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  You have access

  Open access

August, 2019; 8 (8)

RESEARCH ARTICLES

  • Open Access
    Multi-modal and multiscale imaging approaches reveal novel cardiovascular pathophysiology in Drosophila melanogaster
    Constance G. Weismann, Anna Blice-Baum, Tangji Tong, Joyce Li, Brendan K. Huang, Stephan M. Jonas, Anthony Cammarato, Michael A. Choma
    Biology Open 2019 8: bio044339 doi: 10.1242/bio.044339 Published 27 August 2019

    Summary: Mutant troponin I increases aortic and myocardial stiffness and engenders histologic abnormalities in fruit flies.

  • Open Access
    Accuracy of fruit-fly eclosion rhythms evolves by strengthening circadian gating rather than developmental fine-tuning
    Vishwanath Varma, Shambhavi Krishna, Manishi Srivastava, Vijay Kumar Sharma, Vasu Sheeba
    Biology Open 2019 8: bio042176 doi: 10.1242/bio.042176 Published 27 August 2019

    Summary: Fruit fly populations that have evolved greater accuracy of eclosion rhythms show enhanced gating of their eclosion by circadian clocks but not reduced variation in clock-independent developmental processes.

  • Open Access
    Unique trophoblast chromatin environment mediated by the PcG protein SFMBT2
    Priscilla Tang, Kamelia Miri, Susannah Varmuza
    Biology Open 2019 8: bio043638 doi: 10.1242/bio.043638 Published 23 August 2019

    Summary: The PcG protein SFMBT2, essential for placenta development, is distributed mainly to repetitive elements in trophoblast stem cells, arguing for an architectural role in stem cell maintenance.

  • Open Access
    A Plasmodium berghei putative serine-threonine kinase 2 (PBANKA_0311400) is required for late liver stage development and timely initiation of blood stage infection
    Ravi Jillapalli, Sunil Kumar Narwal, Surendra Kumar Kolli, Babu S. Mastan, Rameswara Reddy Segireddy, Sandeep Dey, Pratik Narain Srivastava, Satish Mishra, Kota Arun Kumar
    Biology Open 2019 8: bio042028 doi: 10.1242/bio.042028 Published 23 August 2019

    Summary: Requirement of a putative serine threonine kinase 2 (PBANKA_0311400) for Plasmodium berghei liver stage development.

  • Open Access
    EGFP insertional mutagenesis reveals multiple FXR2P fibrillar states with differing ribosome association in neurons
    Emily E. Stackpole, Michael R. Akins, Maria Ivshina, Anastasia C. Murthy, Nicolas L. Fawzi, Justin R. Fallon
    Biology Open 2019 8: bio046383 doi: 10.1242/bio.046383 Published 21 August 2019

    Summary: A mutagenesis study reveals that the higher-order structural states of the RBP FXR2P in neurons can be regulated by manipulation of the LC and RNA-binding domains.

  • Open Access
    Role of Dach1 revealed using a novel inner ear-specific Dach1-knockdown mouse model
    Toru Miwa, Ryosei Minoda, Yoshihide Ishikawa, Tomohito Kajii, Yorihisa Orita, Takahiro Ohyama
    Biology Open 2019 8: bio043612 doi: 10.1242/bio.043612 Published 20 August 2019

    Summary: Inner ear-specific downregulation of Dach1 reveals that the epithelial–mesenchymal transition is crucial for the generation of the stria vascularis.

  • Open Access
    Mechanical stress-induced cell death in breast cancer cells
    Satomi Takao, Minoru Taya, Cerwyn Chiew
    Biology Open 2019 8: bio043133 doi: 10.1242/bio.043133 Published 16 August 2019

    Summary: Dynamic mechanical compressive stress loading applied to two different breast cancer cell lines results in mechanical stress-induced cell damage (MSICD) composed of apoptosis and necrosis.

  • Open Access
    Exposure to a 50 Hz magnetic field at 100 µT exerts no DNA damage in cardiomyocytes
    Yong Wang, Xingfa Liu, Yemao Zhang, Baoquan Wan, Jiangong Zhang, Wei He, Dong Hu, Yong Yang, Jinsheng Lai, Mengying He, Chen Chen
    Biology Open 2019 8: bio041293 doi: 10.1242/bio.041293 Published 15 August 2019

    Summary: The current study shows that neither continuous nor intermittent exposure to a 50 Hz magnetic field at 100 µT induces DNA damage in cardiomyocytes.

