RESEARCH ARTICLES
- The torso-like gene functions to maintain the structure of the vitelline membrane in Nasonia vitripennis, implying its co-option into Drosophila axis formation
Summary: In the parasitic wasp Nasonia, Tsl, a key component of the process that defines the termini of the embryo of Drosophila, has a function in the structure of the vitelline membrane.
- Apolipoprotein L9 interacts with LC3/GABARAP and is a microtubule-associated protein with a widespread subcellular distribution
Summary: This article is about how Apolipoprotein L9, a lipid-binding protein, has versatile properties and influences a variety of processes taking place inside an animal cell.
- The circular RNA PVT1/miR-203/HOXD3 pathway promotes the progression of human hepatocellular carcinoma
Summary: Our research is the first to characterize the role of circPVT1 in the initiation and progression of HCC. CircPVT1 could be applied as a potential biomarker for the early screening of HCC.
- Failure to identify modifiers of NEBULIN-related nemaline myopathy in two pre-clinical models of the disease
Summary: NEBULIN-related nemaline myopathy currently has no treatment. We attempted to uncover new avenues for therapy by performing modifier screens, which unfortunately failed to identify modifiers that improved disease relevant phenotypes.
- Characteristics and function of a novel cystatin gene in the pine wood nematode Bursaphelenchus xylophilus
Summary: Bx-cpi-1, a variant of a type II cystatin gene, was abundantly expressed in the reproductive organs of Bursaphelenchus xylophilus, and involved in the development and pathogenicity of B. xylophilus.
- Experimental model of peri-prosthetic infection of the knee caused by Staphylococcus aureus using biomaterials representative of modern TKA
Summary: The availability of a reproducible animal model using current and clinically representative materials will facilitate translational research for innovative therapeutic approaches for prosthetic joint infections caused by Staphylococcus aureus.
- Feedback loops in the Plk4–STIL–HsSAS6 network coordinate site selection for procentriole formation
Summary: The findings in this study illustrate how the dynamic behavior and interactions between critical duplication factors coordinate the centriole-duplication process in human cells, based on live-cell imaging of endogenously tagged proteins and mathematical modeling.
- Requirement of IFT-B–BBSome complex interaction in export of GPR161 from cilia
Summary: We here determine an interface between the IFT-B complex and the BBSome involving IFT38 and BBS1+BBS2+BBS9, and show that the interaction is crucial for GPR161 export from cilia.
- CT-2A neurospheres-derived high-grade glioma in mice: a new model to address tumor stem cells and immunosuppression
Summary: The NS/CT-2A tumor model represents a valuable research platform for the study of innovative treatments aimed at eliminating GSCs and reversing the tumor-induced immunosuppression in HGGs.
- Overexpression of an alfalfa glutathione S-transferase gene improved the saline-alkali tolerance of transgenic tobacco
Summary: The glutathione S-transferase gene of Medicago sativa can effectively alleviate osmotic and oxidative damage induced by saline-alkali stress in transgenic tobacco.
- RAB21 interacts with TMED10 and modulates its localization and abundance
Summary: A small early endosomal RAB GTPase is found to interact with p24 family members, with potential impacts on p24 functions.
- Fgf8a mutation affects craniofacial development and skeletal gene expression in zebrafish larvae
Summary: A function-blocking mutation in fgf8a causes craniofacial malformations in zebrafish larvae due to impaired cranial neural crest cell migration and survival.
- Knockdown of HE4 suppresses aggressive cell growth and malignant progression of ovarian cancer by inhibiting the JAK/STAT3 pathway
Summary: Our findings reported that HE4 knockdown suppresses aggressive cell growth and malignant progression of ovarian cancer by inhibiting the JAK/STAT3 pathway, which could provide a valuable insight into developing novel HE4-targeted therapies.
- The auxiliary ESCRT complexes provide robustness to cold in poikilothermic organisms
Summary: The analysis of Chmp5 and Ist1, which belong to the two ESCRT auxiliary sub-complexes in Drosophila, suggests that these ESCRT proteins provide robustness against cold in diverse poikilothermic organisms.
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Future Leader Review - Cardiac myosin super relaxation
A new Future Leader Review by Manuel Schmid and Christopher Toepfer discusses the rapidly-expanding field of myosin super relaxation in the context of cardiovascular disease. Read the full Review and their accompanying interview.
Find out more about our Future Leader Reviews – they are an exclusive opportunity for early-career researchers who want to establish themselves in their field.
An interview with Roberta Azzarelli
In an interview, first author Roberta Azzarelli discusses her 3D model of glioblastoma and shares her thoughts on how to improve the professional lives of early-career researchers: formal mentorship programmes, a clearly structured career path and taking part in initiatives such as the Node Network.
News from our sister journals
Development continues to run a successful new webinar series, Development presents…, while Journal of Cell Science has recently welcomed Esperanza Agullo-Pascual as FocalPlane’s new Community Manager. Journal of Experimental Biology’s new special issue highlights the role of comparative biology in tackling climate change and Liz Patton, the new Editor-in-Chief of Disease Models & Mechanisms, sets out her visions and priorities.