Article Figures & Tables
Figures
- Fig. 1.
Effect induced by the inhibition of testosterone metabolism. Testosterone modifies the percentage of tissue damage by the coronary I/R process in ORX rats. The ORX rats were treated subcutaneously every 72 h for 30 days after cardiac damage induced by the coronary I/R process, with exogenous testosterone (T), Finasteride (Finas), 4-OHA or a combination of both inhibitors. Representative images of heart sections are shown at the top of each bar. Image X4. The data are expressed as the mean±s.e.m. of the percentage of the AI/AT ratio of five hearts per group, *P<0.05, δδP<0.01, ***P<0.005, δδδP<0.001.
- Fig. 2.
Quantitative analysis of cellular infiltration (blue spots) in cardiac tissue subjected to coronary I/R in ORX rats. Exogenous testosterone administration, Finas, 4-OHA or a combination of both inhibitors were administered subcutaneously every 72 h for 30 days after ischemic damage. The analysis was performed in three sections of each heart per group (n=5) using the ImageJ program. The data are expressed as the mean±s.e.m. Representative images of cellular infiltration are observed through Hematoxylin-Eosin staining (top panels). Scale bars: 100 μm. *P<0.01, δP<0.05, ***P<0.001.
- Fig. 3.
Quantitative analysis of MMP-3 and MMP-13 expression. Upper panel: MMP-3 expression in cardiac tissue subjected to coronary I/R in ORX rats. Lower panel: MMP-13 expression in cardiac tissue subjected to coronary I/R in ORX rats. Rats were treated subcutaneously with exogenous testosterone, Finas, and/or 4-OHA every 72 h for 30 days after ischemic damage. The micrographs show representative images of the immunohistochemical analysis performed on five sections of each heart per group (n=5). The data are expressed as the mean±s.e.m. *P<0.01, δP<0.05, ***P<0.001, δδP<0.01. Scale bar: 100 μm.
Article Navigation
Related articles
Cited by...
More in this TOC section
Similar articles
Other journals from The Company of Biologists
Biology Open and COVID-19
We are aware that the COVID-19 pandemic is having an unprecedented impact on researchers worldwide. The Editors of all The Company of Biologists’ journals have been considering ways in which we can alleviate concerns that members of our community may have around publishing activities during this time. Read about the actions we are taking at this time.
Please don’t hesitate to contact the Editorial Office if you have any questions or concerns.
New funding scheme supports sustainable events
As part of our Sustainable Conferencing Initiative, we are pleased to announce funding for organisers that seek to reduce the environmental footprint of their event. The next deadline to apply for a Scientific Meeting grant is 26 March 2021.
Future Leader Review – early neurodegeneration of Alzheimer’s disease
A new Future Leader Review from Olayemi Olajide, Marcus Suvanto and Clifton Andrew Chapman evaluates the molecular mechanisms that may explain the vulnerability and susceptibility of the entorhinal cortex to early neurodegeneration during the pathogenesis of Alzheimer's disease.
Find out more about our Future Leader Reviews – they are an exclusive opportunity for early-career researchers who want to establish themselves in their field.
First author interviews
Catch up on our latest first author interviews to go behind the scenes of our latest research, find out more about the authors and hear from early-career researchers themselves how they’re finding life at the bench.
Retinal degeneration in Drosophila
Thank you to Elisabeth Knust and her team for their confocal image of a longitudinal section of an adult Drosophila retina, which brightens the cover of our latest issue. Read the research behind the cover.