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  Open access

November, 2020; 9 (11)

REVIEW

  • Open Access
    Uncharted routes: exploring the relevance of auxin movement via plasmodesmata
    Andrea Paterlini
    Biology Open 2020 9: bio055541 doi: 10.1242/bio.055541 Published 12 November 2020

    Summary: The review discusses the occurrence and biological relevance of auxin transport via plasmodesmata in plants. Physical modes of transport of this hormone, feedbacks on its movement and evolutionary aspects are included.

RESEARCH ARTICLES

  • Open Access
    RhoGAP RGA-8 supports morphogenesis in C. elegans by polarizing epithelia
    Hamidah Raduwan, Shashikala Sasidharan, Luigy Cordova Burgos, Andre G. Wallace, Martha C. Soto
    Biology Open 2020 9: bio056911 doi: 10.1242/bio.056911 Published 26 November 2020

    Summary: RGA-8, a protein with membrane binding and actin regulatory motifs, promotes embryonic morphogenesis by localizing active CDC-42 in developing epithelia, and controlling actin and actin motors during cell movements.

  • Open Access
    Antibiotics in hives and their effects on honey bee physiology and behavioral development
    Yarira Ortiz-Alvarado, David R. Clark, Carlos J. Vega-Melendez, Zomary Flores-Cruz, Maria G. Domingez-Bello, Tugrul Giray
    Biology Open 2020 9: bio053884 doi: 10.1242/bio.053884 Published 16 November 2020

    Summary: Antibiotic treatments in bee colonies cause an increase or decrease in rate of behavioral development and lipid stores of workers, affecting fat body–interaction, likely through effects on microbiota.

  • Open Access
    The role of macrophage migration inhibitory factor in promoting benign prostatic hyperplasia epithelial cell growth by modulating COX-2 and P53 signaling
    Hualin Song, Qi Shen, Shuai Hu, Jie Jin
    Biology Open 2020 9: bio053447 doi: 10.1242/bio.053447 Published 12 November 2020

    Summary: This study found high levels of MIF expression in BPH epithelium. MIF promoted BPH epithelial cell growth and participated in the progression of BPH by regulating COX-2 and P53 signaling

  • Open Access
    Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy
    Jingjing Wu, Youqile Wu, Xuemei Lian
    Biology Open 2020 9: bio053298 doi: 10.1242/bio.053298 Published 12 November 2020

    Summary: GRP78 is highly expressed in the lung cancer tissue, and targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by endoplasmic reticulum stress and autophagy.

  • Open Access
    Influence of maternal diet on offspring survivorship, growth, and reproduction in a sheetweb spider
    Lelei Wen, Zengtao Zhang, Shichang Zhang, Fengxiang Liu, Xiaoguo Jiao, Daiqin Li
    Biology Open 2020 9: bio056846 doi: 10.1242/bio.056846 Published 6 November 2020

    Summary: A single meal immediately before oviposition is sufficient to influence offspring survival, growth, and daughters' reproduction in the sheetweb spider Hylyphantes graminicola.

  • Open Access
    Royal jelly attenuates metabolic defects in a Drosophila mutant with elevated TORC1 activity
    Yang Cheng, Jiadong Cai, Yuanyuan Fu, Congjing Feng, Yue Hao, Youheng Wei
    Biology Open 2020 9: bio054999 doi: 10.1242/bio.054999 Published 6 November 2020

    Summary: Royal jelly (RJ) modulates the reactive oxygen species (ROS) levels and some metabolic defects that associated with hyper TORC1 activity in a Drosophila model.

  • Open Access
    Squids use multiple escape jet patterns throughout ontogeny
    Carly A. York, Ian K. Bartol, Paul S. Krueger, Joseph T. Thompson
    Biology Open 2020 9: bio054585 doi: 10.1242/bio.054585 Published 5 November 2020

    Summary: In this study, we examine the hydrodynamics and kinematics of escape jets in squids throughout ontogeny using 2D/3D velocimetry and high-speed videography.

  • Open Access
    Amyloid-beta peptide and phosphorylated tau in the frontopolar cerebral cortex and in the cerebellum of toothed whales: aging versus hypoxia
    Simona Sacchini, Josué Díaz-Delgado, Antonio Espinosa de los Monteros, Yania Paz, Yara Bernaldo de Quirós, Eva Sierra, Manuel Arbelo, Pedro Herráez, Antonio Fernández
    Biology Open 2020 9: bio054734 doi: 10.1242/bio.054734 Published 5 November 2020

    Summary: Immunohistochemical analysis showed positive immunolabeling for amyloid-beta peptide and phosphorylated tau in the cerebral and cerebellar cortex of toothed whales. These findings could be linked to hypoxic phenomena.

METHODS & TECHNIQUES

  • Open Access
    Fiji plugin for annotating movies with custom arrows
    Stephan Daetwyler, Carl D. Modes, Reto Fiolka
    Biology Open 2020 9: bio056200 doi: 10.1242/bio.056200 Published 1 December 2020

    Summary: We present a user-friendly Fiji plugin to annotate movies with custom arrows, thereby providing biologists with no coding experience an easy tool to highlight dynamic processes in their movies.

