This issue is currently being compiled. Articles in their final version of record are published here as soon as they are ready. The most recent articles appear at the top of the relevant section.
RESEARCH ARTICLES
- CT-2A neurospheres-derived high-grade glioma in mice: a new model to address tumor stem cells and immunosuppression
Summary: The NS/CT-2A tumor model represents a valuable research platform for the study of innovative treatments aimed at eliminating GSCs and reversing the tumor-induced immunosuppression in HGGs.
- Overexpression of an alfalfa glutathione S-transferase gene improved the saline-alkali tolerance of transgenic tobacco
Summary: The glutathione S-transferase gene of Medicago sativa can effectively alleviate osmotic and oxidative damage induced by saline-alkali stress in transgenic tobacco.
- RAB21 interacts with TMED10 and modulates its localization and abundance
Summary: A small early endosomal RAB GTPase is found to interact with p24 family members, with potential impacts on p24 functions.
- Fgf8a mutation affects craniofacial development and skeletal gene expression in zebrafish larvae
Summary: A function-blocking mutation in fgf8a causes craniofacial malformations in zebrafish larvae due to impaired cranial neural crest cell migration and survival.
- Knockdown of HE4 suppresses aggressive cell growth and malignant progression of ovarian cancer by inhibiting the JAK/STAT3 pathway
Summary: Our findings reported that HE4 knockdown suppresses aggressive cell growth and malignant progression of ovarian cancer by inhibiting the JAK/STAT3 pathway, which could provide a valuable insight into developing novel HE4-targeted therapies.
- The auxiliary ESCRT complexes provide robustness to cold in poikilothermic organisms
Summary: The analysis of Chmp5 and Ist1, which belong to the two ESCRT auxiliary sub-complexes in Drosophila, suggests that these ESCRT proteins provide robustness against cold in diverse poikilothermic organisms.
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Cover article – Three-dimensional analysis of single molecule FISH in human colon organoids
Madelon Maurice and her colleagues present a sensitive single-molecule FISH application for the identification of individual mRNA transcripts and their spatial distribution in 3D in whole human colon organoids.
Featured article – The ventral epithelium of Trichoplax adhaerens deploys in distinct patterns cells that secrete digestive enzymes, mucus or diverse neuropeptides
Carolyn Smith, Tatiana Mayorova and their co-workers show that the external digestive epithelium of the primitive animal Trichoplax adhaerens includes secretory cell types and secretory products much like those in the internal digestive systems of other animals.
Have you seen our interviews with the early-career first authors of our papers? Recently, we caught up with first authors Vishwanath Varma, Toru Miwa, Ivana María Gómez and Maia Abigail Rodríguez, and Yong Wang.
Biology Open has strong credentials and publishing with us is easy and fast. BiO aims to provide rapid publication for scientifically sound observations and valid conclusions in developmental, cell, experimental and translational biology. Submit your paper here – you’ll be in good company!
Recent developmental biology highlights in BiO – Anna Nele Herdina and her colleagues define the spectrum of phenotypic abnormalities linked with Col4a2 disruption and demonstrate the opportunities the Deciphering the Mechanisms of Developmental Disorders (DMDD) program offers for exploring rare human diseases.
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preLights - Isolation of an archaeon at the prokaryote-eukaryote interface
Gautam Dey highlights a preprint from Hiroyuki Imachi, Masaru Nobu and colleagues, who are the first to charactarise a species of the “Asgard archaea”, an archaeal lineage that may have been the precursor of eukaryotes!