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  Open access

September, 2019; 8 (9)

RESEARCH ARTICLES

  • Open Access
    The torso-like gene functions to maintain the structure of the vitelline membrane in Nasonia vitripennis, implying its co-option into Drosophila axis formation
    Shannon E. Taylor, Jack Tuffery, Daniel Bakopoulos, Sharon Lequeux, Coral G. Warr, Travis K. Johnson, Peter K. Dearden
    Biology Open 2019 8: bio046284 doi: 10.1242/bio.046284 Published 25 September 2019

    Summary: In the parasitic wasp Nasonia, Tsl, a key component of the process that defines the termini of the embryo of Drosophila, has a function in the structure of the vitelline membrane.

  • Open Access
    Apolipoprotein L9 interacts with LC3/GABARAP and is a microtubule-associated protein with a widespread subcellular distribution
    Arvind A. Thekkinghat, Kamlesh K. Yadav, Pundi N. Rangarajan
    Biology Open 2019 8: bio045930 doi: 10.1242/bio.045930 Published 25 September 2019

    Summary: This article is about how Apolipoprotein L9, a lipid-binding protein, has versatile properties and influences a variety of processes taking place inside an animal cell.

  • Open Access
    The circular RNA PVT1/miR-203/HOXD3 pathway promotes the progression of human hepatocellular carcinoma
    Yiqing Zhu, Yan Liu, Bang Xiao, Hui Cai, Meng Liu, Liye Ma, Huirong Yin, Fang Wang
    Biology Open 2019 8: bio043687 doi: 10.1242/bio.043687 Published 25 September 2019

    Summary: Our research is the first to characterize the role of circPVT1 in the initiation and progression of HCC. CircPVT1 could be applied as a potential biomarker for the early screening of HCC.

  • Open Access
    Failure to identify modifiers of NEBULIN-related nemaline myopathy in two pre-clinical models of the disease
    Boyang Qiu, Julie Ruston, Henk Granzier, Monica J. Justice, James J. Dowling
    Biology Open 2019 8: bio044867 doi: 10.1242/bio.044867 Published 18 September 2019

    Summary: NEBULIN-related nemaline myopathy currently has no treatment. We attempted to uncover new avenues for therapy by performing modifier screens, which unfortunately failed to identify modifiers that improved disease relevant phenotypes.

  • Open Access
    Characteristics and function of a novel cystatin gene in the pine wood nematode Bursaphelenchus xylophilus
    Qi Xue, Xiao-Qin Wu
    Biology Open 2019 8: bio042655 doi: 10.1242/bio.042655 Published 18 September 2019

    Summary: Bx-cpi-1, a variant of a type II cystatin gene, was abundantly expressed in the reproductive organs of Bursaphelenchus xylophilus, and involved in the development and pathogenicity of B. xylophilus.

  • Open Access
    Experimental model of peri-prosthetic infection of the knee caused by Staphylococcus aureus using biomaterials representative of modern TKA
    Jodie L. Morris, Hayley L. Letson, Andrea Grant, Matthew Wilkinson, Kaushik Hazratwala, Peter McEwen
    Biology Open 2019 8: bio045203 doi: 10.1242/bio.045203 Published 18 September 2019

    Summary: The availability of a reproducible animal model using current and clinically representative materials will facilitate translational research for innovative therapeutic approaches for prosthetic joint infections caused by Staphylococcus aureus.

  • Open Access
    Feedback loops in the Plk4–STIL–HsSAS6 network coordinate site selection for procentriole formation
    Daisuke Takao, Koki Watanabe, Kanako Kuroki, Daiju Kitagawa
    Biology Open 2019 8: bio047175 doi: 10.1242/bio.047175 Published 18 September 2019

    Summary: The findings in this study illustrate how the dynamic behavior and interactions between critical duplication factors coordinate the centriole-duplication process in human cells, based on live-cell imaging of endogenously tagged proteins and mathematical modeling.

  • Open Access
    Requirement of IFT-B–BBSome complex interaction in export of GPR161 from cilia
    Shohei Nozaki, Roiner Francisco Castro Araya, Yohei Katoh, Kazuhisa Nakayama
    Biology Open 2019 8: bio043786 doi: 10.1242/bio.043786 Published 17 September 2019

    Summary: We here determine an interface between the IFT-B complex and the BBSome involving IFT38 and BBS1+BBS2+BBS9, and show that the interaction is crucial for GPR161 export from cilia.

  • Open Access
    CT-2A neurospheres-derived high-grade glioma in mice: a new model to address tumor stem cells and immunosuppression
    Matteo Riva, Roxanne Wouters, Akila Weerasekera, Sarah Belderbos, David Nittner, Dietmar R. Thal, Thaïs Baert, Roberto Giovannoni, Willy Gsell, Uwe Himmelreich, Marc Van Ranst, An Coosemans
    Biology Open 2019 8: bio044552 doi: 10.1242/bio.044552 Published 12 September 2019

    Summary: The NS/CT-2A tumor model represents a valuable research platform for the study of innovative treatments aimed at eliminating GSCs and reversing the tumor-induced immunosuppression in HGGs.

