbances.

  • Open Access
    Meiosis in the scorpion Tityus silvestris: new insights into achiasmatic chromosomes
    Bruno Rafael Ribeiro de Almeida, Renata Coelho Rodrigues Noronha, Marlyson Jeremias Rodrigues da Costa, Cleusa Yoshiko Nagamachi, Julio Cesar Pieczarka
    Biology Open 2019 8: bio040352 doi: 10.1242/bio.040352 Published 13 May 2019

    Summary: The scorpion Tityus silvestris, despite not presenting chiasma, performs initial stages of the recombination process and maintains the homologues synapse and different epigenetic modifications until late stages of meiosis I.

  • Open Access
    Karyoevolution of Crenicichla heckel 1840 (Cichlidae, Perciformes): a process mediated by inversions
    Luan Felipe da Silva Frade, Bruno Rafael Ribeiro de Almeida, Susana Suely Rodrigues Milhomem-Paixão, Jonathan Stuart Ready, Cleusa Yoshiko Nagamachi, Julio Cesar Pieczarka, Renata Coelho Rodrigues Noronha
    Biology Open 2019 8: bio041699 doi: 10.1242/bio.041699 Published 9 May 2019

    Summary: This paper has a great importance for understanding karyotype evolutionary dynamics in neotropical freshwater fish, focusing on repetitive DNA and the role of inversions in Crenicichla.

  • Open Access
    Longitudinal characterization of diet-induced genetic murine models of non-alcoholic steatohepatitis with metabolic, histological, and transcriptomic hallmarks of human patients
    Naomichi Abe, Sayuka Kato, Takuma Tsuchida, Kanami Sugimoto, Ryuta Saito, Lars Verschuren, Robert Kleemann, Kozo Oka
    Biology Open 2019 8: bio041251 doi: 10.1242/bio.041251 Published 1 May 2019

    Summary: We revealed that ob/ob mice under fast food diet (FFD) regime develop metabolic, histological and transcriptomic dysfunctions similar to human non-alcoholic steatohepatitis (NASH).

  • Open Access
    Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy
    Zhanying Hu, Bo Chen, Qiong Zhao
    Biology Open 2019 8: bio040840 doi: 10.1242/bio.040840 Published 1 May 2019

    Summary: Our report of an essential regulation role of hedgehog signaling and autophagy on osteoblast differentiation may contribute to research on bone development biology, hedgehog signaling and the autophagy pathway.

  • Open Access
    Exosomal transfer of bone marrow mesenchymal stem cell-derived miR-340 attenuates endometrial fibrosis
    Bang Xiao, Yiqing Zhu, Jinfeng Huang, Tiantian Wang, Fang Wang, Shuhan Sun
    Biology Open 2019 8: bio039958 doi: 10.1242/bio.039958 Published 1 May 2019

    Summary: miR-340 in the exosomes released from BMSCs are transferred to endometrial cells, which regulate gene expression, repress endometrial fibrosis and promote functional recovery in rats subjected to mechanical damage.

  • Open Access
    Physiological profile of undifferentiated bovine blastocyst-derived trophoblasts
    Viju Vijayan Pillai, Luiz G. Siqueira, Moubani Das, Tiffany G. Kei, Lan N. Tu, Anthony W. Herren, Brett S. Phinney, Soon Hon Cheong, Peter J. Hansen, Vimal Selvaraj
    Biology Open 2019 8: bio037937 doi: 10.1242/bio.037937 Published 1 May 2019

    Summary: Fundamental physiology of the bovine trophectoderm and hallmarks of the self-renewing undifferentiated ‘trophoblast stem cells’ are interpreted through systematic analysis of the cellular proteome and transcriptome.

  • Open Access
    Intercellular transfer of P-glycoprotein mediates the formation of stable multi-drug resistance in human bladder cancer BIU-87 cells
    Xiao-Zhi Cheng, Hui-Liang Zhou, Song-Xi Tang, Tao Jiang, Qin Chen, Rui Gao, Yi-Lang Ding
    Biology Open 2019 8: bio041889 doi: 10.1242/bio.041889 Published 1 May 2019

    Summary: Intercellular transfer of P-glycoprotein forms stable multi-drug resistance, which complements the formation mechanism of MDR and indicates that new treatment strategies need to be designed to overcome MDR.

