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Research Article
Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells
Shun Nakai, Ima Shibata, Takahiro Shitamichi, Hiroyuki Yamaguchi, Nobuyuki Takagi, Tomoaki Inoue, Toshito Nakagawa, Jumpei Kiyokawa, Satoshi Wakabayashi, Tomoya Miyoshi, Eriko Higashi, Seiichi Ishida, Nobuaki Shiraki, Shoen Kume
Biology Open 2019 8: bio042192 doi: 10.1242/bio.042192 Published 2 July 2019
Shun Nakai
1School of Life Science and Technology, Tokyo Institute of Technology, 4259-B-25 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan
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Ima Shibata
1School of Life Science and Technology, Tokyo Institute of Technology, 4259-B-25 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan
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Takahiro Shitamichi
1School of Life Science and Technology, Tokyo Institute of Technology, 4259-B-25 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan
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Hiroyuki Yamaguchi
2Isehara Research Laboratory, Technology and Development Division, Kanto Chemical Co., Inc., 21 Suzukawa, Isehara, Kanagawa 259-1146, Japan
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Nobuyuki Takagi
3Technology and Development Division, Kanto Chemical Co., Inc., 2-1, Nihonbashi Muromachi 2-chome, Chuo-ku, Tokyo 103-0022, Japan
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Tomoaki Inoue
4Research Division, Chugai Pharmaceutical Co. Ltd, 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan
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Toshito Nakagawa
4Research Division, Chugai Pharmaceutical Co. Ltd, 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan
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Jumpei Kiyokawa
4Research Division, Chugai Pharmaceutical Co. Ltd, 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan
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Satoshi Wakabayashi
5Pharmacokinetics and Metabolism, Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-cho, Saitama-shi, Saitama 330-8530, Japan
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Tomoya Miyoshi
6Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan
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Eriko Higashi
6Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan
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Seiichi Ishida
7Division of Pharmacology, National Institute of Health Science, 3-25-26 Tonomati, Kawasaki 210-9501, Japan
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Nobuaki Shiraki
1School of Life Science and Technology, Tokyo Institute of Technology, 4259-B-25 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan
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  • For correspondence: skume@bio.titech.ac.jp shiraki@bio.titech.ac.jp
Shoen Kume
1School of Life Science and Technology, Tokyo Institute of Technology, 4259-B-25 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan
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  • For correspondence: skume@bio.titech.ac.jp shiraki@bio.titech.ac.jp
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Article Information

vol. 8 no. 7, bio042192

DOI 
https://doi.org/10.1242/bio.042192
PubMed 
31182631

Published By 
The Company of Biologists Ltd
Online ISSN 
2046-6390
History 
  • Received February 1, 2019
  • Accepted May 19, 2019
  • Published online July 2, 2019.
Posted online 
June 10, 2019
Copyright & Usage 
© 2019. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Article Versions

  • Previous version (June 10, 2019 - 01:46).
  • You are viewing the most recent version of this article.

Author Information

  1. Shun Nakai1,
  2. Ima Shibata1,
  3. Takahiro Shitamichi1,
  4. Hiroyuki Yamaguchi2,
  5. Nobuyuki Takagi3,
  6. Tomoaki Inoue4,
  7. Toshito Nakagawa4,
  8. Jumpei Kiyokawa4,
  9. Satoshi Wakabayashi5,
  10. Tomoya Miyoshi6,
  11. Eriko Higashi6,
  12. Seiichi Ishida7,
  13. Nobuaki Shiraki1,* and
  14. Shoen Kume1,*
  1. 1School of Life Science and Technology, Tokyo Institute of Technology, 4259-B-25 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan
  2. 2Isehara Research Laboratory, Technology and Development Division, Kanto Chemical Co., Inc., 21 Suzukawa, Isehara, Kanagawa 259-1146, Japan
  3. 3Technology and Development Division, Kanto Chemical Co., Inc., 2-1, Nihonbashi Muromachi 2-chome, Chuo-ku, Tokyo 103-0022, Japan
  4. 4Research Division, Chugai Pharmaceutical Co. Ltd, 1-135 Komakado, Gotemba, Shizuoka 412-8513, Japan
  5. 5Pharmacokinetics and Metabolism, Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-cho, Saitama-shi, Saitama 330-8530, Japan
  6. 6Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc., 6-10-1 Tebiro, Kamakura, Kanagawa 248-8555, Japan
  7. 7Division of Pharmacology, National Institute of Health Science, 3-25-26 Tonomati, Kawasaki 210-9501, Japan
  1. ↵*Author for correspondence (skume{at}bio.titech.ac.jp; shiraki{at}bio.titech.ac.jp)
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Keywords

  • Hepatocytic differentiation
  • In vitro differentiation
  • Induced pluripotent stem cells

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Research Article
Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells
Shun Nakai, Ima Shibata, Takahiro Shitamichi, Hiroyuki Yamaguchi, Nobuyuki Takagi, Tomoaki Inoue, Toshito Nakagawa, Jumpei Kiyokawa, Satoshi Wakabayashi, Tomoya Miyoshi, Eriko Higashi, Seiichi Ishida, Nobuaki Shiraki, Shoen Kume
Biology Open 2019 8: bio042192 doi: 10.1242/bio.042192 Published 2 July 2019
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Research Article
Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells
Shun Nakai, Ima Shibata, Takahiro Shitamichi, Hiroyuki Yamaguchi, Nobuyuki Takagi, Tomoaki Inoue, Toshito Nakagawa, Jumpei Kiyokawa, Satoshi Wakabayashi, Tomoya Miyoshi, Eriko Higashi, Seiichi Ishida, Nobuaki Shiraki, Shoen Kume
Biology Open 2019 8: bio042192 doi: 10.1242/bio.042192 Published 2 July 2019

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