  • Open Access
    Overexpression of an alfalfa glutathione S-transferase gene improved the saline-alkali tolerance of transgenic tobacco
    Binghao Du, Weidi Zhao, Yimin An, Yakun Li, Xue Zhang, Lili Song, Changhong Guo
    Biology Open 2019 8: bio043505 doi: 10.1242/bio.043505 Published 9 September 2019

    Summary: The glutathione S-transferase gene of Medicago sativa can effectively alleviate osmotic and oxidative damage induced by saline-alkali stress in transgenic tobacco.

  • Open Access
    RAB21 interacts with TMED10 and modulates its localization and abundance
    Tomas Del Olmo, Camille Lacarrière-Keïta, Caroline Normandin, Dominique Jean, François-Michel Boisvert, Steve Jean
    Biology Open 2019 8: bio045336 doi: 10.1242/bio.045336 Published 9 September 2019

    Summary: A small early endosomal RAB GTPase is found to interact with p24 family members, with potential impacts on p24 functions.

  • Open Access
    Fgf8a mutation affects craniofacial development and skeletal gene expression in zebrafish larvae
    I. G. E. Gebuijs, S. T. Raterman, J. R. Metz, L. Swanenberg, J. Zethof, R. Van den Bos, C. E. L. Carels, F. A. D. T. G. Wagener, J. W. Von den Hoff
    Biology Open 2019 8: bio039834 doi: 10.1242/bio.039834 Published 9 September 2019

    Summary: A function-blocking mutation in fgf8a causes craniofacial malformations in zebrafish larvae due to impaired cranial neural crest cell migration and survival.

  • Open Access
    Knockdown of HE4 suppresses aggressive cell growth and malignant progression of ovarian cancer by inhibiting the JAK/STAT3 pathway
    Aihong Wang, Canhui Jin, Xiaoyu Tian, Ying Wang, Hongyu Li
    Biology Open 2019 8: bio043570 doi: 10.1242/bio.043570 Published 2 September 2019

    Summary: Our findings reported that HE4 knockdown suppresses aggressive cell growth and malignant progression of ovarian cancer by inhibiting the JAK/STAT3 pathway, which could provide a valuable insight into developing novel HE4-targeted therapies.

  • Open Access
    The auxiliary ESCRT complexes provide robustness to cold in poikilothermic organisms
    Miriam Bäumers, Sven Klose, Christian Brüser, Carl Haag, Sebastian Hänsch, Hendrik Pannen, Stefanie Weidtkamp-Peters, Michael Feldbrügge, Thomas Klein
    Biology Open 2019 8: bio043422 doi: 10.1242/bio.043422 Published 2 September 2019

    Summary: The analysis of Chmp5 and Ist1, which belong to the two ESCRT auxiliary sub-complexes in Drosophila, suggests that these ESCRT proteins provide robustness against cold in diverse poikilothermic organisms.

FIRST PERSON

  • Open Access
    First person – Arvind Thekkinghat
    Biology Open 2019 8: bio047886 doi: 10.1242/bio.047886 Published 25 September 2019
  • Open Access
    First person – Shannon Taylor
    Biology Open 2019 8: bio047860 doi: 10.1242/bio.047860 Published 25 September 2019
  • Open Access
    First person – Daisuke Takao
    Biology Open 2019 8: bio047670 doi: 10.1242/bio.047670 Published 18 September 2019
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  • Open Access

    Notch signaling governs the expression of glypican Dally to define the stem cell niche

    Songhua Zhao, Chan Wu, Zhiyang Gao, Xin Li, Guo Zheng, Zhaohui Wang
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  • Open Access

    Visualisation of ribosomes in Drosophila axons using Ribo-BiFC

    Anand K. Singh, Akilu Abdullahi, Matthias Soller, Alexandre David, Saverio Brogna
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  • Open Access

    Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease

    Juan Garrido-Maraver, Samantha H. Y. Loh, L. Miguel Martins
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  • Open Access

    Larval mannitol diets increase mortality, prolong development, and decrease adult body sizes in fruit flies (Drosophila melanogaster)

    Meghan Barrett, Katherine Fiocca, Edward A. Waddell, Cheyenne McNair, Sean O'Donnell, Daniel R. Marenda
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  • Open Access

    The interconnection between cytokeratin and cell membrane-bound β-catenin in Sertoli cells derived from juvenile Xenopus tropicalis testes

    Thi Minh Xuan Nguyen, Marketa Vegrichtova, Tereza Tlapakova, Magdalena Krulova, Vladimir Krylov
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