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Research Article
Longitudinal characterization of diet-induced genetic murine models of non-alcoholic steatohepatitis with metabolic, histological, and transcriptomic hallmarks of human patients
Naomichi Abe, Sayuka Kato, Takuma Tsuchida, Kanami Sugimoto, Ryuta Saito, Lars Verschuren, Robert Kleemann, Kozo Oka
Biology Open 2019 8: bio041251 doi: 10.1242/bio.041251 Published 1 May 2019
Naomichi Abe
1Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda-shi, Saitama 335-8505, Japan
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  • ORCID record for Naomichi Abe
  • For correspondence: Abe.Naomichi@me.mt-pharma.co.jp
Sayuka Kato
1Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda-shi, Saitama 335-8505, Japan
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Takuma Tsuchida
1Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda-shi, Saitama 335-8505, Japan
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Kanami Sugimoto
1Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda-shi, Saitama 335-8505, Japan
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Ryuta Saito
1Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda-shi, Saitama 335-8505, Japan
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Lars Verschuren
2Department of Microbiology and Systems Biology, Netherlands Organization for Applied Scientific Research (TNO), Utrechtseweg 48, 3700 AJ, Zeist, The Netherlands
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Robert Kleemann
3Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO), Zernikedreef 9, 2301 CE, Leiden, the Netherlands
4Department of Vascular Surgery, Netherlands Organization for Applied Scientific Research (TNO), Albinusdreef 2, P.O.Box 9600, 2333 ZA Leiden, The Netherlands
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Kozo Oka
1Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda-shi, Saitama 335-8505, Japan
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Article Information

vol. 8 no. 5, bio041251

DOI 
https://doi.org/10.1242/bio.041251
PubMed 
31023717

Published By 
The Company of Biologists Ltd
Online ISSN 
2046-6390
History 
  • Received December 23, 2018
  • Accepted April 10, 2019
  • Published online May 1, 2019.
Posted online 
April 25, 2019
Copyright & Usage 
© 2019. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Article Versions

  • Previous version (April 25, 2019 - 03:33).
  • You are viewing the most recent version of this article.

Author Information

  1. Naomichi Abe1,*,
  2. Sayuka Kato1,
  3. Takuma Tsuchida1,
  4. Kanami Sugimoto1,
  5. Ryuta Saito1,
  6. Lars Verschuren2,
  7. Robert Kleemann3,4 and
  8. Kozo Oka1
  1. 1Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda-shi, Saitama 335-8505, Japan
  2. 2Department of Microbiology and Systems Biology, Netherlands Organization for Applied Scientific Research (TNO), Utrechtseweg 48, 3700 AJ, Zeist, The Netherlands
  3. 3Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO), Zernikedreef 9, 2301 CE, Leiden, the Netherlands
  4. 4Department of Vascular Surgery, Netherlands Organization for Applied Scientific Research (TNO), Albinusdreef 2, P.O.Box 9600, 2333 ZA Leiden, The Netherlands
  1. ↵*Author for correspondence (Abe.Naomichi{at}me.mt-pharma.co.jp)

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Keywords

  • Fast food
  • Fibrosis
  • Non-alcoholic steatohepatitis
  • Hyperinsulinemia
  • Obesity

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Research Article
Longitudinal characterization of diet-induced genetic murine models of non-alcoholic steatohepatitis with metabolic, histological, and transcriptomic hallmarks of human patients
Naomichi Abe, Sayuka Kato, Takuma Tsuchida, Kanami Sugimoto, Ryuta Saito, Lars Verschuren, Robert Kleemann, Kozo Oka
Biology Open 2019 8: bio041251 doi: 10.1242/bio.041251 Published 1 May 2019
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Research Article
Longitudinal characterization of diet-induced genetic murine models of non-alcoholic steatohepatitis with metabolic, histological, and transcriptomic hallmarks of human patients
Naomichi Abe, Sayuka Kato, Takuma Tsuchida, Kanami Sugimoto, Ryuta Saito, Lars Verschuren, Robert Kleemann, Kozo Oka
Biology Open 2019 8: bio041251 doi: 10.1242/bio.041251 Published 1 May 2019

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