  • Open Access
    Assessing methods to quantitatively validate TGFβ-dependent autophagy
    Charles B. Trelford, Gianni M. Di Guglielmo
    Biology Open 2020 9: bio055103 doi: 10.1242/bio.055103 Published 23 November 2020

    Summary: Using various tools including western blotting and immunofluorescence microscopy, it was observed that autophagic flux probes are the most robust tools to quantitatively assess cellular autophagy.

  • Open Access
    Efficient and crucial quality control of HAP1 cell ploidy status
    Tobias B. Beigl, Ine Kjosås, Emilie Seljeseth, Nina Glomnes, Henriette Aksnes
    Biology Open 2020 9: bio057174 doi: 10.1242/bio.057174 Published 12 November 2020

    Summary: Sharing an effective procedure to quality control the near-haploid HAP1 cells for standardized comparison to CRISPR/Cas9 modified versions and demonstrating the need for controlling the spontaneous diploidization of HAP1 cultures.

  • Open Access
    Progressive tracking: a novel procedure to facilitate manual digitization of videos
    Maja Mielke, Peter Aerts, Chris Van Ginneken, Sam Van Wassenbergh, Falk Mielke
    Biology Open 2020 9: bio055962 doi: 10.1242/bio.055962 Published 6 November 2020

    Summary: Progressive tracking is a novel procedure for manual point digitization in markerless videos. It allows for tracking points efficiently without the need to click all individual frames.

  • Open Access
    Inducible modulation of miR-204 levels in a zebrafish melanoma model
    Samanta Sarti, Raffaella De Paolo, Chiara Ippolito, Angela Pucci, Letizia Pitto, Laura Poliseno
    Biology Open 2020 9: bio053785 doi: 10.1242/bio.053785 Published 6 November 2020

    Summary: Sarti et al. describe miniCoopR-I inducible vectors, a refined tool to study the impact exerted by pigmentation on melanogenesis (during embryonic development) versus melanomagenesis (in adult zebrafish).

  • Open Access
    An improved whole life cycle culture protocol for the hydrozoan genetic model Clytia hemisphaerica
    Marion Lechable, Alexandre Jan, Axel Duchene, Julie Uveira, Brandon Weissbourd, Loann Gissat, Sophie Collet, Laurent Gilletta, Sandra Chevalier, Lucas Leclère, Sophie Peron, Carine Barreau, Régis Lasbleiz, Evelyn Houliston, Tsuyoshi Momose
    Biology Open 2020 9: bio051268 doi: 10.1242/bio.051268 Published 5 November 2020

    Summary: We developed a reliable whole life cycle culture method for the hydrozoan jellyfish Clytia hemisphaerica, a model animal for genetics and developmental biology.

FIRST PERSON

  • Open Access
    First person – Tobias Beigl, Ine Kjosås and Emilie Seljeseth
    Biology Open 2020 9: bio057497 doi: 10.1242/bio.057497 Published 2 December 2020
  • Open Access
    First person – Stephan Daetwyler
    Biology Open 2020 9: bio057851 doi: 10.1242/bio.057851 Published 2 December 2020
  • Open Access
    First person – Yarira Ortiz-Alvarado
    Biology Open 2020 9: bio057448 doi: 10.1242/bio.057448 Published 19 November 2020
  • Open Access
    Future Leaders to Watch – Andrea Paterlini
    Biology Open 2020 9: bio057356 doi: 10.1242/bio.057356 Published 16 November 2020
  • Open Access
    First person – Lelei Wen
    Biology Open 2020 9: bio057521 doi: 10.1242/bio.057521 Published 12 November 2020
  • Open Access
    First person – Samanta Sarti
    Biology Open 2020 9: bio057182 doi: 10.1242/bio.057182 Published 6 November 2020
  • Open Access
    First person – Marion Lechable and Alexandre Jan
    Biology Open 2020 9: bio057034 doi: 10.1242/bio.057034 Published 5 November 2020
  • Open Access
    First person – Carly York
    Biology Open 2020 9: bio057109 doi: 10.1242/bio.057109 Published 5 November 2020
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  • Open Access

    Smoking flies: Testing the effect of tobacco cigarettes on heart function of Drosophila melanogaster

    Manuela Santalla, Lucía Pagola, Ivana Gómez, Darío Balcazar, Carlos A. Valverde, Paola Ferrero
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    Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry

    Hantian Qiu, Sayaka Fujisawa, Shohei Nozaki, Yohei Katoh, Kazuhisa Nakayama
    PDF
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    A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference

    Nina Graffmann, Audrey Ncube, Soraia Martins, Aurelian Robert Fiszl, Philipp Reuther, Martina Bohndorf, Wasco Wruck, Mathias Beller, Constantin Czekelius, James Adjaye
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    A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and notch signaling

    Katherine K. Slemmons, Michael D. Deel, Yi-Tzu Lin, Kristianne M. Oristian, Nina Kuprasertkul, Katia C. Genadry, Po-Han Chen, Jen-Tsan Ashley Chi, Corinne M. Linardic
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    Wound-induced polyploidization is dependent on integrin-yki signaling

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