  • Open Access
    Inhalation of marijuana affects Drosophila heart function
    Ivana M. Gómez, Maia A. Rodríguez, Manuela Santalla, George Kassis, Jorge E. Colman Lerner, J. Oswaldo Aranda, Daniela Sedán, Dario Andrinolo, Carlos A. Valverde, Paola Ferrero
    Biology Open 2019 8: bio044081 doi: 10.1242/bio.044081 Published 15 August 2019

    Summary: Marijuana induces early arrhythmogenesis and increases contractility in Drosophila. Our approach using this animal model allows us to carry out screenings to explore the impact of cannabinoids.

  • Open Access
    The ventral epithelium of Trichoplax adhaerens deploys in distinct patterns cells that secrete digestive enzymes, mucus or diverse neuropeptides
    Tatiana D. Mayorova, Katherine Hammar, Christine A. Winters, Thomas S. Reese, Carolyn L. Smith
    Biology Open 2019 8: bio045674 doi: 10.1242/bio.045674 Published 9 August 2019

    Summary: The external digestive epithelium of the primitive animal Trichoplax adhaerens includes secretory cell types and secretory products much like those in the internal digestive systems of other animals.

  • Open Access
    Independent evolution for sex determination and differentiation in the DMRT family in animals
    Shuuji Mawaribuchi, Yuzuru Ito, Michihiko Ito
    Biology Open 2019 8: bio041962 doi: 10.1242/bio.041962 Published 9 August 2019

    Summary: Three DMRT family genes, vertebrate dmrt1, arthropod dsx and nematode mab-3, involved in sex determination and primary sex differentiation have no orthologous relationships, indicating independent evolution in bilaterian animals.

  • Open Access
    HDAC3 and HDAC8 are required for cilia assembly and elongation
    Seon-ah Park, Hyunjeong Yoo, Jae Hong Seol, Kunsoo Rhee
    Biology Open 2019 8: bio043828 doi: 10.1242/bio.043828 Published 9 August 2019

    Summary: We identified that HDAC3 and HDAC8 are required for the assembly and elongation of the primary cilia.

  • Open Access
    YFR016c/Aip5 is part of an actin nucleation complex in yeast
    Oliver Glomb, Lara Bareis, Nils Johnsson
    Biology Open 2019 8: bio044024 doi: 10.1242/bio.044024 Published 9 August 2019

    Summary: YFR016c/Aip5 binds to the polarisome components Bud6 and Spa2 and supports the polarisome in the formation of actin cables in yeast cells.

  • Open Access
    Discoidin domain receptor 1 deficiency in vascular smooth muscle cells leads to mislocalisation of N-cadherin contacts
    Songyi Xu, Sudarshan Bala, Michelle P. Bendeck
    Biology Open 2019 8: bio041913 doi: 10.1242/bio.041913 Published 9 August 2019

    Summary: Here we show for the first time that discoidin domain receptor 1 associates with and stabilizes N-cadherin cell–cell contacts in vascular smooth muscle cells.

  • Open Access
    The Col4a2em1(IMPC)Wtsi mouse line: lessons from the Deciphering the Mechanisms of Developmental Disorders program
    Lukas F. Reissig, Anna Nele Herdina, Julia Rose, Barbara Maurer-Gesek, Jenna L. Lane, Fabrice Prin, Robert Wilson, Emily Hardman, Antonella Galli, Catherine Tudor, Elizabeth Tuck, Cecilia Icoresi-Mazzeo, Jacqueline K. White, Ed Ryder, Diane Gleeson, David J. Adams, Stefan H. Geyer, Timothy J. Mohun, Wolfgang J. Weninger
    Biology Open 2019 8: bio042895 doi: 10.1242/bio.042895 Published 1 August 2019

    Summary: We define the spectrum of phenotypic abnormalities linked with Col4a2 disruption and demonstrate the opportunities the Deciphering the Mechanisms of Developmental Disorders (DMDD) program offers for exploring rare human diseases.