METHODS AND TECHNIQUES

  • Open Access
    SuperCLEM: an accessible correlative light and electron microscopy approach for investigation of neurons and glia in vitro
    Daniel G. Booth, Alison J. Beckett, Ian A. Prior, Dies Meijer
    Biology Open 2019 8: bio042085 doi: 10.1242/bio.042085 Published 30 May 2019

    Summary: We developed an advanced, accessible and adaptable correlative light and electron microscopy pipeline for study of neuron-glia cultures and demonstrate its power by deriving accurate 3D models of myelinated axons.

  • Open Access
    Beyond the whole-mount phenotype: high-resolution imaging in fluorescence-based applications on zebrafish
    Veronika Oralová, Joana T. Rosa, Mieke Soenens, Jan Willem Bek, Andy Willaert, Paul Eckhard Witten, Ann Huysseune
    Biology Open 2019 8: bio042374 doi: 10.1242/bio.042374 Published 24 May 2019

    Summary: We propose a GMA embedding method that preserves fluorescent signals without the need for antibodies. The method complements whole-mount methods especially if advanced imaging technology is not readily available.

  • Open Access
    Detection of changes in mitochondrial hydrogen sulfide in vivo in the fish model Poecilia mexicana (Poeciliidae)
    Gigi Y. Lau, Nicholas Barts, Richard C. Hartley, Michael Tobler, Jeffrey G. Richards, Michael P. Murphy, Sabine Arndt
    Biology Open 2019 8: bio041467 doi: 10.1242/bio.041467 Published 9 May 2019

    Summary: We established the mitochondria-targeted mass spectrometry probe MitoA for H2S detection in vivo in the animal model Poecilia mexicana for the first time.

  • Open Access
    High-yield isolation of menstrual blood-derived endometrial stem cells by direct red blood cell lysis treatment
    Yuliang Sun, Yakun Ren, Fen Yang, Yanan He, Shengying Liang, Lihong Guan, Fangfang Cheng, Yanli Liu, Juntang Lin
    Biology Open 2019 8: bio038885 doi: 10.1242/bio.038885 Published 2 May 2019

    Summary: MenSC isolation by directly lysing the red blood cells not only guarantees substantial amounts of superior MenSCs with low passage number, but also is time efficient and economical.

FIRST PERSON

  • Open Access
    First person – Gigi Lau and Nick Barts
    Biology Open 2019 8: bio044321 doi: 10.1242/bio.044321 Published 9 May 2019
  • Open Access
    First person – Xiao-Zhi Cheng
    Biology Open 2019 8: bio043752 doi: 10.1242/bio.043752 Published 1 May 2019
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  • Open Access

    Notch signaling governs the expression of glypican Dally to define the stem cell niche

    Songhua Zhao, Chan Wu, Zhiyang Gao, Xin Li, Guo Zheng, Zhaohui Wang
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  • Open Access

    Visualisation of ribosomes in Drosophila axons using Ribo-BiFC

    Anand K. Singh, Akilu Abdullahi, Matthias Soller, Alexandre David, Saverio Brogna
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  • Open Access

    Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease

    Juan Garrido-Maraver, Samantha H. Y. Loh, L. Miguel Martins
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  • Open Access

    Larval mannitol diets increase mortality, prolong development, and decrease adult body sizes in fruit flies (Drosophila melanogaster)

    Meghan Barrett, Katherine Fiocca, Edward A. Waddell, Cheyenne McNair, Sean O'Donnell, Daniel R. Marenda
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  • Open Access

    The interconnection between cytokeratin and cell membrane-bound β-catenin in Sertoli cells derived from juvenile Xenopus tropicalis testes

    Thi Minh Xuan Nguyen, Marketa Vegrichtova, Tereza Tlapakova, Magdalena Krulova, Vladimir Krylov
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