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Research Article
An essential role of the mouse synapse-associated protein Syap1 in circuits for spontaneous motor activity and rotarod balance
Cora R. von Collenberg, Dominique Schmitt, Thomas Rülicke, Michael Sendtner, Robert Blum, Erich Buchner
Biology Open 2019 8: bio042366 doi: 10.1242/bio.042366 Published 5 June 2019
Cora R. von Collenberg
1Institute of Clinical Neurobiology, University Hospital Würzburg, Versbacher Str. 5, 97078 Würzburg, Germany
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  • ORCID record for Cora R. von Collenberg
Dominique Schmitt
1Institute of Clinical Neurobiology, University Hospital Würzburg, Versbacher Str. 5, 97078 Würzburg, Germany
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Thomas Rülicke
2Institute of Laboratory Animal Science, University of Veterinary Medicine Vienna, 1210 Vienna, Austria
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Michael Sendtner
1Institute of Clinical Neurobiology, University Hospital Würzburg, Versbacher Str. 5, 97078 Würzburg, Germany
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  • ORCID record for Michael Sendtner
Robert Blum
1Institute of Clinical Neurobiology, University Hospital Würzburg, Versbacher Str. 5, 97078 Würzburg, Germany
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  • ORCID record for Robert Blum
  • For correspondence: Buchner_E@UKW.de Blum_R@UKW.de
Erich Buchner
1Institute of Clinical Neurobiology, University Hospital Würzburg, Versbacher Str. 5, 97078 Würzburg, Germany
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  • ORCID record for Erich Buchner
  • For correspondence: Buchner_E@UKW.de Blum_R@UKW.de
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This article has a correction. Please see:

  • Correction: An essential role of the mouse synapse-associated protein Syap1 in circuits for spontaneous motor activity and rotarod balance - February 15, 2020

ABSTRACT

Synapse-associated protein 1 (Syap1) is the mammalian homologue of synapse-associated protein of 47 kDa (Sap47) in Drosophila. Genetic deletion of Sap47 leads to deficiencies in short-term plasticity and associative memory processing in flies. In mice, Syap1 is prominently expressed in the nervous system, but its function is still unclear. We have generated Syap1 knockout mice and tested motor behaviour and memory. These mice are viable and fertile but display distinct deficiencies in motor behaviour. Locomotor activity specifically appears to be reduced in early phases when voluntary movement is initiated. On the rotarod, a more demanding motor test involving control by sensory feedback, Syap1-deficient mice dramatically fail to adapt to accelerated speed or to a change in rotation direction. Syap1 is highly expressed in cerebellar Purkinje cells and cerebellar nuclei. Thus, this distinct motor phenotype could be due to a so-far unknown function of Syap1 in cerebellar sensorimotor control. The observed motor defects are highly specific since other tests in the modified SHIRPA exam, as well as cognitive tasks like novel object recognition, Pavlovian fear conditioning, anxiety-like behaviour in open field dark-light transition and elevated plus maze do not appear to be affected in Syap1 knockout mice.

Footnotes

  • Competing interests

    The authors declare no competing or financial interests.

  • Author contributions

    Conceptualization: M.S., R.B., E.B.; Methodology: C.R.v.C, D.S., T.R., R.B.; Formal analysis: C.R.v.C.; Investigation: C.R.v.C., D.S.; Resources: T.R., M.S.; Data curation: C.R.v.C., R.B.; Writing - original draft: C.R.v.C., R.B., E.B.; Writing - review & editing: C.R.v.C., D.S., T.R., M.S., R.B., E.B.; Supervision: M.S., R.B., E.B.; Funding acquisition: M.S., R.B., E.B.

  • Funding

    This work was supported by German Research Foundation (DFG) [project number 44541416–TRR58–A10 to R.B. and M.S.]; by the Bundesministerium für Bildung und Forschung [Dystract TP6 to M.S.]; and by the INFRAFRONTIER-I3 project Capacities Specific Programme [EU contract Grant Agreement Number 312325, EC FP7 to E.B.]. This publication was also funded by the DFG and the University of Wuerzburg in the funding programme Open Access Publishing.

  • Supplementary information

    Supplementary information available online at http://bio.biologists.org/lookup/doi/10.1242/bio.042366.supplemental

  • Received February 6, 2019.
  • Accepted May 13, 2019.
  • © 2019. Published by The Company of Biologists Ltd
http://creativecommons.org/licenses/by/4.0

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Keywords

  • Syap1 knockout
  • Motor behaviour
  • Associative learning
  • Fear conditioning
  • Object recognition

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Research Article
An essential role of the mouse synapse-associated protein Syap1 in circuits for spontaneous motor activity and rotarod balance
Cora R. von Collenberg, Dominique Schmitt, Thomas Rülicke, Michael Sendtner, Robert Blum, Erich Buchner
Biology Open 2019 8: bio042366 doi: 10.1242/bio.042366 Published 5 June 2019
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Research Article
An essential role of the mouse synapse-associated protein Syap1 in circuits for spontaneous motor activity and rotarod balance
Cora R. von Collenberg, Dominique Schmitt, Thomas Rülicke, Michael Sendtner, Robert Blum, Erich Buchner
Biology Open 2019 8: bio042366 doi: 10.1242/bio.042366 Published 5 June 2019

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