  • Open Access
    MicroRNA-138 negatively regulates the hypoxia-inducible factor 1α to suppress melanoma growth and metastasis
    Haijiang Qiu, Fangchao Chen, Minjun Chen
    Biology Open 2019 8: bio042937 doi: 10.1242/bio.042937 Published 1 August 2019

    Summary: Our study demonstrates the role and clinical relevance of miRNA-138 and HIF1α in melanoma cell growth and metastasis, providing a novel therapeutic target for suppression of melanoma growth and metastasis.

  • Open Access
    Reduced mTORC1-signalling in retinal progenitor cells leads to visual pathway dysfunction
    Iwan Jones, Anna-Carin Hägglund, Leif Carlsson
    Biology Open 2019 8: bio044370 doi: 10.1242/bio.044370 Published 1 August 2019

    Summary: Conditional deletion of Rptor in retinal progenitor cells demonstrates that mTORC1-signalling is critical for visual pathway development and function.

  • Open Access
    Comparing 3D ultrastructure of presynaptic and postsynaptic mitochondria
    Thomas Delgado, Ronald S. Petralia, David W. Freeman, Miloslav Sedlacek, Ya-Xian Wang, Stephan D. Brenowitz, Shu-Hsien Sheu, Jeffrey W. Gu, Dimitrios Kapogiannis, Mark P. Mattson, Pamela J. Yao
    Biology Open 2019 8: bio044834 doi: 10.1242/bio.044834 Published 1 August 2019

    Summary: Our 3D ultrastructural analysis of multiple brain regions shows distinctively different sizes and shapes of mitochondria in the presynaptic terminal and postsynaptic dendrite.

METHODS AND TECHNIQUES

  • Open Access
    Three-dimensional analysis of single molecule FISH in human colon organoids
    Manja Omerzu, Nicola Fenderico, Buys de Barbanson, Joep Sprangers, Jeroen de Ridder, Madelon M. Maurice
    Biology Open 2019 8: bio042812 doi: 10.1242/bio.042812 Published 9 August 2019

    Summary: We present a sensitive single-molecule (sm)FISH application for the identification of individual mRNA transcripts and their spatial distribution in 3D in whole human colon organoids.

FIRST PERSON

  • Open Access
    First person – Vishwanath Varma
    Biology Open 2019 8: bio047027 doi: 10.1242/bio.047027 Published 27 August 2019
  • Open Access
    First person – Toru Miwa
    Biology Open 2019 8: bio046821 doi: 10.1242/bio.046821 Published 20 August 2019
  • Open Access
    First person – Ivana María Gómez and Maia Abigail Rodríguez
    Biology Open 2019 8: bio046409 doi: 10.1242/bio.046409 Published 15 August 2019
  • Open Access
    First person – Yong Wang
    Biology Open 2019 8: bio046714 doi: 10.1242/bio.046714 Published 15 August 2019
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  • Open Access

    Notch signaling governs the expression of glypican Dally to define the stem cell niche

    Songhua Zhao, Chan Wu, Zhiyang Gao, Xin Li, Guo Zheng, Zhaohui Wang
    PDF
  • Open Access

    Visualisation of ribosomes in Drosophila axons using Ribo-BiFC

    Anand K. Singh, Akilu Abdullahi, Matthias Soller, Alexandre David, Saverio Brogna
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  • Open Access

    Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease

    Juan Garrido-Maraver, Samantha H. Y. Loh, L. Miguel Martins
    PDF
  • Open Access

    Larval mannitol diets increase mortality, prolong development, and decrease adult body sizes in fruit flies (Drosophila melanogaster)

    Meghan Barrett, Katherine Fiocca, Edward A. Waddell, Cheyenne McNair, Sean O'Donnell, Daniel R. Marenda
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  • Open Access

    The interconnection between cytokeratin and cell membrane-bound β-catenin in Sertoli cells derived from juvenile Xenopus tropicalis testes

    Thi Minh Xuan Nguyen, Marketa Vegrichtova, Tereza Tlapakova, Magdalena Krulova, Vladimir Krylov
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