RESEARCH ARTICLES
- The torso-like gene functions to maintain the structure of the vitelline membrane in Nasonia vitripennis, implying its co-option into Drosophila axis formation
Summary: In the parasitic wasp Nasonia, Tsl, a key component of the process that defines the termini of the embryo of Drosophila, has a function in the structure of the vitelline membrane.
- Apolipoprotein L9 interacts with LC3/GABARAP and is a microtubule-associated protein with a widespread subcellular distribution
Summary: This article is about how Apolipoprotein L9, a lipid-binding protein, has versatile properties and influences a variety of processes taking place inside an animal cell.
- The circular RNA PVT1/miR-203/HOXD3 pathway promotes the progression of human hepatocellular carcinoma
Summary: Our research is the first to characterize the role of circPVT1 in the initiation and progression of HCC. CircPVT1 could be applied as a potential biomarker for the early screening of HCC.
- Failure to identify modifiers of NEBULIN-related nemaline myopathy in two pre-clinical models of the disease
Summary: NEBULIN-related nemaline myopathy currently has no treatment. We attempted to uncover new avenues for therapy by performing modifier screens, which unfortunately failed to identify modifiers that improved disease relevant phenotypes.
- Characteristics and function of a novel cystatin gene in the pine wood nematode Bursaphelenchus xylophilus
Summary: Bx-cpi-1, a variant of a type II cystatin gene, was abundantly expressed in the reproductive organs of Bursaphelenchus xylophilus, and involved in the development and pathogenicity of B. xylophilus.
- Experimental model of peri-prosthetic infection of the knee caused by Staphylococcus aureus using biomaterials representative of modern TKA
Summary: The availability of a reproducible animal model using current and clinically representative materials will facilitate translational research for innovative therapeutic approaches for prosthetic joint infections caused by Staphylococcus aureus.
- Feedback loops in the Plk4–STIL–HsSAS6 network coordinate site selection for procentriole formation
Summary: The findings in this study illustrate how the dynamic behavior and interactions between critical duplication factors coordinate the centriole-duplication process in human cells, based on live-cell imaging of endogenously tagged proteins and mathematical modeling.
- Requirement of IFT-B–BBSome complex interaction in export of GPR161 from cilia
Summary: We here determine an interface between the IFT-B complex and the BBSome involving IFT38 and BBS1+BBS2+BBS9, and show that the interaction is crucial for GPR161 export from cilia.
- CT-2A neurospheres-derived high-grade glioma in mice: a new model to address tumor stem cells and immunosuppression
Summary: The NS/CT-2A tumor model represents a valuable research platform for the study of innovative treatments aimed at eliminating GSCs and reversing the tumor-induced immunosuppression in HGGs.
- Overexpression of an alfalfa glutathione S-transferase gene improved the saline-alkali tolerance of transgenic tobacco
Summary: The glutathione S-transferase gene of Medicago sativa can effectively alleviate osmotic and oxidative damage induced by saline-alkali stress in transgenic tobacco.
- RAB21 interacts with TMED10 and modulates its localization and abundance
Summary: A small early endosomal RAB GTPase is found to interact with p24 family members, with potential impacts on p24 functions.
- Fgf8a mutation affects craniofacial development and skeletal gene expression in zebrafish larvae
Summary: A function-blocking mutation in fgf8a causes craniofacial malformations in zebrafish larvae due to impaired cranial neural crest cell migration and survival.
- Knockdown of HE4 suppresses aggressive cell growth and malignant progression of ovarian cancer by inhibiting the JAK/STAT3 pathway
Summary: Our findings reported that HE4 knockdown suppresses aggressive cell growth and malignant progression of ovarian cancer by inhibiting the JAK/STAT3 pathway, which could provide a valuable insight into developing novel HE4-targeted therapies.
- The auxiliary ESCRT complexes provide robustness to cold in poikilothermic organisms
Summary: The analysis of Chmp5 and Ist1, which belong to the two ESCRT auxiliary sub-complexes in Drosophila, suggests that these ESCRT proteins provide robustness against cold in diverse poikilothermic organisms.